Neurodevelopmental effect of aluminum in mice: Fostering studies

Mari S. Golub, Carl L Keen, M. Eric Gershwin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

In order to determine sensitive periods for induction of neurodevelopmental effects of aluminum (Al), mice were fed either 25 (control) or 1000 (high Al) μg Al/g diet (as Al lactate) from conception through lactation and litters were fostered either within or between groups at birth. Birth parameters were not influenced by Al intake. Food intake and body weight were 10%-12% lower during lactation in dams fed the high Al diets. Both gestation and lactation high Al exposure led to growth retardation in offspring beginning on day 10 postnatal; combined gestation and lactation exposure led to the biggest weight differential at weaning (23%). For neurobehavioral measures obtained at weaning, forelimb grasp strength was influenced by gestation high Al exposure, whereas negative geotaxis was influenced by lactation exposure, and hindlimb grasp and temperature sensitivity were influenced by both gestation and lactation exposure. Pup liver and brain manganese (Mn) and liver iron (Fe) concentrations at weaning were lower after high Al lactation exposure than in controls. Pup brain and liver Al concentrations were similar among the groups. These data show that mice are susceptible to neurodevelopmental effects of high maternal dietary Al intake during both gestation and lactation, and that high maternal intake can result in altered essential trace element metabolism in the offspring.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalNeurotoxicology and Teratology
Volume14
Issue number3
DOIs
StatePublished - 1992

Fingerprint

Foster Home Care
Aluminum
Lactation
Pregnancy
Weaning
Liver
Hand Strength
Nutrition
Brain
Mothers
Parturition
Diet
Forelimb
Trace Elements
Hindlimb
Manganese
Metabolism
Dams
Iron
Eating

Keywords

  • Aluminum
  • Aluminum lactate
  • Behavior
  • Brain
  • CNS
  • Development
  • Growth retardation
  • Lactation
  • Mice
  • Neurobehavioral
  • Pregnancy
  • Reflexes
  • Reproduction
  • Toxicity
  • Trace metals
  • Weanling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Neurodevelopmental effect of aluminum in mice : Fostering studies. / Golub, Mari S.; Keen, Carl L; Gershwin, M. Eric.

In: Neurotoxicology and Teratology, Vol. 14, No. 3, 1992, p. 177-182.

Research output: Contribution to journalArticle

@article{41730c4cb6694b889a223ab70b84b605,
title = "Neurodevelopmental effect of aluminum in mice: Fostering studies",
abstract = "In order to determine sensitive periods for induction of neurodevelopmental effects of aluminum (Al), mice were fed either 25 (control) or 1000 (high Al) μg Al/g diet (as Al lactate) from conception through lactation and litters were fostered either within or between groups at birth. Birth parameters were not influenced by Al intake. Food intake and body weight were 10{\%}-12{\%} lower during lactation in dams fed the high Al diets. Both gestation and lactation high Al exposure led to growth retardation in offspring beginning on day 10 postnatal; combined gestation and lactation exposure led to the biggest weight differential at weaning (23{\%}). For neurobehavioral measures obtained at weaning, forelimb grasp strength was influenced by gestation high Al exposure, whereas negative geotaxis was influenced by lactation exposure, and hindlimb grasp and temperature sensitivity were influenced by both gestation and lactation exposure. Pup liver and brain manganese (Mn) and liver iron (Fe) concentrations at weaning were lower after high Al lactation exposure than in controls. Pup brain and liver Al concentrations were similar among the groups. These data show that mice are susceptible to neurodevelopmental effects of high maternal dietary Al intake during both gestation and lactation, and that high maternal intake can result in altered essential trace element metabolism in the offspring.",
keywords = "Aluminum, Aluminum lactate, Behavior, Brain, CNS, Development, Growth retardation, Lactation, Mice, Neurobehavioral, Pregnancy, Reflexes, Reproduction, Toxicity, Trace metals, Weanling",
author = "Golub, {Mari S.} and Keen, {Carl L} and Gershwin, {M. Eric}",
year = "1992",
doi = "10.1016/0892-0362(92)90013-Z",
language = "English (US)",
volume = "14",
pages = "177--182",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Neurodevelopmental effect of aluminum in mice

T2 - Fostering studies

AU - Golub, Mari S.

AU - Keen, Carl L

AU - Gershwin, M. Eric

PY - 1992

Y1 - 1992

N2 - In order to determine sensitive periods for induction of neurodevelopmental effects of aluminum (Al), mice were fed either 25 (control) or 1000 (high Al) μg Al/g diet (as Al lactate) from conception through lactation and litters were fostered either within or between groups at birth. Birth parameters were not influenced by Al intake. Food intake and body weight were 10%-12% lower during lactation in dams fed the high Al diets. Both gestation and lactation high Al exposure led to growth retardation in offspring beginning on day 10 postnatal; combined gestation and lactation exposure led to the biggest weight differential at weaning (23%). For neurobehavioral measures obtained at weaning, forelimb grasp strength was influenced by gestation high Al exposure, whereas negative geotaxis was influenced by lactation exposure, and hindlimb grasp and temperature sensitivity were influenced by both gestation and lactation exposure. Pup liver and brain manganese (Mn) and liver iron (Fe) concentrations at weaning were lower after high Al lactation exposure than in controls. Pup brain and liver Al concentrations were similar among the groups. These data show that mice are susceptible to neurodevelopmental effects of high maternal dietary Al intake during both gestation and lactation, and that high maternal intake can result in altered essential trace element metabolism in the offspring.

AB - In order to determine sensitive periods for induction of neurodevelopmental effects of aluminum (Al), mice were fed either 25 (control) or 1000 (high Al) μg Al/g diet (as Al lactate) from conception through lactation and litters were fostered either within or between groups at birth. Birth parameters were not influenced by Al intake. Food intake and body weight were 10%-12% lower during lactation in dams fed the high Al diets. Both gestation and lactation high Al exposure led to growth retardation in offspring beginning on day 10 postnatal; combined gestation and lactation exposure led to the biggest weight differential at weaning (23%). For neurobehavioral measures obtained at weaning, forelimb grasp strength was influenced by gestation high Al exposure, whereas negative geotaxis was influenced by lactation exposure, and hindlimb grasp and temperature sensitivity were influenced by both gestation and lactation exposure. Pup liver and brain manganese (Mn) and liver iron (Fe) concentrations at weaning were lower after high Al lactation exposure than in controls. Pup brain and liver Al concentrations were similar among the groups. These data show that mice are susceptible to neurodevelopmental effects of high maternal dietary Al intake during both gestation and lactation, and that high maternal intake can result in altered essential trace element metabolism in the offspring.

KW - Aluminum

KW - Aluminum lactate

KW - Behavior

KW - Brain

KW - CNS

KW - Development

KW - Growth retardation

KW - Lactation

KW - Mice

KW - Neurobehavioral

KW - Pregnancy

KW - Reflexes

KW - Reproduction

KW - Toxicity

KW - Trace metals

KW - Weanling

UR - http://www.scopus.com/inward/record.url?scp=0026686714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026686714&partnerID=8YFLogxK

U2 - 10.1016/0892-0362(92)90013-Z

DO - 10.1016/0892-0362(92)90013-Z

M3 - Article

C2 - 1635538

AN - SCOPUS:0026686714

VL - 14

SP - 177

EP - 182

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 3

ER -