Abstract
Historically, studies of traumatic brain injury (TBI) have focused on metabolic, cerebral vascular, and structural pathology. However, significant recent progress has been made in understanding the biochemical features of TBI. Studies have determined that TBI can produce excessive excitation of neurons in the period immediately following impact. This excessive excitation of neurons can produce enduring pathologic changes in cell function that could result in many of the neurologic deficits characteristic of TBI. Clinically, these observations suggest that the administration of various pharmacologic agents that can blunt excessive excitation could improve the outcome of head-injured patients, if given soon after injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 16-28 |
| Number of pages | 13 |
| Journal | Journal of Head Trauma Rehabilitation |
| Volume | 7 |
| Issue number | 2 |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
- Rehabilitation
- Health Professions(all)
Cite this
Neurochemical aspects of head injury : Role of excitatory neurotransmission. / Hayes, R. L.; Jenkins, L. W.; Lyeth, Bruce G.
In: Journal of Head Trauma Rehabilitation, Vol. 7, No. 2, 1992, p. 16-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurochemical aspects of head injury
T2 - Role of excitatory neurotransmission
AU - Hayes, R. L.
AU - Jenkins, L. W.
AU - Lyeth, Bruce G
PY - 1992
Y1 - 1992
N2 - Historically, studies of traumatic brain injury (TBI) have focused on metabolic, cerebral vascular, and structural pathology. However, significant recent progress has been made in understanding the biochemical features of TBI. Studies have determined that TBI can produce excessive excitation of neurons in the period immediately following impact. This excessive excitation of neurons can produce enduring pathologic changes in cell function that could result in many of the neurologic deficits characteristic of TBI. Clinically, these observations suggest that the administration of various pharmacologic agents that can blunt excessive excitation could improve the outcome of head-injured patients, if given soon after injury.
AB - Historically, studies of traumatic brain injury (TBI) have focused on metabolic, cerebral vascular, and structural pathology. However, significant recent progress has been made in understanding the biochemical features of TBI. Studies have determined that TBI can produce excessive excitation of neurons in the period immediately following impact. This excessive excitation of neurons can produce enduring pathologic changes in cell function that could result in many of the neurologic deficits characteristic of TBI. Clinically, these observations suggest that the administration of various pharmacologic agents that can blunt excessive excitation could improve the outcome of head-injured patients, if given soon after injury.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026710966&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0026710966
VL - 7
SP - 16
EP - 28
JO - Journal of Head Trauma Rehabilitation
JF - Journal of Head Trauma Rehabilitation
SN - 0885-9701
IS - 2
ER -