Neuroblastoma presenting as central nervous system disease

Richard E Latchaw, P. R. L'Heureux, G. Young, J. R. Priest

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Neuroblastoma may be extremely difficult to recognize, particularly when the tumor presents as a primary central nervous system disease. Central nervous system involvement may be considered as primary intracerebral neuroblastoma, metastases to the cranium from an occult primary, primary intraorbital neuroblastoma originating in the ciliary ganglion, metastastic intraorbital neuroblastoma from an occult primary, primary intraspinal neuroblastoma originating in dorsal root ganglia, intraspinal metastatic disease, and distant effects such as myoclonic encephalopathy. Primary neuroblastoma within the ciliary ganglion and primary intraspinal neuroblastoma are extremely rare entities. Illustrative cases that demonstrate the broad spectrum of neurologic presentations are offered. The second known report of neuroblastoma in association with primary pulmonary hypoventilation (Ondine curse) is included.

Original languageEnglish (US)
Pages (from-to)623-630
Number of pages8
JournalAmerican Journal of Neuroradiology
Issue number6
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


Dive into the research topics of 'Neuroblastoma presenting as central nervous system disease'. Together they form a unique fingerprint.

Cite this