Neurodevelopmental and behavioral outcomes in extremely premature neonates with ventriculomegaly in the absence of periventricular-intraventricular hemorrhage

Athina Pappas, Ira Adams-Chapman, Seetha Shankaran, Scott A. McDonald, Barbara J. Stoll, Abbot R. Laptook, Waldemar A. Carlo, Krisa P. Van Meurs, Susan R. Hintz, Martha D. Carlson, Jane E. Brumbaugh, Michele C. Walsh, Myra H. Wyckoff, Abhik Das, Rosemary D. Higgins, Michael S. Caplan, Richard A. Polin, Martin Keszler, William Oh, Betty R. Vohr & 285 others Angelita M. Hensman, Kristin M. Basso, Barbara Alksninis, Robert Burke, Melinda Caskey, Andrea Halbrook, Katharine Johnson, Mary Lenore Keszler, Theresa M. Leach, Bonnie E. Stephens, Suzy Ventura, Victoria E. Watson, Avroy A. Fanaroff, Anna Marie Hibbs, Deanne E. Wilson-Costello, Nancy S. Newman, Allison F. Payne, Bonnie S. Siner, Monika Bhola, Gulgun Yalcinkaya, Harriet G. Friedman, William E. Truog, Eugenia K. Pallotto, Howard W. Kilbride, Cheri Gauldin, Anne Holmes, Kathy Johnson, Kurt Schibler, Edward F. Donovan, Cathy Grisby, Barbara Alexander, Kate Bridges, Estelle E. Fischer, Teresa L. Gratton, Holly L. Mincey, Greg Muthig, Jody Hessling, Lenora D. Jackson, Kristin Kirker, Kimberly Yolton, Ronald N. Goldberg, C. Michael Cotten, Ricki F. Goldstein, Kathryn E. Gustafson, Joanne Finkle, Patricia L. Ashley, William F. Malcolm, Kathy J. Auten, Kimberley A. Fisher, Katherine A. Foy, Sandra Grimes, Melody B. Lohmeyer, Matthew M. Laughon, Carl L. Bose, Janice Bernhardt, Gennie Bose, Janice K. Wereszczak, David P. Carlton, Ellen C. Hale, Yvonne C. Loggins, Maureen Mulligan LaRossa, Sheena L. Carter, Stephanie Wilson Archer, Gregory M. Sokol, Brenda B. Poindexter, Anna M. Dusick, Lu Ann Papile, Dianne E. Herron, Lucy C. Miller, Carolyn Lytle, Ann B. Cook, Heike M. Minnich, Abbey C. Hines, Leslie Dawn Wilson, Faithe Hamer, Pablo J. Sánchez, Leif D. Nelin, Sudarshan R. Jadcherla, Keith Owen Yeates, Patricia Luzader, Christine A. Fortney, Gail E. Besner, Nehal A. Parikh, Dennis Wallace, W. Kenneth Poole, Jeanette O.Donnell Auman, Margaret M. Crawford, Marie G. Gantz, Jamie E. Newman, Carolyn M. Petrie Huitema, Kristin M. Zaterka-Baxter, David K. Stevenson, M. Bethany Ball, Marian M. Adams, Barbara Bentley, Elizabeth Bruno, Maria Elena DeAnda, Anne M. DeBattista, Lynne C. Huffman, Jean G. Kohn, Casey E. Krueger, Andrew W. Palmquist, Melinda S. Proud, Brian Tang, Hali E. Weiss, Ivan D. Frantz, John M. Fiascone, Elisabeth C. McGowan, Brenda L. MacKinnon, Ana K. Brussa, Anne Furey, Ellen Nylen, Cecelia E. Sibley, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Monica V. Collins, Shirley S. Cosby, Vivien A. Phillips, Fred J. Biasini, Kristy Domnanovich, Kristen C. Johnston, Carin Kiser, Sara Kryzwanski, Kathleen G. Nelson, Cryshelle S. Patterson, Richard V. Rector, Leslie Rodrigues, Sarah Ryan, Leigh Ann Smith, Amanda D. Soong, Sally Whitley, Uday Devaskar, Meena Garg, Isabell B. Purdy, Teresa Chanlaw, Rachel Geller, Neil N. Finer, David Kaegi, Maynard R. Rasmussen, Yvonne E. Vaucher, Kathy Arnell, Clarence Demetrio, Martha G. Fuller, Chris Henderson, Wade Rich, Radmila West, Edward F. Bell, Dan L. Ellsbury, John A. Widness, Tarah T. Colaizy, Michael J. Acarregui, Karen J. Johnson, Donia B. Campbell, Diane L. Eastman, Jacky R. Walker, Shahnaz Duara, Charles R. Bauer, Ruth Everett-Thomas, Sylvia Fajardo-Hiriart, Arielle Rigaud, Maria Calejo, Silvia M. Frade Eguaras, Michelle Harwood Berkowits, Andrea Garcia, Helina Pierre, Alexandra Stoerger, Kristi L. Watterberg, Robin K. Ohls, Andrea H. Duncan, Janell F. Fuller, Conra Backstrom Lacy, Sandra Brown, Carol Hartenberger, Jean R. Lowe, Rebecca A. Montman, Barbara Schmidt, Haresh Kirpalani, Sara B. DeMauro, Aasma S. Chaudhary, Soraya Abbasi, Toni Mancini, Dara M. Cucinotta, Judy C. Bernbaum, Marsha Gerdes, Hallam Hurt, Carl T. D'Angio, Dale L. Phelps, Ronnie Guillet, Gary J. Myers, Linda J. Reubens, Erica Burnell, Diane Hust, Julie Babish Johnson, Julianne Hunn, Rosemary L. Jensen, Emily Kushner, Deanna Maffett, Joan Merzbach, Holly I.M. Wadkins, Kelley Yost, Lauren Zwetsch, Satyanarayana Lakshminrusimha, Anne Marie Reynolds, Farooq Osman, Ashley Williams, Karen Wynn, Kathleen A. Kennedy, Jon E. Tyson, Georgia E. McDavid, Nora I. Alaniz, Katrina Burson, Patricia W. Evans, Charles Green, Beverly Foley Harris, Margarita Jiminez, Anna E. Lis, Sarah Martin, Brenda H. Morris, M. Layne Poundstone, Peggy Robichaux, Saba Siddiki, Maegan C. Simmons, Patti L. Pierce Tate, Sharon L. Wright, Luc P. Brion, Roy J. Heyne, Walid A. Salhab, Charles R. Rosenfeld, Diana M. Vasil, Sally S. Adams, Lijun Chen, Alicia Guzman, Gaynelle Hensley, Elizabeth T. Heyne, Melissa H. Leps, Linda A. Madden, Nancy A. Miller, Janet S. Morgan, Lizette E. Torres, Catherine Twell Boatman, Roger G. Faix, Bradley A. Yoder, Anna Bodnar, Karen A. Osborne, Shawna Baker, Karie Bird, Jill Burnett, Laura Cole, Jennifer J. Jensen, Cynthia Spencer, Michael Steffen, Kimberlee Weaver-Lewis, Sarah Winter, Karen Zanetti, T. Michael O'Shea, Robert G. Dillard, Lisa K. Washburn, Barbara G. Jackson, Nancy Peters, Korinne Chiu, Deborah Evans Allred, Donald J. Goldstein, Raquel Halfond, Carroll Peterson, Ellen L. Waldrep, Cherrie D. Welch, Melissa Whalen Morris, Gail Wiley Hounshell, John Barks, Rebecca Bara, Angela Argento, Laura A. Goldston, Mary Johnson, Mary Christensen, Stephanie Wiggins, Richard A. Ehrenkranz, Harris Jacobs, Christine G. Butler, Patricia Cervone, Sheila Greisman, Monica Konstantino, Joann Poulsen, Janet Taft, Joanne Williams, Elaine Romano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

IMPORTANCE Studies of cranial ultrasonography and early childhood outcomes among cohorts of extremely preterm neonates have linked periventricular-intraventricular hemorrhage and cystic periventricular leukomalacia with adverse neurodevelopmental outcomes. However, the association between nonhemorrhagic ventriculomegaly and neurodevelopmental and behavioral outcomes is not fully understood. OBJECTIVE To characterize the outcomes of extremely preterm neonates younger than 27 weeks' gestational age who experienced nonhemorrhagic ventriculomegaly that was detected prior to 36 weeks' postmenstrual age. DESIGN, SETTING, AND PARTICIPANTS This longitudinal observational studywas conducted at 16 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants born prior to 27 weeks' gestational age in any network facility between July 1, 2006, and June 30, 2011, were included if they had a cranial ultrasonogram performed prior to 36 weeks' postmenstrual age. Comparisons were made between those with ventriculomegaly and those with normal cranial sonograms. Data analysis was completed from August 2013 to August 2017. MAIN OUTCOMES AND MEASURES The main outcomewas neurodevelopmental impairment, defined as a Bayley Scales of Infant and Toddler Development III cognitive score less than 70, moderate/severe cerebral palsy, a Gross Motor Function Classification System score of level 2 or more, vision impairment, or hearing impairment. Secondary outcomes included Bayley Scales of Infant and Toddler Development III subscores, components of neurodevelopmental impairment, behavioral outcomes, and death/neurodevelopmental impairment. Logistic regression was used to evaluate the association of ventriculomegaly with adverse outcomes while controlling for potentially confounding variables and center differences as a random effect. Linear regression was used similarly for continuous outcomes. RESULTS Of4193neonateswithultrasonographydata,300hadnonhemorrhagicventriculomegaly (7%); 3045 had normal cranial ultrasonograms (73%), 775 had periventricular-intraventricular hemorrhage (18.5%), and 73 had cystic periventricular leukomalacia (1.7%). Outcomeswere available for3008of3345neonateswithventriculomegaly ornormalscans(90%).Comparedwith normal cranial ultrasonograms, ventriculomegalywas associated with lower gestational age, male sex, and bronchopulmonary dysplasia, late-onset sepsis, meningitis, necrotizing enterocolitis, and stage 3 retinopathy of prematurity. After adjustment, neonates with ventriculomegaly had higher odds of neurodevelopmental impairment (odds ratio [OR], 3.07; 95%CI, 2.13-4.43), cognitive impairment (OR, 3.23; 95%CI, 2.09-4.99), moderate/severe cerebral palsy (OR, 3.68; 95%CI, 2.08-6.51),death/neurodevelopmentalimpairment(OR,2.17;95%CI,1.62-2.91),butnotdeathalone (OR, 1.09; 95%CI,0.76-1.57). Behavioral outcomes did not differ. CONCLUSIONS AND RELEVANCE Nonhemorrhagic ventriculomegaly is associated with increased odds of neurodevelopmental impairment among extremely preterm neonates.

Original languageEnglish (US)
Pages (from-to)32-42
Number of pages11
JournalJAMA Pediatrics
Volume172
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

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Odds Ratio
Newborn Infant
Hemorrhage
Periventricular Leukomalacia
Gestational Age
Cerebral Palsy
Child Development
National Institute of Child Health and Human Development (U.S.)
Social Adjustment
Bronchopulmonary Dysplasia
Retinopathy of Prematurity
Necrotizing Enterocolitis
Confounding Factors (Epidemiology)
Hearing Loss
Meningitis
Linear Models
Ultrasonography
Sepsis
Logistic Models
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Neurodevelopmental and behavioral outcomes in extremely premature neonates with ventriculomegaly in the absence of periventricular-intraventricular hemorrhage. / Pappas, Athina; Adams-Chapman, Ira; Shankaran, Seetha; McDonald, Scott A.; Stoll, Barbara J.; Laptook, Abbot R.; Carlo, Waldemar A.; Van Meurs, Krisa P.; Hintz, Susan R.; Carlson, Martha D.; Brumbaugh, Jane E.; Walsh, Michele C.; Wyckoff, Myra H.; Das, Abhik; Higgins, Rosemary D.; Caplan, Michael S.; Polin, Richard A.; Keszler, Martin; Oh, William; Vohr, Betty R.; Hensman, Angelita M.; Basso, Kristin M.; Alksninis, Barbara; Burke, Robert; Caskey, Melinda; Halbrook, Andrea; Johnson, Katharine; Keszler, Mary Lenore; Leach, Theresa M.; Stephens, Bonnie E.; Ventura, Suzy; Watson, Victoria E.; Fanaroff, Avroy A.; Hibbs, Anna Marie; Wilson-Costello, Deanne E.; Newman, Nancy S.; Payne, Allison F.; Siner, Bonnie S.; Bhola, Monika; Yalcinkaya, Gulgun; Friedman, Harriet G.; Truog, William E.; Pallotto, Eugenia K.; Kilbride, Howard W.; Gauldin, Cheri; Holmes, Anne; Johnson, Kathy; Schibler, Kurt; Donovan, Edward F.; Grisby, Cathy; Alexander, Barbara; Bridges, Kate; Fischer, Estelle E.; Gratton, Teresa L.; Mincey, Holly L.; Muthig, Greg; Hessling, Jody; Jackson, Lenora D.; Kirker, Kristin; Yolton, Kimberly; Goldberg, Ronald N.; Cotten, C. Michael; Goldstein, Ricki F.; Gustafson, Kathryn E.; Finkle, Joanne; Ashley, Patricia L.; Malcolm, William F.; Auten, Kathy J.; Fisher, Kimberley A.; Foy, Katherine A.; Grimes, Sandra; Lohmeyer, Melody B.; Laughon, Matthew M.; Bose, Carl L.; Bernhardt, Janice; Bose, Gennie; Wereszczak, Janice K.; Carlton, David P.; Hale, Ellen C.; Loggins, Yvonne C.; LaRossa, Maureen Mulligan; Carter, Sheena L.; Archer, Stephanie Wilson; Sokol, Gregory M.; Poindexter, Brenda B.; Dusick, Anna M.; Papile, Lu Ann; Herron, Dianne E.; Miller, Lucy C.; Lytle, Carolyn; Cook, Ann B.; Minnich, Heike M.; Hines, Abbey C.; Wilson, Leslie Dawn; Hamer, Faithe; Sánchez, Pablo J.; Nelin, Leif D.; Jadcherla, Sudarshan R.; Yeates, Keith Owen; Luzader, Patricia; Fortney, Christine A.; Besner, Gail E.; Parikh, Nehal A.; Wallace, Dennis; Poole, W. Kenneth; Auman, Jeanette O.Donnell; Crawford, Margaret M.; Gantz, Marie G.; Newman, Jamie E.; Petrie Huitema, Carolyn M.; Zaterka-Baxter, Kristin M.; Stevenson, David K.; Ball, M. Bethany; Adams, Marian M.; Bentley, Barbara; Bruno, Elizabeth; DeAnda, Maria Elena; DeBattista, Anne M.; Huffman, Lynne C.; Kohn, Jean G.; Krueger, Casey E.; Palmquist, Andrew W.; Proud, Melinda S.; Tang, Brian; Weiss, Hali E.; Frantz, Ivan D.; Fiascone, John M.; McGowan, Elisabeth C.; MacKinnon, Brenda L.; Brussa, Ana K.; Furey, Anne; Nylen, Ellen; Sibley, Cecelia E.; Ambalavanan, Namasivayam; Peralta-Carcelen, Myriam; Collins, Monica V.; Cosby, Shirley S.; Phillips, Vivien A.; Biasini, Fred J.; Domnanovich, Kristy; Johnston, Kristen C.; Kiser, Carin; Kryzwanski, Sara; Nelson, Kathleen G.; Patterson, Cryshelle S.; Rector, Richard V.; Rodrigues, Leslie; Ryan, Sarah; Smith, Leigh Ann; Soong, Amanda D.; Whitley, Sally; Devaskar, Uday; Garg, Meena; Purdy, Isabell B.; Chanlaw, Teresa; Geller, Rachel; Finer, Neil N.; Kaegi, David; Rasmussen, Maynard R.; Vaucher, Yvonne E.; Arnell, Kathy; Demetrio, Clarence; Fuller, Martha G.; Henderson, Chris; Rich, Wade; West, Radmila; Bell, Edward F.; Ellsbury, Dan L.; Widness, John A.; Colaizy, Tarah T.; Acarregui, Michael J.; Johnson, Karen J.; Campbell, Donia B.; Eastman, Diane L.; Walker, Jacky R.; Duara, Shahnaz; Bauer, Charles R.; Everett-Thomas, Ruth; Fajardo-Hiriart, Sylvia; Rigaud, Arielle; Calejo, Maria; Frade Eguaras, Silvia M.; Berkowits, Michelle Harwood; Garcia, Andrea; Pierre, Helina; Stoerger, Alexandra; Watterberg, Kristi L.; Ohls, Robin K.; Duncan, Andrea H.; Fuller, Janell F.; Lacy, Conra Backstrom; Brown, Sandra; Hartenberger, Carol; Lowe, Jean R.; Montman, Rebecca A.; Schmidt, Barbara; Kirpalani, Haresh; DeMauro, Sara B.; Chaudhary, Aasma S.; Abbasi, Soraya; Mancini, Toni; Cucinotta, Dara M.; Bernbaum, Judy C.; Gerdes, Marsha; Hurt, Hallam; D'Angio, Carl T.; Phelps, Dale L.; Guillet, Ronnie; Myers, Gary J.; Reubens, Linda J.; Burnell, Erica; Hust, Diane; Johnson, Julie Babish; Hunn, Julianne; Jensen, Rosemary L.; Kushner, Emily; Maffett, Deanna; Merzbach, Joan; Wadkins, Holly I.M.; Yost, Kelley; Zwetsch, Lauren; Lakshminrusimha, Satyanarayana; Reynolds, Anne Marie; Osman, Farooq; Williams, Ashley; Wynn, Karen; Kennedy, Kathleen A.; Tyson, Jon E.; McDavid, Georgia E.; Alaniz, Nora I.; Burson, Katrina; Evans, Patricia W.; Green, Charles; Harris, Beverly Foley; Jiminez, Margarita; Lis, Anna E.; Martin, Sarah; Morris, Brenda H.; Poundstone, M. Layne; Robichaux, Peggy; Siddiki, Saba; Simmons, Maegan C.; Pierce Tate, Patti L.; Wright, Sharon L.; Brion, Luc P.; Heyne, Roy J.; Salhab, Walid A.; Rosenfeld, Charles R.; Vasil, Diana M.; Adams, Sally S.; Chen, Lijun; Guzman, Alicia; Hensley, Gaynelle; Heyne, Elizabeth T.; Leps, Melissa H.; Madden, Linda A.; Miller, Nancy A.; Morgan, Janet S.; Torres, Lizette E.; Boatman, Catherine Twell; Faix, Roger G.; Yoder, Bradley A.; Bodnar, Anna; Osborne, Karen A.; Baker, Shawna; Bird, Karie; Burnett, Jill; Cole, Laura; Jensen, Jennifer J.; Spencer, Cynthia; Steffen, Michael; Weaver-Lewis, Kimberlee; Winter, Sarah; Zanetti, Karen; O'Shea, T. Michael; Dillard, Robert G.; Washburn, Lisa K.; Jackson, Barbara G.; Peters, Nancy; Chiu, Korinne; Allred, Deborah Evans; Goldstein, Donald J.; Halfond, Raquel; Peterson, Carroll; Waldrep, Ellen L.; Welch, Cherrie D.; Morris, Melissa Whalen; Hounshell, Gail Wiley; Barks, John; Bara, Rebecca; Argento, Angela; Goldston, Laura A.; Johnson, Mary; Christensen, Mary; Wiggins, Stephanie; Ehrenkranz, Richard A.; Jacobs, Harris; Butler, Christine G.; Cervone, Patricia; Greisman, Sheila; Konstantino, Monica; Poulsen, Joann; Taft, Janet; Williams, Joanne; Romano, Elaine.

In: JAMA Pediatrics, Vol. 172, No. 1, 01.01.2018, p. 32-42.

Research output: Contribution to journalArticle

Pappas, A, Adams-Chapman, I, Shankaran, S, McDonald, SA, Stoll, BJ, Laptook, AR, Carlo, WA, Van Meurs, KP, Hintz, SR, Carlson, MD, Brumbaugh, JE, Walsh, MC, Wyckoff, MH, Das, A, Higgins, RD, Caplan, MS, Polin, RA, Keszler, M, Oh, W, Vohr, BR, Hensman, AM, Basso, KM, Alksninis, B, Burke, R, Caskey, M, Halbrook, A, Johnson, K, Keszler, ML, Leach, TM, Stephens, BE, Ventura, S, Watson, VE, Fanaroff, AA, Hibbs, AM, Wilson-Costello, DE, Newman, NS, Payne, AF, Siner, BS, Bhola, M, Yalcinkaya, G, Friedman, HG, Truog, WE, Pallotto, EK, Kilbride, HW, Gauldin, C, Holmes, A, Johnson, K, Schibler, K, Donovan, EF, Grisby, C, Alexander, B, Bridges, K, Fischer, EE, Gratton, TL, Mincey, HL, Muthig, G, Hessling, J, Jackson, LD, Kirker, K, Yolton, K, Goldberg, RN, Cotten, CM, Goldstein, RF, Gustafson, KE, Finkle, J, Ashley, PL, Malcolm, WF, Auten, KJ, Fisher, KA, Foy, KA, Grimes, S, Lohmeyer, MB, Laughon, MM, Bose, CL, Bernhardt, J, Bose, G, Wereszczak, JK, Carlton, DP, Hale, EC, Loggins, YC, LaRossa, MM, Carter, SL, Archer, SW, Sokol, GM, Poindexter, BB, Dusick, AM, Papile, LA, Herron, DE, Miller, LC, Lytle, C, Cook, AB, Minnich, HM, Hines, AC, Wilson, LD, Hamer, F, Sánchez, PJ, Nelin, LD, Jadcherla, SR, Yeates, KO, Luzader, P, Fortney, CA, Besner, GE, Parikh, NA, Wallace, D, Poole, WK, Auman, JOD, Crawford, MM, Gantz, MG, Newman, JE, Petrie Huitema, CM, Zaterka-Baxter, KM, Stevenson, DK, Ball, MB, Adams, MM, Bentley, B, Bruno, E, DeAnda, ME, DeBattista, AM, Huffman, LC, Kohn, JG, Krueger, CE, Palmquist, AW, Proud, MS, Tang, B, Weiss, HE, Frantz, ID, Fiascone, JM, McGowan, EC, MacKinnon, BL, Brussa, AK, Furey, A, Nylen, E, Sibley, CE, Ambalavanan, N, Peralta-Carcelen, M, Collins, MV, Cosby, SS, Phillips, VA, Biasini, FJ, Domnanovich, K, Johnston, KC, Kiser, C, Kryzwanski, S, Nelson, KG, Patterson, CS, Rector, RV, Rodrigues, L, Ryan, S, Smith, LA, Soong, AD, Whitley, S, Devaskar, U, Garg, M, Purdy, IB, Chanlaw, T, Geller, R, Finer, NN, Kaegi, D, Rasmussen, MR, Vaucher, YE, Arnell, K, Demetrio, C, Fuller, MG, Henderson, C, Rich, W, West, R, Bell, EF, Ellsbury, DL, Widness, JA, Colaizy, TT, Acarregui, MJ, Johnson, KJ, Campbell, DB, Eastman, DL, Walker, JR, Duara, S, Bauer, CR, Everett-Thomas, R, Fajardo-Hiriart, S, Rigaud, A, Calejo, M, Frade Eguaras, SM, Berkowits, MH, Garcia, A, Pierre, H, Stoerger, A, Watterberg, KL, Ohls, RK, Duncan, AH, Fuller, JF, Lacy, CB, Brown, S, Hartenberger, C, Lowe, JR, Montman, RA, Schmidt, B, Kirpalani, H, DeMauro, SB, Chaudhary, AS, Abbasi, S, Mancini, T, Cucinotta, DM, Bernbaum, JC, Gerdes, M, Hurt, H, D'Angio, CT, Phelps, DL, Guillet, R, Myers, GJ, Reubens, LJ, Burnell, E, Hust, D, Johnson, JB, Hunn, J, Jensen, RL, Kushner, E, Maffett, D, Merzbach, J, Wadkins, HIM, Yost, K, Zwetsch, L, Lakshminrusimha, S, Reynolds, AM, Osman, F, Williams, A, Wynn, K, Kennedy, KA, Tyson, JE, McDavid, GE, Alaniz, NI, Burson, K, Evans, PW, Green, C, Harris, BF, Jiminez, M, Lis, AE, Martin, S, Morris, BH, Poundstone, ML, Robichaux, P, Siddiki, S, Simmons, MC, Pierce Tate, PL, Wright, SL, Brion, LP, Heyne, RJ, Salhab, WA, Rosenfeld, CR, Vasil, DM, Adams, SS, Chen, L, Guzman, A, Hensley, G, Heyne, ET, Leps, MH, Madden, LA, Miller, NA, Morgan, JS, Torres, LE, Boatman, CT, Faix, RG, Yoder, BA, Bodnar, A, Osborne, KA, Baker, S, Bird, K, Burnett, J, Cole, L, Jensen, JJ, Spencer, C, Steffen, M, Weaver-Lewis, K, Winter, S, Zanetti, K, O'Shea, TM, Dillard, RG, Washburn, LK, Jackson, BG, Peters, N, Chiu, K, Allred, DE, Goldstein, DJ, Halfond, R, Peterson, C, Waldrep, EL, Welch, CD, Morris, MW, Hounshell, GW, Barks, J, Bara, R, Argento, A, Goldston, LA, Johnson, M, Christensen, M, Wiggins, S, Ehrenkranz, RA, Jacobs, H, Butler, CG, Cervone, P, Greisman, S, Konstantino, M, Poulsen, J, Taft, J, Williams, J & Romano, E 2018, 'Neurodevelopmental and behavioral outcomes in extremely premature neonates with ventriculomegaly in the absence of periventricular-intraventricular hemorrhage', JAMA Pediatrics, vol. 172, no. 1, pp. 32-42. https://doi.org/10.1001/jamapediatrics.2017.3545
Pappas, Athina ; Adams-Chapman, Ira ; Shankaran, Seetha ; McDonald, Scott A. ; Stoll, Barbara J. ; Laptook, Abbot R. ; Carlo, Waldemar A. ; Van Meurs, Krisa P. ; Hintz, Susan R. ; Carlson, Martha D. ; Brumbaugh, Jane E. ; Walsh, Michele C. ; Wyckoff, Myra H. ; Das, Abhik ; Higgins, Rosemary D. ; Caplan, Michael S. ; Polin, Richard A. ; Keszler, Martin ; Oh, William ; Vohr, Betty R. ; Hensman, Angelita M. ; Basso, Kristin M. ; Alksninis, Barbara ; Burke, Robert ; Caskey, Melinda ; Halbrook, Andrea ; Johnson, Katharine ; Keszler, Mary Lenore ; Leach, Theresa M. ; Stephens, Bonnie E. ; Ventura, Suzy ; Watson, Victoria E. ; Fanaroff, Avroy A. ; Hibbs, Anna Marie ; Wilson-Costello, Deanne E. ; Newman, Nancy S. ; Payne, Allison F. ; Siner, Bonnie S. ; Bhola, Monika ; Yalcinkaya, Gulgun ; Friedman, Harriet G. ; Truog, William E. ; Pallotto, Eugenia K. ; Kilbride, Howard W. ; Gauldin, Cheri ; Holmes, Anne ; Johnson, Kathy ; Schibler, Kurt ; Donovan, Edward F. ; Grisby, Cathy ; Alexander, Barbara ; Bridges, Kate ; Fischer, Estelle E. ; Gratton, Teresa L. ; Mincey, Holly L. ; Muthig, Greg ; Hessling, Jody ; Jackson, Lenora D. ; Kirker, Kristin ; Yolton, Kimberly ; Goldberg, Ronald N. ; Cotten, C. Michael ; Goldstein, Ricki F. ; Gustafson, Kathryn E. ; Finkle, Joanne ; Ashley, Patricia L. ; Malcolm, William F. ; Auten, Kathy J. ; Fisher, Kimberley A. ; Foy, Katherine A. ; Grimes, Sandra ; Lohmeyer, Melody B. ; Laughon, Matthew M. ; Bose, Carl L. ; Bernhardt, Janice ; Bose, Gennie ; Wereszczak, Janice K. ; Carlton, David P. ; Hale, Ellen C. ; Loggins, Yvonne C. ; LaRossa, Maureen Mulligan ; Carter, Sheena L. ; Archer, Stephanie Wilson ; Sokol, Gregory M. ; Poindexter, Brenda B. ; Dusick, Anna M. ; Papile, Lu Ann ; Herron, Dianne E. ; Miller, Lucy C. ; Lytle, Carolyn ; Cook, Ann B. ; Minnich, Heike M. ; Hines, Abbey C. ; Wilson, Leslie Dawn ; Hamer, Faithe ; Sánchez, Pablo J. ; Nelin, Leif D. ; Jadcherla, Sudarshan R. ; Yeates, Keith Owen ; Luzader, Patricia ; Fortney, Christine A. ; Besner, Gail E. ; Parikh, Nehal A. ; Wallace, Dennis ; Poole, W. Kenneth ; Auman, Jeanette O.Donnell ; Crawford, Margaret M. ; Gantz, Marie G. ; Newman, Jamie E. ; Petrie Huitema, Carolyn M. ; Zaterka-Baxter, Kristin M. ; Stevenson, David K. ; Ball, M. Bethany ; Adams, Marian M. ; Bentley, Barbara ; Bruno, Elizabeth ; DeAnda, Maria Elena ; DeBattista, Anne M. ; Huffman, Lynne C. ; Kohn, Jean G. ; Krueger, Casey E. ; Palmquist, Andrew W. ; Proud, Melinda S. ; Tang, Brian ; Weiss, Hali E. ; Frantz, Ivan D. ; Fiascone, John M. ; McGowan, Elisabeth C. ; MacKinnon, Brenda L. ; Brussa, Ana K. ; Furey, Anne ; Nylen, Ellen ; Sibley, Cecelia E. ; Ambalavanan, Namasivayam ; Peralta-Carcelen, Myriam ; Collins, Monica V. ; Cosby, Shirley S. ; Phillips, Vivien A. ; Biasini, Fred J. ; Domnanovich, Kristy ; Johnston, Kristen C. ; Kiser, Carin ; Kryzwanski, Sara ; Nelson, Kathleen G. ; Patterson, Cryshelle S. ; Rector, Richard V. ; Rodrigues, Leslie ; Ryan, Sarah ; Smith, Leigh Ann ; Soong, Amanda D. ; Whitley, Sally ; Devaskar, Uday ; Garg, Meena ; Purdy, Isabell B. ; Chanlaw, Teresa ; Geller, Rachel ; Finer, Neil N. ; Kaegi, David ; Rasmussen, Maynard R. ; Vaucher, Yvonne E. ; Arnell, Kathy ; Demetrio, Clarence ; Fuller, Martha G. ; Henderson, Chris ; Rich, Wade ; West, Radmila ; Bell, Edward F. ; Ellsbury, Dan L. ; Widness, John A. ; Colaizy, Tarah T. ; Acarregui, Michael J. ; Johnson, Karen J. ; Campbell, Donia B. ; Eastman, Diane L. ; Walker, Jacky R. ; Duara, Shahnaz ; Bauer, Charles R. ; Everett-Thomas, Ruth ; Fajardo-Hiriart, Sylvia ; Rigaud, Arielle ; Calejo, Maria ; Frade Eguaras, Silvia M. ; Berkowits, Michelle Harwood ; Garcia, Andrea ; Pierre, Helina ; Stoerger, Alexandra ; Watterberg, Kristi L. ; Ohls, Robin K. ; Duncan, Andrea H. ; Fuller, Janell F. ; Lacy, Conra Backstrom ; Brown, Sandra ; Hartenberger, Carol ; Lowe, Jean R. ; Montman, Rebecca A. ; Schmidt, Barbara ; Kirpalani, Haresh ; DeMauro, Sara B. ; Chaudhary, Aasma S. ; Abbasi, Soraya ; Mancini, Toni ; Cucinotta, Dara M. ; Bernbaum, Judy C. ; Gerdes, Marsha ; Hurt, Hallam ; D'Angio, Carl T. ; Phelps, Dale L. ; Guillet, Ronnie ; Myers, Gary J. ; Reubens, Linda J. ; Burnell, Erica ; Hust, Diane ; Johnson, Julie Babish ; Hunn, Julianne ; Jensen, Rosemary L. ; Kushner, Emily ; Maffett, Deanna ; Merzbach, Joan ; Wadkins, Holly I.M. ; Yost, Kelley ; Zwetsch, Lauren ; Lakshminrusimha, Satyanarayana ; Reynolds, Anne Marie ; Osman, Farooq ; Williams, Ashley ; Wynn, Karen ; Kennedy, Kathleen A. ; Tyson, Jon E. ; McDavid, Georgia E. ; Alaniz, Nora I. ; Burson, Katrina ; Evans, Patricia W. ; Green, Charles ; Harris, Beverly Foley ; Jiminez, Margarita ; Lis, Anna E. ; Martin, Sarah ; Morris, Brenda H. ; Poundstone, M. Layne ; Robichaux, Peggy ; Siddiki, Saba ; Simmons, Maegan C. ; Pierce Tate, Patti L. ; Wright, Sharon L. ; Brion, Luc P. ; Heyne, Roy J. ; Salhab, Walid A. ; Rosenfeld, Charles R. ; Vasil, Diana M. ; Adams, Sally S. ; Chen, Lijun ; Guzman, Alicia ; Hensley, Gaynelle ; Heyne, Elizabeth T. ; Leps, Melissa H. ; Madden, Linda A. ; Miller, Nancy A. ; Morgan, Janet S. ; Torres, Lizette E. ; Boatman, Catherine Twell ; Faix, Roger G. ; Yoder, Bradley A. ; Bodnar, Anna ; Osborne, Karen A. ; Baker, Shawna ; Bird, Karie ; Burnett, Jill ; Cole, Laura ; Jensen, Jennifer J. ; Spencer, Cynthia ; Steffen, Michael ; Weaver-Lewis, Kimberlee ; Winter, Sarah ; Zanetti, Karen ; O'Shea, T. Michael ; Dillard, Robert G. ; Washburn, Lisa K. ; Jackson, Barbara G. ; Peters, Nancy ; Chiu, Korinne ; Allred, Deborah Evans ; Goldstein, Donald J. ; Halfond, Raquel ; Peterson, Carroll ; Waldrep, Ellen L. ; Welch, Cherrie D. ; Morris, Melissa Whalen ; Hounshell, Gail Wiley ; Barks, John ; Bara, Rebecca ; Argento, Angela ; Goldston, Laura A. ; Johnson, Mary ; Christensen, Mary ; Wiggins, Stephanie ; Ehrenkranz, Richard A. ; Jacobs, Harris ; Butler, Christine G. ; Cervone, Patricia ; Greisman, Sheila ; Konstantino, Monica ; Poulsen, Joann ; Taft, Janet ; Williams, Joanne ; Romano, Elaine. / Neurodevelopmental and behavioral outcomes in extremely premature neonates with ventriculomegaly in the absence of periventricular-intraventricular hemorrhage. In: JAMA Pediatrics. 2018 ; Vol. 172, No. 1. pp. 32-42.
@article{b773934f178f4e5991eb38fecfe7dfe5,
title = "Neurodevelopmental and behavioral outcomes in extremely premature neonates with ventriculomegaly in the absence of periventricular-intraventricular hemorrhage",
abstract = "IMPORTANCE Studies of cranial ultrasonography and early childhood outcomes among cohorts of extremely preterm neonates have linked periventricular-intraventricular hemorrhage and cystic periventricular leukomalacia with adverse neurodevelopmental outcomes. However, the association between nonhemorrhagic ventriculomegaly and neurodevelopmental and behavioral outcomes is not fully understood. OBJECTIVE To characterize the outcomes of extremely preterm neonates younger than 27 weeks' gestational age who experienced nonhemorrhagic ventriculomegaly that was detected prior to 36 weeks' postmenstrual age. DESIGN, SETTING, AND PARTICIPANTS This longitudinal observational studywas conducted at 16 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants born prior to 27 weeks' gestational age in any network facility between July 1, 2006, and June 30, 2011, were included if they had a cranial ultrasonogram performed prior to 36 weeks' postmenstrual age. Comparisons were made between those with ventriculomegaly and those with normal cranial sonograms. Data analysis was completed from August 2013 to August 2017. MAIN OUTCOMES AND MEASURES The main outcomewas neurodevelopmental impairment, defined as a Bayley Scales of Infant and Toddler Development III cognitive score less than 70, moderate/severe cerebral palsy, a Gross Motor Function Classification System score of level 2 or more, vision impairment, or hearing impairment. Secondary outcomes included Bayley Scales of Infant and Toddler Development III subscores, components of neurodevelopmental impairment, behavioral outcomes, and death/neurodevelopmental impairment. Logistic regression was used to evaluate the association of ventriculomegaly with adverse outcomes while controlling for potentially confounding variables and center differences as a random effect. Linear regression was used similarly for continuous outcomes. RESULTS Of4193neonateswithultrasonographydata,300hadnonhemorrhagicventriculomegaly (7{\%}); 3045 had normal cranial ultrasonograms (73{\%}), 775 had periventricular-intraventricular hemorrhage (18.5{\%}), and 73 had cystic periventricular leukomalacia (1.7{\%}). Outcomeswere available for3008of3345neonateswithventriculomegaly ornormalscans(90{\%}).Comparedwith normal cranial ultrasonograms, ventriculomegalywas associated with lower gestational age, male sex, and bronchopulmonary dysplasia, late-onset sepsis, meningitis, necrotizing enterocolitis, and stage 3 retinopathy of prematurity. After adjustment, neonates with ventriculomegaly had higher odds of neurodevelopmental impairment (odds ratio [OR], 3.07; 95{\%}CI, 2.13-4.43), cognitive impairment (OR, 3.23; 95{\%}CI, 2.09-4.99), moderate/severe cerebral palsy (OR, 3.68; 95{\%}CI, 2.08-6.51),death/neurodevelopmentalimpairment(OR,2.17;95{\%}CI,1.62-2.91),butnotdeathalone (OR, 1.09; 95{\%}CI,0.76-1.57). Behavioral outcomes did not differ. CONCLUSIONS AND RELEVANCE Nonhemorrhagic ventriculomegaly is associated with increased odds of neurodevelopmental impairment among extremely preterm neonates.",
author = "Athina Pappas and Ira Adams-Chapman and Seetha Shankaran and McDonald, {Scott A.} and Stoll, {Barbara J.} and Laptook, {Abbot R.} and Carlo, {Waldemar A.} and {Van Meurs}, {Krisa P.} and Hintz, {Susan R.} and Carlson, {Martha D.} and Brumbaugh, {Jane E.} and Walsh, {Michele C.} and Wyckoff, {Myra H.} and Abhik Das and Higgins, {Rosemary D.} and Caplan, {Michael S.} and Polin, {Richard A.} and Martin Keszler and William Oh and Vohr, {Betty R.} and Hensman, {Angelita M.} and Basso, {Kristin M.} and Barbara Alksninis and Robert Burke and Melinda Caskey and Andrea Halbrook and Katharine Johnson and Keszler, {Mary Lenore} and Leach, {Theresa M.} and Stephens, {Bonnie E.} and Suzy Ventura and Watson, {Victoria E.} and Fanaroff, {Avroy A.} and Hibbs, {Anna Marie} and Wilson-Costello, {Deanne E.} and Newman, {Nancy S.} and Payne, {Allison F.} and Siner, {Bonnie S.} and Monika Bhola and Gulgun Yalcinkaya and Friedman, {Harriet G.} and Truog, {William E.} and Pallotto, {Eugenia K.} and Kilbride, {Howard W.} and Cheri Gauldin and Anne Holmes and Kathy Johnson and Kurt Schibler and Donovan, {Edward F.} and Cathy Grisby and Barbara Alexander and Kate Bridges and Fischer, {Estelle E.} and Gratton, {Teresa L.} and Mincey, {Holly L.} and Greg Muthig and Jody Hessling and Jackson, {Lenora D.} and Kristin Kirker and Kimberly Yolton and Goldberg, {Ronald N.} and Cotten, {C. Michael} and Goldstein, {Ricki F.} and Gustafson, {Kathryn E.} and Joanne Finkle and Ashley, {Patricia L.} and Malcolm, {William F.} and Auten, {Kathy J.} and Fisher, {Kimberley A.} and Foy, {Katherine A.} and Sandra Grimes and Lohmeyer, {Melody B.} and Laughon, {Matthew M.} and Bose, {Carl L.} and Janice Bernhardt and Gennie Bose and Wereszczak, {Janice K.} and Carlton, {David P.} and Hale, {Ellen C.} and Loggins, {Yvonne C.} and LaRossa, {Maureen Mulligan} and Carter, {Sheena L.} and Archer, {Stephanie Wilson} and Sokol, {Gregory M.} and Poindexter, {Brenda B.} and Dusick, {Anna M.} and Papile, {Lu Ann} and Herron, {Dianne E.} and Miller, {Lucy C.} and Carolyn Lytle and Cook, {Ann B.} and Minnich, {Heike M.} and Hines, {Abbey C.} and Wilson, {Leslie Dawn} and Faithe Hamer and S{\'a}nchez, {Pablo J.} and Nelin, {Leif D.} and Jadcherla, {Sudarshan R.} and Yeates, {Keith Owen} and Patricia Luzader and Fortney, {Christine A.} and Besner, {Gail E.} and Parikh, {Nehal A.} and Dennis Wallace and Poole, {W. Kenneth} and Auman, {Jeanette O.Donnell} and Crawford, {Margaret M.} and Gantz, {Marie G.} and Newman, {Jamie E.} and {Petrie Huitema}, {Carolyn M.} and Zaterka-Baxter, {Kristin M.} and Stevenson, {David K.} and Ball, {M. Bethany} and Adams, {Marian M.} and Barbara Bentley and Elizabeth Bruno and DeAnda, {Maria Elena} and DeBattista, {Anne M.} and Huffman, {Lynne C.} and Kohn, {Jean G.} and Krueger, {Casey E.} and Palmquist, {Andrew W.} and Proud, {Melinda S.} and Brian Tang and Weiss, {Hali E.} and Frantz, {Ivan D.} and Fiascone, {John M.} and McGowan, {Elisabeth C.} and MacKinnon, {Brenda L.} and Brussa, {Ana K.} and Anne Furey and Ellen Nylen and Sibley, {Cecelia E.} and Namasivayam Ambalavanan and Myriam Peralta-Carcelen and Collins, {Monica V.} and Cosby, {Shirley S.} and Phillips, {Vivien A.} and Biasini, {Fred J.} and Kristy Domnanovich and Johnston, {Kristen C.} and Carin Kiser and Sara Kryzwanski and Nelson, {Kathleen G.} and Patterson, {Cryshelle S.} and Rector, {Richard V.} and Leslie Rodrigues and Sarah Ryan and Smith, {Leigh Ann} and Soong, {Amanda D.} and Sally Whitley and Uday Devaskar and Meena Garg and Purdy, {Isabell B.} and Teresa Chanlaw and Rachel Geller and Finer, {Neil N.} and David Kaegi and Rasmussen, {Maynard R.} and Vaucher, {Yvonne E.} and Kathy Arnell and Clarence Demetrio and Fuller, {Martha G.} and Chris Henderson and Wade Rich and Radmila West and Bell, {Edward F.} and Ellsbury, {Dan L.} and Widness, {John A.} and Colaizy, {Tarah T.} and Acarregui, {Michael J.} and Johnson, {Karen J.} and Campbell, {Donia B.} and Eastman, {Diane L.} and Walker, {Jacky R.} and Shahnaz Duara and Bauer, {Charles R.} and Ruth Everett-Thomas and Sylvia Fajardo-Hiriart and Arielle Rigaud and Maria Calejo and {Frade Eguaras}, {Silvia M.} and Berkowits, {Michelle Harwood} and Andrea Garcia and Helina Pierre and Alexandra Stoerger and Watterberg, {Kristi L.} and Ohls, {Robin K.} and Duncan, {Andrea H.} and Fuller, {Janell F.} and Lacy, {Conra Backstrom} and Sandra Brown and Carol Hartenberger and Lowe, {Jean R.} and Montman, {Rebecca A.} and Barbara Schmidt and Haresh Kirpalani and DeMauro, {Sara B.} and Chaudhary, {Aasma S.} and Soraya Abbasi and Toni Mancini and Cucinotta, {Dara M.} and Bernbaum, {Judy C.} and Marsha Gerdes and Hallam Hurt and D'Angio, {Carl T.} and Phelps, {Dale L.} and Ronnie Guillet and Myers, {Gary J.} and Reubens, {Linda J.} and Erica Burnell and Diane Hust and Johnson, {Julie Babish} and Julianne Hunn and Jensen, {Rosemary L.} and Emily Kushner and Deanna Maffett and Joan Merzbach and Wadkins, {Holly I.M.} and Kelley Yost and Lauren Zwetsch and Satyanarayana Lakshminrusimha and Reynolds, {Anne Marie} and Farooq Osman and Ashley Williams and Karen Wynn and Kennedy, {Kathleen A.} and Tyson, {Jon E.} and McDavid, {Georgia E.} and Alaniz, {Nora I.} and Katrina Burson and Evans, {Patricia W.} and Charles Green and Harris, {Beverly Foley} and Margarita Jiminez and Lis, {Anna E.} and Sarah Martin and Morris, {Brenda H.} and Poundstone, {M. Layne} and Peggy Robichaux and Saba Siddiki and Simmons, {Maegan C.} and {Pierce Tate}, {Patti L.} and Wright, {Sharon L.} and Brion, {Luc P.} and Heyne, {Roy J.} and Salhab, {Walid A.} and Rosenfeld, {Charles R.} and Vasil, {Diana M.} and Adams, {Sally S.} and Lijun Chen and Alicia Guzman and Gaynelle Hensley and Heyne, {Elizabeth T.} and Leps, {Melissa H.} and Madden, {Linda A.} and Miller, {Nancy A.} and Morgan, {Janet S.} and Torres, {Lizette E.} and Boatman, {Catherine Twell} and Faix, {Roger G.} and Yoder, {Bradley A.} and Anna Bodnar and Osborne, {Karen A.} and Shawna Baker and Karie Bird and Jill Burnett and Laura Cole and Jensen, {Jennifer J.} and Cynthia Spencer and Michael Steffen and Kimberlee Weaver-Lewis and Sarah Winter and Karen Zanetti and O'Shea, {T. Michael} and Dillard, {Robert G.} and Washburn, {Lisa K.} and Jackson, {Barbara G.} and Nancy Peters and Korinne Chiu and Allred, {Deborah Evans} and Goldstein, {Donald J.} and Raquel Halfond and Carroll Peterson and Waldrep, {Ellen L.} and Welch, {Cherrie D.} and Morris, {Melissa Whalen} and Hounshell, {Gail Wiley} and John Barks and Rebecca Bara and Angela Argento and Goldston, {Laura A.} and Mary Johnson and Mary Christensen and Stephanie Wiggins and Ehrenkranz, {Richard A.} and Harris Jacobs and Butler, {Christine G.} and Patricia Cervone and Sheila Greisman and Monica Konstantino and Joann Poulsen and Janet Taft and Joanne Williams and Elaine Romano",
year = "2018",
month = "1",
day = "1",
doi = "10.1001/jamapediatrics.2017.3545",
language = "English (US)",
volume = "172",
pages = "32--42",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association",
number = "1",

}

TY - JOUR

T1 - Neurodevelopmental and behavioral outcomes in extremely premature neonates with ventriculomegaly in the absence of periventricular-intraventricular hemorrhage

AU - Pappas, Athina

AU - Adams-Chapman, Ira

AU - Shankaran, Seetha

AU - McDonald, Scott A.

AU - Stoll, Barbara J.

AU - Laptook, Abbot R.

AU - Carlo, Waldemar A.

AU - Van Meurs, Krisa P.

AU - Hintz, Susan R.

AU - Carlson, Martha D.

AU - Brumbaugh, Jane E.

AU - Walsh, Michele C.

AU - Wyckoff, Myra H.

AU - Das, Abhik

AU - Higgins, Rosemary D.

AU - Caplan, Michael S.

AU - Polin, Richard A.

AU - Keszler, Martin

AU - Oh, William

AU - Vohr, Betty R.

AU - Hensman, Angelita M.

AU - Basso, Kristin M.

AU - Alksninis, Barbara

AU - Burke, Robert

AU - Caskey, Melinda

AU - Halbrook, Andrea

AU - Johnson, Katharine

AU - Keszler, Mary Lenore

AU - Leach, Theresa M.

AU - Stephens, Bonnie E.

AU - Ventura, Suzy

AU - Watson, Victoria E.

AU - Fanaroff, Avroy A.

AU - Hibbs, Anna Marie

AU - Wilson-Costello, Deanne E.

AU - Newman, Nancy S.

AU - Payne, Allison F.

AU - Siner, Bonnie S.

AU - Bhola, Monika

AU - Yalcinkaya, Gulgun

AU - Friedman, Harriet G.

AU - Truog, William E.

AU - Pallotto, Eugenia K.

AU - Kilbride, Howard W.

AU - Gauldin, Cheri

AU - Holmes, Anne

AU - Johnson, Kathy

AU - Schibler, Kurt

AU - Donovan, Edward F.

AU - Grisby, Cathy

AU - Alexander, Barbara

AU - Bridges, Kate

AU - Fischer, Estelle E.

AU - Gratton, Teresa L.

AU - Mincey, Holly L.

AU - Muthig, Greg

AU - Hessling, Jody

AU - Jackson, Lenora D.

AU - Kirker, Kristin

AU - Yolton, Kimberly

AU - Goldberg, Ronald N.

AU - Cotten, C. Michael

AU - Goldstein, Ricki F.

AU - Gustafson, Kathryn E.

AU - Finkle, Joanne

AU - Ashley, Patricia L.

AU - Malcolm, William F.

AU - Auten, Kathy J.

AU - Fisher, Kimberley A.

AU - Foy, Katherine A.

AU - Grimes, Sandra

AU - Lohmeyer, Melody B.

AU - Laughon, Matthew M.

AU - Bose, Carl L.

AU - Bernhardt, Janice

AU - Bose, Gennie

AU - Wereszczak, Janice K.

AU - Carlton, David P.

AU - Hale, Ellen C.

AU - Loggins, Yvonne C.

AU - LaRossa, Maureen Mulligan

AU - Carter, Sheena L.

AU - Archer, Stephanie Wilson

AU - Sokol, Gregory M.

AU - Poindexter, Brenda B.

AU - Dusick, Anna M.

AU - Papile, Lu Ann

AU - Herron, Dianne E.

AU - Miller, Lucy C.

AU - Lytle, Carolyn

AU - Cook, Ann B.

AU - Minnich, Heike M.

AU - Hines, Abbey C.

AU - Wilson, Leslie Dawn

AU - Hamer, Faithe

AU - Sánchez, Pablo J.

AU - Nelin, Leif D.

AU - Jadcherla, Sudarshan R.

AU - Yeates, Keith Owen

AU - Luzader, Patricia

AU - Fortney, Christine A.

AU - Besner, Gail E.

AU - Parikh, Nehal A.

AU - Wallace, Dennis

AU - Poole, W. Kenneth

AU - Auman, Jeanette O.Donnell

AU - Crawford, Margaret M.

AU - Gantz, Marie G.

AU - Newman, Jamie E.

AU - Petrie Huitema, Carolyn M.

AU - Zaterka-Baxter, Kristin M.

AU - Stevenson, David K.

AU - Ball, M. Bethany

AU - Adams, Marian M.

AU - Bentley, Barbara

AU - Bruno, Elizabeth

AU - DeAnda, Maria Elena

AU - DeBattista, Anne M.

AU - Huffman, Lynne C.

AU - Kohn, Jean G.

AU - Krueger, Casey E.

AU - Palmquist, Andrew W.

AU - Proud, Melinda S.

AU - Tang, Brian

AU - Weiss, Hali E.

AU - Frantz, Ivan D.

AU - Fiascone, John M.

AU - McGowan, Elisabeth C.

AU - MacKinnon, Brenda L.

AU - Brussa, Ana K.

AU - Furey, Anne

AU - Nylen, Ellen

AU - Sibley, Cecelia E.

AU - Ambalavanan, Namasivayam

AU - Peralta-Carcelen, Myriam

AU - Collins, Monica V.

AU - Cosby, Shirley S.

AU - Phillips, Vivien A.

AU - Biasini, Fred J.

AU - Domnanovich, Kristy

AU - Johnston, Kristen C.

AU - Kiser, Carin

AU - Kryzwanski, Sara

AU - Nelson, Kathleen G.

AU - Patterson, Cryshelle S.

AU - Rector, Richard V.

AU - Rodrigues, Leslie

AU - Ryan, Sarah

AU - Smith, Leigh Ann

AU - Soong, Amanda D.

AU - Whitley, Sally

AU - Devaskar, Uday

AU - Garg, Meena

AU - Purdy, Isabell B.

AU - Chanlaw, Teresa

AU - Geller, Rachel

AU - Finer, Neil N.

AU - Kaegi, David

AU - Rasmussen, Maynard R.

AU - Vaucher, Yvonne E.

AU - Arnell, Kathy

AU - Demetrio, Clarence

AU - Fuller, Martha G.

AU - Henderson, Chris

AU - Rich, Wade

AU - West, Radmila

AU - Bell, Edward F.

AU - Ellsbury, Dan L.

AU - Widness, John A.

AU - Colaizy, Tarah T.

AU - Acarregui, Michael J.

AU - Johnson, Karen J.

AU - Campbell, Donia B.

AU - Eastman, Diane L.

AU - Walker, Jacky R.

AU - Duara, Shahnaz

AU - Bauer, Charles R.

AU - Everett-Thomas, Ruth

AU - Fajardo-Hiriart, Sylvia

AU - Rigaud, Arielle

AU - Calejo, Maria

AU - Frade Eguaras, Silvia M.

AU - Berkowits, Michelle Harwood

AU - Garcia, Andrea

AU - Pierre, Helina

AU - Stoerger, Alexandra

AU - Watterberg, Kristi L.

AU - Ohls, Robin K.

AU - Duncan, Andrea H.

AU - Fuller, Janell F.

AU - Lacy, Conra Backstrom

AU - Brown, Sandra

AU - Hartenberger, Carol

AU - Lowe, Jean R.

AU - Montman, Rebecca A.

AU - Schmidt, Barbara

AU - Kirpalani, Haresh

AU - DeMauro, Sara B.

AU - Chaudhary, Aasma S.

AU - Abbasi, Soraya

AU - Mancini, Toni

AU - Cucinotta, Dara M.

AU - Bernbaum, Judy C.

AU - Gerdes, Marsha

AU - Hurt, Hallam

AU - D'Angio, Carl T.

AU - Phelps, Dale L.

AU - Guillet, Ronnie

AU - Myers, Gary J.

AU - Reubens, Linda J.

AU - Burnell, Erica

AU - Hust, Diane

AU - Johnson, Julie Babish

AU - Hunn, Julianne

AU - Jensen, Rosemary L.

AU - Kushner, Emily

AU - Maffett, Deanna

AU - Merzbach, Joan

AU - Wadkins, Holly I.M.

AU - Yost, Kelley

AU - Zwetsch, Lauren

AU - Lakshminrusimha, Satyanarayana

AU - Reynolds, Anne Marie

AU - Osman, Farooq

AU - Williams, Ashley

AU - Wynn, Karen

AU - Kennedy, Kathleen A.

AU - Tyson, Jon E.

AU - McDavid, Georgia E.

AU - Alaniz, Nora I.

AU - Burson, Katrina

AU - Evans, Patricia W.

AU - Green, Charles

AU - Harris, Beverly Foley

AU - Jiminez, Margarita

AU - Lis, Anna E.

AU - Martin, Sarah

AU - Morris, Brenda H.

AU - Poundstone, M. Layne

AU - Robichaux, Peggy

AU - Siddiki, Saba

AU - Simmons, Maegan C.

AU - Pierce Tate, Patti L.

AU - Wright, Sharon L.

AU - Brion, Luc P.

AU - Heyne, Roy J.

AU - Salhab, Walid A.

AU - Rosenfeld, Charles R.

AU - Vasil, Diana M.

AU - Adams, Sally S.

AU - Chen, Lijun

AU - Guzman, Alicia

AU - Hensley, Gaynelle

AU - Heyne, Elizabeth T.

AU - Leps, Melissa H.

AU - Madden, Linda A.

AU - Miller, Nancy A.

AU - Morgan, Janet S.

AU - Torres, Lizette E.

AU - Boatman, Catherine Twell

AU - Faix, Roger G.

AU - Yoder, Bradley A.

AU - Bodnar, Anna

AU - Osborne, Karen A.

AU - Baker, Shawna

AU - Bird, Karie

AU - Burnett, Jill

AU - Cole, Laura

AU - Jensen, Jennifer J.

AU - Spencer, Cynthia

AU - Steffen, Michael

AU - Weaver-Lewis, Kimberlee

AU - Winter, Sarah

AU - Zanetti, Karen

AU - O'Shea, T. Michael

AU - Dillard, Robert G.

AU - Washburn, Lisa K.

AU - Jackson, Barbara G.

AU - Peters, Nancy

AU - Chiu, Korinne

AU - Allred, Deborah Evans

AU - Goldstein, Donald J.

AU - Halfond, Raquel

AU - Peterson, Carroll

AU - Waldrep, Ellen L.

AU - Welch, Cherrie D.

AU - Morris, Melissa Whalen

AU - Hounshell, Gail Wiley

AU - Barks, John

AU - Bara, Rebecca

AU - Argento, Angela

AU - Goldston, Laura A.

AU - Johnson, Mary

AU - Christensen, Mary

AU - Wiggins, Stephanie

AU - Ehrenkranz, Richard A.

AU - Jacobs, Harris

AU - Butler, Christine G.

AU - Cervone, Patricia

AU - Greisman, Sheila

AU - Konstantino, Monica

AU - Poulsen, Joann

AU - Taft, Janet

AU - Williams, Joanne

AU - Romano, Elaine

PY - 2018/1/1

Y1 - 2018/1/1

N2 - IMPORTANCE Studies of cranial ultrasonography and early childhood outcomes among cohorts of extremely preterm neonates have linked periventricular-intraventricular hemorrhage and cystic periventricular leukomalacia with adverse neurodevelopmental outcomes. However, the association between nonhemorrhagic ventriculomegaly and neurodevelopmental and behavioral outcomes is not fully understood. OBJECTIVE To characterize the outcomes of extremely preterm neonates younger than 27 weeks' gestational age who experienced nonhemorrhagic ventriculomegaly that was detected prior to 36 weeks' postmenstrual age. DESIGN, SETTING, AND PARTICIPANTS This longitudinal observational studywas conducted at 16 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants born prior to 27 weeks' gestational age in any network facility between July 1, 2006, and June 30, 2011, were included if they had a cranial ultrasonogram performed prior to 36 weeks' postmenstrual age. Comparisons were made between those with ventriculomegaly and those with normal cranial sonograms. Data analysis was completed from August 2013 to August 2017. MAIN OUTCOMES AND MEASURES The main outcomewas neurodevelopmental impairment, defined as a Bayley Scales of Infant and Toddler Development III cognitive score less than 70, moderate/severe cerebral palsy, a Gross Motor Function Classification System score of level 2 or more, vision impairment, or hearing impairment. Secondary outcomes included Bayley Scales of Infant and Toddler Development III subscores, components of neurodevelopmental impairment, behavioral outcomes, and death/neurodevelopmental impairment. Logistic regression was used to evaluate the association of ventriculomegaly with adverse outcomes while controlling for potentially confounding variables and center differences as a random effect. Linear regression was used similarly for continuous outcomes. RESULTS Of4193neonateswithultrasonographydata,300hadnonhemorrhagicventriculomegaly (7%); 3045 had normal cranial ultrasonograms (73%), 775 had periventricular-intraventricular hemorrhage (18.5%), and 73 had cystic periventricular leukomalacia (1.7%). Outcomeswere available for3008of3345neonateswithventriculomegaly ornormalscans(90%).Comparedwith normal cranial ultrasonograms, ventriculomegalywas associated with lower gestational age, male sex, and bronchopulmonary dysplasia, late-onset sepsis, meningitis, necrotizing enterocolitis, and stage 3 retinopathy of prematurity. After adjustment, neonates with ventriculomegaly had higher odds of neurodevelopmental impairment (odds ratio [OR], 3.07; 95%CI, 2.13-4.43), cognitive impairment (OR, 3.23; 95%CI, 2.09-4.99), moderate/severe cerebral palsy (OR, 3.68; 95%CI, 2.08-6.51),death/neurodevelopmentalimpairment(OR,2.17;95%CI,1.62-2.91),butnotdeathalone (OR, 1.09; 95%CI,0.76-1.57). Behavioral outcomes did not differ. CONCLUSIONS AND RELEVANCE Nonhemorrhagic ventriculomegaly is associated with increased odds of neurodevelopmental impairment among extremely preterm neonates.

AB - IMPORTANCE Studies of cranial ultrasonography and early childhood outcomes among cohorts of extremely preterm neonates have linked periventricular-intraventricular hemorrhage and cystic periventricular leukomalacia with adverse neurodevelopmental outcomes. However, the association between nonhemorrhagic ventriculomegaly and neurodevelopmental and behavioral outcomes is not fully understood. OBJECTIVE To characterize the outcomes of extremely preterm neonates younger than 27 weeks' gestational age who experienced nonhemorrhagic ventriculomegaly that was detected prior to 36 weeks' postmenstrual age. DESIGN, SETTING, AND PARTICIPANTS This longitudinal observational studywas conducted at 16 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants born prior to 27 weeks' gestational age in any network facility between July 1, 2006, and June 30, 2011, were included if they had a cranial ultrasonogram performed prior to 36 weeks' postmenstrual age. Comparisons were made between those with ventriculomegaly and those with normal cranial sonograms. Data analysis was completed from August 2013 to August 2017. MAIN OUTCOMES AND MEASURES The main outcomewas neurodevelopmental impairment, defined as a Bayley Scales of Infant and Toddler Development III cognitive score less than 70, moderate/severe cerebral palsy, a Gross Motor Function Classification System score of level 2 or more, vision impairment, or hearing impairment. Secondary outcomes included Bayley Scales of Infant and Toddler Development III subscores, components of neurodevelopmental impairment, behavioral outcomes, and death/neurodevelopmental impairment. Logistic regression was used to evaluate the association of ventriculomegaly with adverse outcomes while controlling for potentially confounding variables and center differences as a random effect. Linear regression was used similarly for continuous outcomes. RESULTS Of4193neonateswithultrasonographydata,300hadnonhemorrhagicventriculomegaly (7%); 3045 had normal cranial ultrasonograms (73%), 775 had periventricular-intraventricular hemorrhage (18.5%), and 73 had cystic periventricular leukomalacia (1.7%). Outcomeswere available for3008of3345neonateswithventriculomegaly ornormalscans(90%).Comparedwith normal cranial ultrasonograms, ventriculomegalywas associated with lower gestational age, male sex, and bronchopulmonary dysplasia, late-onset sepsis, meningitis, necrotizing enterocolitis, and stage 3 retinopathy of prematurity. After adjustment, neonates with ventriculomegaly had higher odds of neurodevelopmental impairment (odds ratio [OR], 3.07; 95%CI, 2.13-4.43), cognitive impairment (OR, 3.23; 95%CI, 2.09-4.99), moderate/severe cerebral palsy (OR, 3.68; 95%CI, 2.08-6.51),death/neurodevelopmentalimpairment(OR,2.17;95%CI,1.62-2.91),butnotdeathalone (OR, 1.09; 95%CI,0.76-1.57). Behavioral outcomes did not differ. CONCLUSIONS AND RELEVANCE Nonhemorrhagic ventriculomegaly is associated with increased odds of neurodevelopmental impairment among extremely preterm neonates.

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U2 - 10.1001/jamapediatrics.2017.3545

DO - 10.1001/jamapediatrics.2017.3545

M3 - Article

VL - 172

SP - 32

EP - 42

JO - JAMA Pediatrics

JF - JAMA Pediatrics

SN - 2168-6203

IS - 1

ER -