Abstract
Neurohumoral, cardiovascular, and respiratory parameters were evaluated during sustained submaximal exercise (3.2 km/h, 15° elevation) in normal adult mongrel dogs. At the level of activity achieved (fivefold elevation of total body O2 consumption and threefold elevation of cardiac output), significant (P < 0.05) increases in plasma norepinephrine and epinephrine concentration (from 150 ± 23 to 341 ± 35 and from 127 ± 27 to 222 ± 31 pg/ml, respectively) were present, as well as smaller but significant increases in plasma renin activity and plasma aldosterone concentration (from 2.2 ± 0.3 to 3.1 ± 0.6 ng·ml-1·h-1 and from 98 ± 8 to 130 ± 6 pg/ml, respectively). Plasma arginine vasopressin increased variably and insignificantly. The cardiovascular response (heart rate, systemic arterial and pulmonary arterial pressures, left ventricular filling pressure, and calculated total peripheral and pulmonary arteriolar resistance) closely paralleled that of human subjects. Increased hemoglobin concentration was induced by exercise in the dogs. The ventilatory response of the animals was characterized by respiratory alkalosis. These data suggest similarities between canine and human subjects in norepinephrine, plasma renin activity, and plasma aldosterone responses to submaximal exercise. Apparent species differences during submaximal exertion include greater alterations of plasma epinephrine concentration and a respiratory alkalosis in dogs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1040-1045 |
| Number of pages | 6 |
| Journal | Journal of Applied Physiology |
| Volume | 62 |
| Issue number | 3 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Neurohumoral and cardiopulmonary response to sustained submaximal exercise in the dog. / Kirlin, P. C.; Kittleson, Mark D; Johnson, L. E.
In: Journal of Applied Physiology, Vol. 62, No. 3, 1987, p. 1040-1045.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurohumoral and cardiopulmonary response to sustained submaximal exercise in the dog
AU - Kirlin, P. C.
AU - Kittleson, Mark D
AU - Johnson, L. E.
PY - 1987
Y1 - 1987
N2 - Neurohumoral, cardiovascular, and respiratory parameters were evaluated during sustained submaximal exercise (3.2 km/h, 15° elevation) in normal adult mongrel dogs. At the level of activity achieved (fivefold elevation of total body O2 consumption and threefold elevation of cardiac output), significant (P < 0.05) increases in plasma norepinephrine and epinephrine concentration (from 150 ± 23 to 341 ± 35 and from 127 ± 27 to 222 ± 31 pg/ml, respectively) were present, as well as smaller but significant increases in plasma renin activity and plasma aldosterone concentration (from 2.2 ± 0.3 to 3.1 ± 0.6 ng·ml-1·h-1 and from 98 ± 8 to 130 ± 6 pg/ml, respectively). Plasma arginine vasopressin increased variably and insignificantly. The cardiovascular response (heart rate, systemic arterial and pulmonary arterial pressures, left ventricular filling pressure, and calculated total peripheral and pulmonary arteriolar resistance) closely paralleled that of human subjects. Increased hemoglobin concentration was induced by exercise in the dogs. The ventilatory response of the animals was characterized by respiratory alkalosis. These data suggest similarities between canine and human subjects in norepinephrine, plasma renin activity, and plasma aldosterone responses to submaximal exercise. Apparent species differences during submaximal exertion include greater alterations of plasma epinephrine concentration and a respiratory alkalosis in dogs.
AB - Neurohumoral, cardiovascular, and respiratory parameters were evaluated during sustained submaximal exercise (3.2 km/h, 15° elevation) in normal adult mongrel dogs. At the level of activity achieved (fivefold elevation of total body O2 consumption and threefold elevation of cardiac output), significant (P < 0.05) increases in plasma norepinephrine and epinephrine concentration (from 150 ± 23 to 341 ± 35 and from 127 ± 27 to 222 ± 31 pg/ml, respectively) were present, as well as smaller but significant increases in plasma renin activity and plasma aldosterone concentration (from 2.2 ± 0.3 to 3.1 ± 0.6 ng·ml-1·h-1 and from 98 ± 8 to 130 ± 6 pg/ml, respectively). Plasma arginine vasopressin increased variably and insignificantly. The cardiovascular response (heart rate, systemic arterial and pulmonary arterial pressures, left ventricular filling pressure, and calculated total peripheral and pulmonary arteriolar resistance) closely paralleled that of human subjects. Increased hemoglobin concentration was induced by exercise in the dogs. The ventilatory response of the animals was characterized by respiratory alkalosis. These data suggest similarities between canine and human subjects in norepinephrine, plasma renin activity, and plasma aldosterone responses to submaximal exercise. Apparent species differences during submaximal exertion include greater alterations of plasma epinephrine concentration and a respiratory alkalosis in dogs.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023217533&partnerID=8YFLogxK
M3 - Article
C2 - 3553138
AN - SCOPUS:0023217533
VL - 62
SP - 1040
EP - 1045
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 3
ER -