Neurofibrillary pathology - Correlation with hippocampal formation atrophy in Alzheimer disease

Matthew Bobinski, Jerzy Wegiel, Henryk M. Wisniewski, Michal Tarnawski, Margaret Bobinski, Barry Reisberg, Mony J. De Leon, Douglas C. Miller

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

The three-dimensionally reconstructed hippocampal formations in three patients with very severe, immobile Alzheimer disease (AD) and three age-matched nondemented individuals were examined for a correlation between atrophy of hippocampal formation subdivisions and neurofibrillary changes, neuronal loss, and extent of amyloid deposition in plaques and vessels. In AD, a similar severe volume loss was observed in both cellular layers and layers composed of fibers. A strong correlation between the decrease in the volume of hippocampal formation subdivisions and the decrease in the total number of neurons suggests a causative role for neuronal loss in hippocampal formation volumetric loss. Strong regional correlations between the relative decreases in the total number of neurons and the relative increases in the total number of neurofibrillary tangles implicates neurofibrillary pathology as a possible etiologic proximate factor in neuronal and volumetric loss in the hippocampal formation of AD patients.

Original languageEnglish (US)
Pages (from-to)909-919
Number of pages11
JournalNeurobiology of Aging
Volume17
Issue number6
DOIs
StatePublished - Nov 1996
Externally publishedYes

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Keywords

  • Alzheimer disease
  • amyloid deposits
  • hippocampal formation
  • morphometry
  • neurofibrillary pathology
  • neuronal loss

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Bobinski, M., Wegiel, J., Wisniewski, H. M., Tarnawski, M., Bobinski, M., Reisberg, B., De Leon, M. J., & Miller, D. C. (1996). Neurofibrillary pathology - Correlation with hippocampal formation atrophy in Alzheimer disease. Neurobiology of Aging, 17(6), 909-919. https://doi.org/10.1016/S0197-4580(96)00160-1