Abstract
Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-45 |
| Number of pages | 11 |
| Journal | Brain and Language |
| Volume | 194 |
| DOIs | |
| State | Published - Jul 1 2019 |
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Keywords
- Cortical thickness
- Length
- Phrase repetition
- Primary progressive aphasia
- Semantics
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Language and Linguistics
- Linguistics and Language
- Cognitive Neuroscience
- Speech and Hearing
Cite this
Neurocognitive basis of repetition deficits in primary progressive aphasia. / Lukic, Sladjana; Mandelli, Maria Luisa; Welch, Ariane; Jordan, Kesshi; Shwe, Wendy; Neuhaus, John; Miller, Zachary; Hubbard, H. Isabel; Henry, Maya; Miller, Bruce L.; Dronkers, Nina; Gorno-Tempini, Maria Luisa.
In: Brain and Language, Vol. 194, 01.07.2019, p. 35-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurocognitive basis of repetition deficits in primary progressive aphasia
AU - Lukic, Sladjana
AU - Mandelli, Maria Luisa
AU - Welch, Ariane
AU - Jordan, Kesshi
AU - Shwe, Wendy
AU - Neuhaus, John
AU - Miller, Zachary
AU - Hubbard, H. Isabel
AU - Henry, Maya
AU - Miller, Bruce L.
AU - Dronkers, Nina
AU - Gorno-Tempini, Maria Luisa
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.
AB - Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.
KW - Cortical thickness
KW - Length
KW - Phrase repetition
KW - Primary progressive aphasia
KW - Semantics
UR - http://www.scopus.com/inward/record.url?scp=85064947282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064947282&partnerID=8YFLogxK
U2 - 10.1016/j.bandl.2019.04.003
DO - 10.1016/j.bandl.2019.04.003
M3 - Article
C2 - 31055171
AN - SCOPUS:85064947282
VL - 194
SP - 35
EP - 45
JO - Brain and Language
JF - Brain and Language
SN - 0093-934X
ER -