Neurofibrillary accumulation in the zebra (Equus burchelli)

Robert Higgins; M. Vandevelde; E. J. Hoff; J. E. Jagar; L. C. Cork; M. S. Silberman

doi:10.1007/BF00684532

Neurofibrillary accumulation in the zebra (Equus burchelli)

Robert Higgins, M. Vandevelde, E. J. Hoff, J. E. Jagar, L. C. Cork, M. S. Silberman

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord and in the lower brain stem. Ultrastructurally the neuronal degeneration was characterized by accumulation of neurofibrillary material resembling neurofilaments. The findings are compared to other diseases with neurofibrillary accumulation in man and animals.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Acta Neuropathologica
Volume	37
Issue number	1
DOIs	https://doi.org/10.1007/BF00684532
State	Published - Jan 1 1977
Externally published	Yes

Keywords

Neurofibrillary degeneration
Spinal neuronal degeneration
Zebra siblings

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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AU - Higgins, Robert

AU - Vandevelde, M.

AU - Hoff, E. J.

AU - Jagar, J. E.

AU - Cork, L. C.

AU - Silberman, M. S.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord and in the lower brain stem. Ultrastructurally the neuronal degeneration was characterized by accumulation of neurofibrillary material resembling neurofilaments. The findings are compared to other diseases with neurofibrillary accumulation in man and animals.

AB - Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord and in the lower brain stem. Ultrastructurally the neuronal degeneration was characterized by accumulation of neurofibrillary material resembling neurofilaments. The findings are compared to other diseases with neurofibrillary accumulation in man and animals.

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KW - Spinal neuronal degeneration

KW - Zebra siblings

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Neurofibrillary accumulation in the zebra (Equus burchelli)

Abstract

Keywords

ASJC Scopus subject areas

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