Neurogenic radial glial cells in reptile, rodent and human

From mitosis to migration

Tamily Weissman, Stephen C Noctor, Brian K. Clinton, Lawrence S. Honig, Arnold R. Kriegstein

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Radial glial cells play at least two crucial roles in cortical development: neuronal production in the ventricular zone (VZ) and the subsequent guidance of neuronal migration. There is evidence that radial glia-like cells are present not only during development but in the adult mammalian brain as well. In addition, radial glial cells appear to be neurogenic in the central nervous system of a number of vertebrate species. We demonstrate here that most dividing progenitor cells in the embryonic human VZ express radial glial proteins. Furthermore, we provide evidence that radial glial cells maintain a vimentin-positive radial fiber throughout each stage of cell division. Asymmetric inheritance of this fiber may be an important factor in determining how neuronal progeny will migrate into the developing cortical plate. Although radial glial cells have traditionally been characterized by their role in guiding migration, their role as neuronal progenitors may represent their defining characteristic throughout the vertebrate CNS.

Original languageEnglish (US)
Pages (from-to)550-559
Number of pages10
JournalCerebral Cortex
Volume13
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Ependymoglial Cells
Reptiles
Mitosis
Rodentia
Neuroglia
Vertebrates
Vimentin
Cell Division
Cerebral Cortex
Stem Cells
Central Nervous System
Brain
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neurogenic radial glial cells in reptile, rodent and human : From mitosis to migration. / Weissman, Tamily; Noctor, Stephen C; Clinton, Brian K.; Honig, Lawrence S.; Kriegstein, Arnold R.

In: Cerebral Cortex, Vol. 13, No. 6, 01.06.2003, p. 550-559.

Research output: Contribution to journalArticle

Weissman, Tamily ; Noctor, Stephen C ; Clinton, Brian K. ; Honig, Lawrence S. ; Kriegstein, Arnold R. / Neurogenic radial glial cells in reptile, rodent and human : From mitosis to migration. In: Cerebral Cortex. 2003 ; Vol. 13, No. 6. pp. 550-559.
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