Neuroanatomical assessment of biological maturity

Timothy T. Brown, Joshua M. Kuperman, Yoonho Chung, Matthew Erhart, Connor McCabe, Donald J. Hagler, Vijay K. Venkatraman, Natacha Akshoomoff, David G Amaral, Cinnamon S. Bloss, B. J. Casey, Linda Chang, Thomas M. Ernst, Jean A. Frazier, Jeffrey R. Gruen, Walter E. Kaufmann, Tal Kenet, David N. Kennedy, Sarah S. Murray, Elizabeth R. SowellTerry L. Jernigan, Anders M. Dale

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Structural MRI allows unparalleled in vivo study of the anatomy of the developing human brain. For more than two decades [1], MRI research has revealed many new aspects of this multifaceted maturation process, significantly augmenting scientific knowledge gathered from postmortem studies. Postnatal brain development is notably protracted and involves considerable changes in cerebral cortical [2-4], subcortical [5], and cerebellar [6, 7] structures, as well as significant architectural changes in white matter fiber tracts [8-11] (see [12]). Although much work has described isolated features of neuroanatomical development, it remains a critical challenge to characterize the multidimensional nature of brain anatomy, capturing different phases of development among individuals. Capitalizing on key advances in multisite, multimodal MRI, and using cross-validated nonlinear modeling, we demonstrate that developmental brain phase can be assessed with much greater precision than has been possible using other biological measures, accounting for more than 92% of the variance in age. Further, our composite metric of morphology, diffusivity, and signal intensity shows that the average difference in phase among children of the same age is only about 1 year, revealing for the first time a latent phenotype in the human brain for which maturation timing is tightly controlled. Video Abstract:

Original languageEnglish (US)
Pages (from-to)1693-1698
Number of pages6
JournalCurrent Biology
Volume22
Issue number18
DOIs
StatePublished - Sep 25 2012

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biological assessment
Brain
brain
Magnetic resonance imaging
Anatomy
personal development
in vivo studies
diffusivity
Phenotype
phenotype
Fibers
Composite materials
Research

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Brown, T. T., Kuperman, J. M., Chung, Y., Erhart, M., McCabe, C., Hagler, D. J., ... Dale, A. M. (2012). Neuroanatomical assessment of biological maturity. Current Biology, 22(18), 1693-1698. https://doi.org/10.1016/j.cub.2012.07.002

Neuroanatomical assessment of biological maturity. / Brown, Timothy T.; Kuperman, Joshua M.; Chung, Yoonho; Erhart, Matthew; McCabe, Connor; Hagler, Donald J.; Venkatraman, Vijay K.; Akshoomoff, Natacha; Amaral, David G; Bloss, Cinnamon S.; Casey, B. J.; Chang, Linda; Ernst, Thomas M.; Frazier, Jean A.; Gruen, Jeffrey R.; Kaufmann, Walter E.; Kenet, Tal; Kennedy, David N.; Murray, Sarah S.; Sowell, Elizabeth R.; Jernigan, Terry L.; Dale, Anders M.

In: Current Biology, Vol. 22, No. 18, 25.09.2012, p. 1693-1698.

Research output: Contribution to journalArticle

Brown, TT, Kuperman, JM, Chung, Y, Erhart, M, McCabe, C, Hagler, DJ, Venkatraman, VK, Akshoomoff, N, Amaral, DG, Bloss, CS, Casey, BJ, Chang, L, Ernst, TM, Frazier, JA, Gruen, JR, Kaufmann, WE, Kenet, T, Kennedy, DN, Murray, SS, Sowell, ER, Jernigan, TL & Dale, AM 2012, 'Neuroanatomical assessment of biological maturity', Current Biology, vol. 22, no. 18, pp. 1693-1698. https://doi.org/10.1016/j.cub.2012.07.002
Brown TT, Kuperman JM, Chung Y, Erhart M, McCabe C, Hagler DJ et al. Neuroanatomical assessment of biological maturity. Current Biology. 2012 Sep 25;22(18):1693-1698. https://doi.org/10.1016/j.cub.2012.07.002
Brown, Timothy T. ; Kuperman, Joshua M. ; Chung, Yoonho ; Erhart, Matthew ; McCabe, Connor ; Hagler, Donald J. ; Venkatraman, Vijay K. ; Akshoomoff, Natacha ; Amaral, David G ; Bloss, Cinnamon S. ; Casey, B. J. ; Chang, Linda ; Ernst, Thomas M. ; Frazier, Jean A. ; Gruen, Jeffrey R. ; Kaufmann, Walter E. ; Kenet, Tal ; Kennedy, David N. ; Murray, Sarah S. ; Sowell, Elizabeth R. ; Jernigan, Terry L. ; Dale, Anders M. / Neuroanatomical assessment of biological maturity. In: Current Biology. 2012 ; Vol. 22, No. 18. pp. 1693-1698.
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