Neurobiology of simian and feline immunodeficiency virus infections

Andrew A. Lackner, Satya Dandekar, Murray B. Gardner

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Experimental and clinical evidence indicates that all lentiviruses of animals and humans are neurotropic and potentially neurovirulent. The prototypic animal lentiviruses, visna virus in sheep and caprine arthritis encephalitis virus in goats have been known for decades to induce neurologic disease. More recently, infection of the brain with the human immunodeficiency virus (HIV) has been linked to an associated encephalopathy and cognitive/motor complex. While the visna virus and caprine arthritis encephalitis virus are important models of neurologic disease they are not optimal for the study of HIV encephalitis because immune deficiency is only a minor component of the disease they induce. By contrast, the recently isolated lentiviruses from monkeys and cats, the simian and feline immunodeficiency viruses (SIV and FIV respectively), are profoundly immunosuppressive as well as neurotropic. SIV infection of the central nervous system of macaques now provides the best animal model for HIV infection of the human brain due to the close evolutionary relationship between monkeys and man, the genetic relatedness of their respective lentiviruses, and the similarities in the neuropathology. This chapter will compare and contrast the neurobiology of SIV and FIV with HIV.

Original languageEnglish (US)
Pages (from-to)201-212
Number of pages12
JournalBrain Pathology
Volume1
Issue number3
StatePublished - 1991
Externally publishedYes

Fingerprint

Feline Immunodeficiency Virus
Simian Immunodeficiency Virus
Lentivirus
Neurobiology
Virus Diseases
Caprine Arthritis-Encephalitis Viruses
Visna-maedi virus
HIV
Nervous System Diseases
Haplorhini
Central Nervous System Infections
Brain
Macaca
Brain Diseases
Encephalitis
Immunosuppressive Agents
Goats
Sheep
Cats
Animal Models

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Neurobiology of simian and feline immunodeficiency virus infections. / Lackner, Andrew A.; Dandekar, Satya; Gardner, Murray B.

In: Brain Pathology, Vol. 1, No. 3, 1991, p. 201-212.

Research output: Contribution to journalArticle

Lackner, AA, Dandekar, S & Gardner, MB 1991, 'Neurobiology of simian and feline immunodeficiency virus infections', Brain Pathology, vol. 1, no. 3, pp. 201-212.
Lackner, Andrew A. ; Dandekar, Satya ; Gardner, Murray B. / Neurobiology of simian and feline immunodeficiency virus infections. In: Brain Pathology. 1991 ; Vol. 1, No. 3. pp. 201-212.
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