Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network

Doug Redelman, Lisbeth A. Welniak, Dennis Taub, William J Murphy

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to accelerate the recovery of the immune response after chemotherapy and bone marrow transplantation and to enhance the restoration of immunity in individuals infected with HIV and in normal individuals with compromised immune systems associated with aging. As the mechanism of action of these hormones has been elucidated, it has become clear that they are integral members of the immunological cytokine/chemokine network and share regulatory mechanisms with a wide variety of cytokines and chemokines. The members of this cytokine network induce and can be regulated by members of the suppressor of cytokine signaling (SOCS) family of intracellular proteins. In order to take advantage of the potential beneficial effects of hormones such as GH or PRL, it is essential to take into consideration the overall cytokine network and the regulatory effects of SOCS proteins.

Original languageEnglish (US)
Pages (from-to)111-121
Number of pages11
JournalCellular Immunology
Volume252
Issue number1-2
DOIs
StatePublished - 2008
Externally publishedYes

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Keywords

  • Aging
  • Bone marrow transplantation (BMT)
  • Ghrelin
  • Growth hormone
  • HIV/AIDS
  • Immune recovery
  • Inflammation
  • Neuroendocrine hormone
  • Prolactin
  • Suppressors of cytokine signaling (SOCS) proteins

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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