Neurodegenerative disease transmission and transgenesis in mice

Brittany Dugger, Daniel P. Perl, George A. Carlson

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Although the discovery of the prion protein (PrP) resulted fromits co-purification with scrapie infectivity in Syrian hamsters, work with genetically defined and genetically modified mice proved crucial for understanding the fundamental processes involved not only in prion diseases caused by PrP misfolding, aggregation, and spread but also in other, much more common, neurodegenerative brain diseases. In this review, we focus on methodological and conceptual approaches used to study scrapie and related PrP misfolding diseases in mice and how these approaches have advanced our understanding of related disorders including Alzheimer’s and Parkinson’s disease.

Original languageEnglish (US)
Article numbera023549
JournalCold Spring Harbor perspectives in biology
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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