Neurofibrillary tangle-associated alteration of stathmin in Alzheimer's disease

Lee-Way Jin, E. Masliah, D. Iimoto, R. Deteresa, M. Mallory, M. Sundsmo, N. Mori, A. Sobel, T. Saitoh

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Stathmin (p19), a 19-kDa cytosolic phosphoprotein, plays a key role in converting extracellular signals into intracellular biochemical changes. Antibodies and cDNA specific for stathmin were used to study its levels and localization in normal and Alzheimer's disease (AD) brain tissue. The stathmin protein concentration was reduced in AD neocortex as assessed by Western blotting, whereas the concentration of its mRNA detected by both in situ hybridization and slot blot were increased in AD. The alteration of the stathmin protein concentration was negatively correlated with neurofibrillary tangle numbers but not with plaque numbers. Immunoreactivity was evenly localized to the cytoplasm of neurons in control cortical sections, whereas in AD it was preferentially localized to some of the neurofibrillary tangle-bearing neurons. Numbers of stathmin-positive neurons were inversely correlated with tangle numbers but not with plaque numbers in the frontal cortex of AD patients.

Original languageEnglish (US)
Pages (from-to)331-341
Number of pages11
JournalNeurobiology of Aging
Volume17
Issue number3
DOIs
StatePublished - May 1996

Keywords

  • Alzheimer's disease
  • neurodegeneration
  • neurofibrillary tangle
  • signal transduction
  • stathmin

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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    Jin, L-W., Masliah, E., Iimoto, D., Deteresa, R., Mallory, M., Sundsmo, M., Mori, N., Sobel, A., & Saitoh, T. (1996). Neurofibrillary tangle-associated alteration of stathmin in Alzheimer's disease. Neurobiology of Aging, 17(3), 331-341. https://doi.org/10.1016/0197-4580(96)00021-8