Abstract
The satiety syndrome induced by intraperitoneally administered cholecystokinin (CCK) requires an intact visceral sensory feedback system involving the afferent vagus nerve [5, 22, 33] and the nucleus tractus solitarius (NTS) [9, 10]. Since both the vagus and the NTS contain CCK [25,37], the vagal-NTS synapse could conceivably employ CCK as a transmitter. To test this hypothesis, CCK was injected directly into the NTS region in awake rats. CCK at doses of 1 ng, 10 ng, and 100 ng had no effect on food consumption or exploratory behaviors associated with the satiety syndrome. The acetylcholine agonist carbachol, injected directly into the NTS region, effectively mimicked the actions of intraperitoneally administered CCK on feeding and exploration. These data suggest that CCK is not the transmitter at the vagal-NTS site in the visceral sensory pathway projecting to brain regions mediating the reduced feeding and exploration actions of systemic CCK.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 133-137 |
| Number of pages | 5 |
| Journal | Peptides |
| Volume | 6 |
| Issue number | SUPPL. 1 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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Keywords
- Cholecystokinin
- Exploratory behavior
- Feeding behavior
- Nucleus tractus solitarius
- Peptides
- Satiety
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience
Cite this
Neurochemical investigation of the afferent pathway from the vagus nerve to the nucleus tractus solitarius in mediating the "satiety syndrome" induced by systemic cholecystokinin. / Crawley, Jacqueline.
In: Peptides, Vol. 6, No. SUPPL. 1, 1985, p. 133-137.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurochemical investigation of the afferent pathway from the vagus nerve to the nucleus tractus solitarius in mediating the "satiety syndrome" induced by systemic cholecystokinin
AU - Crawley, Jacqueline
PY - 1985
Y1 - 1985
N2 - The satiety syndrome induced by intraperitoneally administered cholecystokinin (CCK) requires an intact visceral sensory feedback system involving the afferent vagus nerve [5, 22, 33] and the nucleus tractus solitarius (NTS) [9, 10]. Since both the vagus and the NTS contain CCK [25,37], the vagal-NTS synapse could conceivably employ CCK as a transmitter. To test this hypothesis, CCK was injected directly into the NTS region in awake rats. CCK at doses of 1 ng, 10 ng, and 100 ng had no effect on food consumption or exploratory behaviors associated with the satiety syndrome. The acetylcholine agonist carbachol, injected directly into the NTS region, effectively mimicked the actions of intraperitoneally administered CCK on feeding and exploration. These data suggest that CCK is not the transmitter at the vagal-NTS site in the visceral sensory pathway projecting to brain regions mediating the reduced feeding and exploration actions of systemic CCK.
AB - The satiety syndrome induced by intraperitoneally administered cholecystokinin (CCK) requires an intact visceral sensory feedback system involving the afferent vagus nerve [5, 22, 33] and the nucleus tractus solitarius (NTS) [9, 10]. Since both the vagus and the NTS contain CCK [25,37], the vagal-NTS synapse could conceivably employ CCK as a transmitter. To test this hypothesis, CCK was injected directly into the NTS region in awake rats. CCK at doses of 1 ng, 10 ng, and 100 ng had no effect on food consumption or exploratory behaviors associated with the satiety syndrome. The acetylcholine agonist carbachol, injected directly into the NTS region, effectively mimicked the actions of intraperitoneally administered CCK on feeding and exploration. These data suggest that CCK is not the transmitter at the vagal-NTS site in the visceral sensory pathway projecting to brain regions mediating the reduced feeding and exploration actions of systemic CCK.
KW - Cholecystokinin
KW - Exploratory behavior
KW - Feeding behavior
KW - Nucleus tractus solitarius
KW - Peptides
KW - Satiety
UR - http://www.scopus.com/inward/record.url?scp=0022380186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022380186&partnerID=8YFLogxK
U2 - 10.1016/0196-9781(85)90022-1
DO - 10.1016/0196-9781(85)90022-1
M3 - Article
VL - 6
SP - 133
EP - 137
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - SUPPL. 1
ER -