Neurofibrillary accumulation in the zebra (Equus burchelli)

Robert Higgins, M. Vandevelde, E. J. Hoff, J. E. Jagar, L. C. Cork, M. S. Silberman

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord and in the lower brain stem. Ultrastructurally the neuronal degeneration was characterized by accumulation of neurofibrillary material resembling neurofilaments. The findings are compared to other diseases with neurofibrillary accumulation in man and animals.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalActa Neuropathologica
Issue number1
StatePublished - Jan 1 1977
Externally publishedYes


  • Neurofibrillary degeneration
  • Spinal neuronal degeneration
  • Zebra siblings

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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