Neuroendocrinology of aggression

Brian C. Trainor, Randy J. Nelson

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

This chapter explains how aggression is a social interaction to determine the outcome of a conflict over resources. Aggressive behaviors take many forms, despite evidence that the regulatory factors and brain mechanisms are conserved across vertebrate species. Castrated animals are expected to show reduced aggression levels, whereas castrated animals with testosterone replaced via an implant are expected to display aggression levels similar to those of intact animals. Androgens such as testosterone can be converted to estrogens by the aromatase enzyme, and many brain regions known to regulate aggression express aromatase. Thus, in some cases, the effects of testosterone on aggression may actually be mediated by estrogenic metabolites. Dehydroepiandrosterone (DHEA) is an endogenous steroid that circulates at relatively high concentrations among humans. Similar to androgens, the relationship between glucocorticoids and aggressive behaviors is complex. The neuropeptides vasopressin and oxytocin have complex effects on aggressive behaviors. Vasopressin neurons in the bed nucleus of the stria terminalis (BNST) and medial amygdala send projections to the lateral septum.

Original languageEnglish (US)
Title of host publicationHandbook of Neuroendocrinology
PublisherElsevier Inc.
Pages509-520
Number of pages12
ISBN (Print)9780123750976
DOIs
StatePublished - 2012

Fingerprint

Neuroendocrinology
Aggression
Testosterone
Aromatase
Vasopressins
Androgens
Septal Nuclei
Dehydroepiandrosterone
Brain
Oxytocin
Interpersonal Relations
Amygdala
Neuropeptides
Glucocorticoids
Vertebrates
Estrogens
Steroids
Neurons
Enzymes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Trainor, B. C., & Nelson, R. J. (2012). Neuroendocrinology of aggression. In Handbook of Neuroendocrinology (pp. 509-520). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-375097-6.10022-8

Neuroendocrinology of aggression. / Trainor, Brian C.; Nelson, Randy J.

Handbook of Neuroendocrinology. Elsevier Inc., 2012. p. 509-520.

Research output: Chapter in Book/Report/Conference proceedingChapter

Trainor, BC & Nelson, RJ 2012, Neuroendocrinology of aggression. in Handbook of Neuroendocrinology. Elsevier Inc., pp. 509-520. https://doi.org/10.1016/B978-0-12-375097-6.10022-8
Trainor BC, Nelson RJ. Neuroendocrinology of aggression. In Handbook of Neuroendocrinology. Elsevier Inc. 2012. p. 509-520 https://doi.org/10.1016/B978-0-12-375097-6.10022-8
Trainor, Brian C. ; Nelson, Randy J. / Neuroendocrinology of aggression. Handbook of Neuroendocrinology. Elsevier Inc., 2012. pp. 509-520
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