Abstract
Neuroendocrine tumors of the pancreas are the second most common maLignant neoplasm of the pancreas. While they are less aggressive than ductal adenocarcinoma, they are often discovered at advanced cLinical stage, and overall survival is only 45% at 10 years. This tumor has recently received increased attention as pubLic figures such as Steve Jobs, cofounder of Apple Computer Corporation have succumbed to the disease. This article focuses on the cLinical and pathologic features of pancreatic neuroendocrine tumors, including diagnosis, classification, and treatment. In addition, genetic syndromes defined by or associated with the development of pancreatic neuroendocrine tumors are discussed. Finally, our current understanding of the molecular mechanisms underlying pancreatic neuroendocrine tumorigenesis is explored, and areas for future research are highLighted.
| Original language | English (US) |
|---|---|
| Title of host publication | Pathobiology of Human Disease |
| Subtitle of host publication | A Dynamic Encyclopedia of Disease Mechanisms |
| Publisher | Elsevier Inc. |
| Pages | 2284-2292 |
| Number of pages | 9 |
| ISBN (Electronic) | 9780123864567 |
| ISBN (Print) | 9780123864574 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
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Keywords
- ATRX
- Carcinoid
- Chromogranin
- DAXX
- Gastrinoma
- Glucagonoma
- InsuLinoma
- MTOR
- Multiple endocrine neoplasia
- Neuroendocrine
- Neurofibromatosis
- Pancreas
- Somatostatin
- Synaptophysin
- Tuberous sclerosis
- Von Hippel-Lindau
ASJC Scopus subject areas
- Medicine(all)
Cite this
Neuroendocrine Tumors of the Pancreas. / Matsukuma, Karen.
Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., 2014. p. 2284-2292.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Neuroendocrine Tumors of the Pancreas
AU - Matsukuma, Karen
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Neuroendocrine tumors of the pancreas are the second most common maLignant neoplasm of the pancreas. While they are less aggressive than ductal adenocarcinoma, they are often discovered at advanced cLinical stage, and overall survival is only 45% at 10 years. This tumor has recently received increased attention as pubLic figures such as Steve Jobs, cofounder of Apple Computer Corporation have succumbed to the disease. This article focuses on the cLinical and pathologic features of pancreatic neuroendocrine tumors, including diagnosis, classification, and treatment. In addition, genetic syndromes defined by or associated with the development of pancreatic neuroendocrine tumors are discussed. Finally, our current understanding of the molecular mechanisms underlying pancreatic neuroendocrine tumorigenesis is explored, and areas for future research are highLighted.
AB - Neuroendocrine tumors of the pancreas are the second most common maLignant neoplasm of the pancreas. While they are less aggressive than ductal adenocarcinoma, they are often discovered at advanced cLinical stage, and overall survival is only 45% at 10 years. This tumor has recently received increased attention as pubLic figures such as Steve Jobs, cofounder of Apple Computer Corporation have succumbed to the disease. This article focuses on the cLinical and pathologic features of pancreatic neuroendocrine tumors, including diagnosis, classification, and treatment. In addition, genetic syndromes defined by or associated with the development of pancreatic neuroendocrine tumors are discussed. Finally, our current understanding of the molecular mechanisms underlying pancreatic neuroendocrine tumorigenesis is explored, and areas for future research are highLighted.
KW - ATRX
KW - Carcinoid
KW - Chromogranin
KW - DAXX
KW - Gastrinoma
KW - Glucagonoma
KW - InsuLinoma
KW - MTOR
KW - Multiple endocrine neoplasia
KW - Neuroendocrine
KW - Neurofibromatosis
KW - Pancreas
KW - Somatostatin
KW - Synaptophysin
KW - Tuberous sclerosis
KW - Von Hippel-Lindau
UR - http://www.scopus.com/inward/record.url?scp=85043301409&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043301409&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-386456-7.04907-8
DO - 10.1016/B978-0-12-386456-7.04907-8
M3 - Chapter
AN - SCOPUS:85043301409
SN - 9780123864574
SP - 2284
EP - 2292
BT - Pathobiology of Human Disease
PB - Elsevier Inc.
ER -