Neurodegenerative disease transmission and transgenesis in mice

Brittany Dugger, Daniel P. Perl, George A. Carlson

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Although the discovery of the prion protein (PrP) resulted fromits co-purification with scrapie infectivity in Syrian hamsters, work with genetically defined and genetically modified mice proved crucial for understanding the fundamental processes involved not only in prion diseases caused by PrP misfolding, aggregation, and spread but also in other, much more common, neurodegenerative brain diseases. In this review, we focus on methodological and conceptual approaches used to study scrapie and related PrP misfolding diseases in mice and how these approaches have advanced our understanding of related disorders including Alzheimer’s and Parkinson’s disease.

Original languageEnglish (US)
Article numbera023549
JournalCold Spring Harbor perspectives in biology
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Neurodegenerative diseases
Scrapie
Gene Transfer Techniques
Prion Diseases
Neurodegenerative Diseases
Proteostasis Deficiencies
Mesocricetus
Brain Diseases
Parkinson Disease
Alzheimer Disease
Prions
Purification
Brain
Agglomeration
Prion Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Neurodegenerative disease transmission and transgenesis in mice. / Dugger, Brittany; Perl, Daniel P.; Carlson, George A.

In: Cold Spring Harbor perspectives in biology, Vol. 9, No. 11, a023549, 01.11.2017.

Research output: Contribution to journalReview article

@article{4ba74c1fcaab48b89ea7164ca2ec13a2,
title = "Neurodegenerative disease transmission and transgenesis in mice",
abstract = "Although the discovery of the prion protein (PrP) resulted fromits co-purification with scrapie infectivity in Syrian hamsters, work with genetically defined and genetically modified mice proved crucial for understanding the fundamental processes involved not only in prion diseases caused by PrP misfolding, aggregation, and spread but also in other, much more common, neurodegenerative brain diseases. In this review, we focus on methodological and conceptual approaches used to study scrapie and related PrP misfolding diseases in mice and how these approaches have advanced our understanding of related disorders including Alzheimer’s and Parkinson’s disease.",
author = "Brittany Dugger and Perl, {Daniel P.} and Carlson, {George A.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1101/cshperspect.a023549",
language = "English (US)",
volume = "9",
journal = "Cold Spring Harbor perspectives in biology",
issn = "1943-0264",
publisher = "Cold Spring Harbor Laboratory Press",
number = "11",

}

TY - JOUR

T1 - Neurodegenerative disease transmission and transgenesis in mice

AU - Dugger, Brittany

AU - Perl, Daniel P.

AU - Carlson, George A.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Although the discovery of the prion protein (PrP) resulted fromits co-purification with scrapie infectivity in Syrian hamsters, work with genetically defined and genetically modified mice proved crucial for understanding the fundamental processes involved not only in prion diseases caused by PrP misfolding, aggregation, and spread but also in other, much more common, neurodegenerative brain diseases. In this review, we focus on methodological and conceptual approaches used to study scrapie and related PrP misfolding diseases in mice and how these approaches have advanced our understanding of related disorders including Alzheimer’s and Parkinson’s disease.

AB - Although the discovery of the prion protein (PrP) resulted fromits co-purification with scrapie infectivity in Syrian hamsters, work with genetically defined and genetically modified mice proved crucial for understanding the fundamental processes involved not only in prion diseases caused by PrP misfolding, aggregation, and spread but also in other, much more common, neurodegenerative brain diseases. In this review, we focus on methodological and conceptual approaches used to study scrapie and related PrP misfolding diseases in mice and how these approaches have advanced our understanding of related disorders including Alzheimer’s and Parkinson’s disease.

UR - http://www.scopus.com/inward/record.url?scp=85030241301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030241301&partnerID=8YFLogxK

U2 - 10.1101/cshperspect.a023549

DO - 10.1101/cshperspect.a023549

M3 - Review article

C2 - 28193724

AN - SCOPUS:85030241301

VL - 9

JO - Cold Spring Harbor perspectives in biology

JF - Cold Spring Harbor perspectives in biology

SN - 1943-0264

IS - 11

M1 - a023549

ER -