Neurocognitive basis of repetition deficits in primary progressive aphasia

Sladjana Lukic, Maria Luisa Mandelli, Ariane Welch, Kesshi Jordan, Wendy Shwe, John Neuhaus, Zachary Miller, H. Isabel Hubbard, Maya Henry, Bruce L. Miller, Nina Dronkers, Maria Luisa Gorno-Tempini

Research output: Contribution to journalArticle

Abstract

Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.

Original languageEnglish (US)
Pages (from-to)35-45
Number of pages11
JournalBrain and Language
Volume194
DOIs
StatePublished - Jul 1 2019

Fingerprint

Primary Progressive Aphasia
speech disorder
Semantics
deficit
Short-Term Memory
semantics
Auditory Cortex
Healthy Volunteers
performance

Keywords

  • Cortical thickness
  • Length
  • Phrase repetition
  • Primary progressive aphasia
  • Semantics

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

Cite this

Lukic, S., Mandelli, M. L., Welch, A., Jordan, K., Shwe, W., Neuhaus, J., ... Gorno-Tempini, M. L. (2019). Neurocognitive basis of repetition deficits in primary progressive aphasia. Brain and Language, 194, 35-45. https://doi.org/10.1016/j.bandl.2019.04.003

Neurocognitive basis of repetition deficits in primary progressive aphasia. / Lukic, Sladjana; Mandelli, Maria Luisa; Welch, Ariane; Jordan, Kesshi; Shwe, Wendy; Neuhaus, John; Miller, Zachary; Hubbard, H. Isabel; Henry, Maya; Miller, Bruce L.; Dronkers, Nina; Gorno-Tempini, Maria Luisa.

In: Brain and Language, Vol. 194, 01.07.2019, p. 35-45.

Research output: Contribution to journalArticle

Lukic, S, Mandelli, ML, Welch, A, Jordan, K, Shwe, W, Neuhaus, J, Miller, Z, Hubbard, HI, Henry, M, Miller, BL, Dronkers, N & Gorno-Tempini, ML 2019, 'Neurocognitive basis of repetition deficits in primary progressive aphasia', Brain and Language, vol. 194, pp. 35-45. https://doi.org/10.1016/j.bandl.2019.04.003
Lukic S, Mandelli ML, Welch A, Jordan K, Shwe W, Neuhaus J et al. Neurocognitive basis of repetition deficits in primary progressive aphasia. Brain and Language. 2019 Jul 1;194:35-45. https://doi.org/10.1016/j.bandl.2019.04.003
Lukic, Sladjana ; Mandelli, Maria Luisa ; Welch, Ariane ; Jordan, Kesshi ; Shwe, Wendy ; Neuhaus, John ; Miller, Zachary ; Hubbard, H. Isabel ; Henry, Maya ; Miller, Bruce L. ; Dronkers, Nina ; Gorno-Tempini, Maria Luisa. / Neurocognitive basis of repetition deficits in primary progressive aphasia. In: Brain and Language. 2019 ; Vol. 194. pp. 35-45.
@article{6e5ffd9ee6344f05b8802a68cb0b7f73,
title = "Neurocognitive basis of repetition deficits in primary progressive aphasia",
abstract = "Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89{\%} accuracy.",
keywords = "Cortical thickness, Length, Phrase repetition, Primary progressive aphasia, Semantics",
author = "Sladjana Lukic and Mandelli, {Maria Luisa} and Ariane Welch and Kesshi Jordan and Wendy Shwe and John Neuhaus and Zachary Miller and Hubbard, {H. Isabel} and Maya Henry and Miller, {Bruce L.} and Nina Dronkers and Gorno-Tempini, {Maria Luisa}",
year = "2019",
month = "7",
day = "1",
doi = "10.1016/j.bandl.2019.04.003",
language = "English (US)",
volume = "194",
pages = "35--45",
journal = "Brain and Language",
issn = "0093-934X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Neurocognitive basis of repetition deficits in primary progressive aphasia

AU - Lukic, Sladjana

AU - Mandelli, Maria Luisa

AU - Welch, Ariane

AU - Jordan, Kesshi

AU - Shwe, Wendy

AU - Neuhaus, John

AU - Miller, Zachary

AU - Hubbard, H. Isabel

AU - Henry, Maya

AU - Miller, Bruce L.

AU - Dronkers, Nina

AU - Gorno-Tempini, Maria Luisa

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.

AB - Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.

KW - Cortical thickness

KW - Length

KW - Phrase repetition

KW - Primary progressive aphasia

KW - Semantics

UR - http://www.scopus.com/inward/record.url?scp=85064947282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064947282&partnerID=8YFLogxK

U2 - 10.1016/j.bandl.2019.04.003

DO - 10.1016/j.bandl.2019.04.003

M3 - Article

VL - 194

SP - 35

EP - 45

JO - Brain and Language

JF - Brain and Language

SN - 0093-934X

ER -