Neurochemical investigation of the afferent pathway from the vagus nerve to the nucleus tractus solitarius in mediating the "satiety syndrome" induced by systemic cholecystokinin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The satiety syndrome induced by intraperitoneally administered cholecystokinin (CCK) requires an intact visceral sensory feedback system involving the afferent vagus nerve [5, 22, 33] and the nucleus tractus solitarius (NTS) [9, 10]. Since both the vagus and the NTS contain CCK [25,37], the vagal-NTS synapse could conceivably employ CCK as a transmitter. To test this hypothesis, CCK was injected directly into the NTS region in awake rats. CCK at doses of 1 ng, 10 ng, and 100 ng had no effect on food consumption or exploratory behaviors associated with the satiety syndrome. The acetylcholine agonist carbachol, injected directly into the NTS region, effectively mimicked the actions of intraperitoneally administered CCK on feeding and exploration. These data suggest that CCK is not the transmitter at the vagal-NTS site in the visceral sensory pathway projecting to brain regions mediating the reduced feeding and exploration actions of systemic CCK.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalPeptides
Volume6
Issue numberSUPPL. 1
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Afferent Pathways
Solitary Nucleus
Vagus Nerve
Cholecystokinin
Transmitters
Sensory feedback
Cholinergic Agonists
Sensory Feedback
Exploratory Behavior
Carbachol
Synapses
Rats
Brain
Food

Keywords

  • Cholecystokinin
  • Exploratory behavior
  • Feeding behavior
  • Nucleus tractus solitarius
  • Peptides
  • Satiety

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

@article{b2385dbaa06c484cb1117bb84b8672ae,
title = "Neurochemical investigation of the afferent pathway from the vagus nerve to the nucleus tractus solitarius in mediating the {"}satiety syndrome{"} induced by systemic cholecystokinin",
abstract = "The satiety syndrome induced by intraperitoneally administered cholecystokinin (CCK) requires an intact visceral sensory feedback system involving the afferent vagus nerve [5, 22, 33] and the nucleus tractus solitarius (NTS) [9, 10]. Since both the vagus and the NTS contain CCK [25,37], the vagal-NTS synapse could conceivably employ CCK as a transmitter. To test this hypothesis, CCK was injected directly into the NTS region in awake rats. CCK at doses of 1 ng, 10 ng, and 100 ng had no effect on food consumption or exploratory behaviors associated with the satiety syndrome. The acetylcholine agonist carbachol, injected directly into the NTS region, effectively mimicked the actions of intraperitoneally administered CCK on feeding and exploration. These data suggest that CCK is not the transmitter at the vagal-NTS site in the visceral sensory pathway projecting to brain regions mediating the reduced feeding and exploration actions of systemic CCK.",
keywords = "Cholecystokinin, Exploratory behavior, Feeding behavior, Nucleus tractus solitarius, Peptides, Satiety",
author = "Jacqueline Crawley",
year = "1985",
doi = "10.1016/0196-9781(85)90022-1",
language = "English (US)",
volume = "6",
pages = "133--137",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Neurochemical investigation of the afferent pathway from the vagus nerve to the nucleus tractus solitarius in mediating the "satiety syndrome" induced by systemic cholecystokinin

AU - Crawley, Jacqueline

PY - 1985

Y1 - 1985

N2 - The satiety syndrome induced by intraperitoneally administered cholecystokinin (CCK) requires an intact visceral sensory feedback system involving the afferent vagus nerve [5, 22, 33] and the nucleus tractus solitarius (NTS) [9, 10]. Since both the vagus and the NTS contain CCK [25,37], the vagal-NTS synapse could conceivably employ CCK as a transmitter. To test this hypothesis, CCK was injected directly into the NTS region in awake rats. CCK at doses of 1 ng, 10 ng, and 100 ng had no effect on food consumption or exploratory behaviors associated with the satiety syndrome. The acetylcholine agonist carbachol, injected directly into the NTS region, effectively mimicked the actions of intraperitoneally administered CCK on feeding and exploration. These data suggest that CCK is not the transmitter at the vagal-NTS site in the visceral sensory pathway projecting to brain regions mediating the reduced feeding and exploration actions of systemic CCK.

AB - The satiety syndrome induced by intraperitoneally administered cholecystokinin (CCK) requires an intact visceral sensory feedback system involving the afferent vagus nerve [5, 22, 33] and the nucleus tractus solitarius (NTS) [9, 10]. Since both the vagus and the NTS contain CCK [25,37], the vagal-NTS synapse could conceivably employ CCK as a transmitter. To test this hypothesis, CCK was injected directly into the NTS region in awake rats. CCK at doses of 1 ng, 10 ng, and 100 ng had no effect on food consumption or exploratory behaviors associated with the satiety syndrome. The acetylcholine agonist carbachol, injected directly into the NTS region, effectively mimicked the actions of intraperitoneally administered CCK on feeding and exploration. These data suggest that CCK is not the transmitter at the vagal-NTS site in the visceral sensory pathway projecting to brain regions mediating the reduced feeding and exploration actions of systemic CCK.

KW - Cholecystokinin

KW - Exploratory behavior

KW - Feeding behavior

KW - Nucleus tractus solitarius

KW - Peptides

KW - Satiety

UR - http://www.scopus.com/inward/record.url?scp=0022380186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022380186&partnerID=8YFLogxK

U2 - 10.1016/0196-9781(85)90022-1

DO - 10.1016/0196-9781(85)90022-1

M3 - Article

C2 - 4047976

AN - SCOPUS:0022380186

VL - 6

SP - 133

EP - 137

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - SUPPL. 1

ER -