Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

Kermit L Carraway, Janet L. Weber, Michelle J. Unger, Jessica Ledesma, Naichen Yu, Martin Gassmann, Cary Lai

Research output: Contribution to journalArticle

322 Citations (Scopus)

Abstract

The neuregulins (NRGs) are a family of multipotent epidermalgrowth- factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.

Original languageEnglish (US)
Pages (from-to)512-516
Number of pages5
JournalNature
Volume387
Issue number6632
DOIs
StatePublished - May 29 1997
Externally publishedYes

Fingerprint

Neuregulins
Receptor Protein-Tyrosine Kinases
Neuregulin-1
Ligands
Biological Phenomena
Genes
Tyrosine
Intercellular Signaling Peptides and Proteins
Phosphorylation
Brain
Growth

ASJC Scopus subject areas

  • General

Cite this

Carraway, K. L., Weber, J. L., Unger, M. J., Ledesma, J., Yu, N., Gassmann, M., & Lai, C. (1997). Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature, 387(6632), 512-516. https://doi.org/10.1038/387512a0

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. / Carraway, Kermit L; Weber, Janet L.; Unger, Michelle J.; Ledesma, Jessica; Yu, Naichen; Gassmann, Martin; Lai, Cary.

In: Nature, Vol. 387, No. 6632, 29.05.1997, p. 512-516.

Research output: Contribution to journalArticle

Carraway, KL, Weber, JL, Unger, MJ, Ledesma, J, Yu, N, Gassmann, M & Lai, C 1997, 'Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases', Nature, vol. 387, no. 6632, pp. 512-516. https://doi.org/10.1038/387512a0
Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M et al. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature. 1997 May 29;387(6632):512-516. https://doi.org/10.1038/387512a0
Carraway, Kermit L ; Weber, Janet L. ; Unger, Michelle J. ; Ledesma, Jessica ; Yu, Naichen ; Gassmann, Martin ; Lai, Cary. / Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. In: Nature. 1997 ; Vol. 387, No. 6632. pp. 512-516.
@article{2d12d085c6984221930ec94d0f3d51ca,
title = "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases",
abstract = "The neuregulins (NRGs) are a family of multipotent epidermalgrowth- factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.",
author = "Carraway, {Kermit L} and Weber, {Janet L.} and Unger, {Michelle J.} and Jessica Ledesma and Naichen Yu and Martin Gassmann and Cary Lai",
year = "1997",
month = "5",
day = "29",
doi = "10.1038/387512a0",
language = "English (US)",
volume = "387",
pages = "512--516",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6632",

}

TY - JOUR

T1 - Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

AU - Carraway, Kermit L

AU - Weber, Janet L.

AU - Unger, Michelle J.

AU - Ledesma, Jessica

AU - Yu, Naichen

AU - Gassmann, Martin

AU - Lai, Cary

PY - 1997/5/29

Y1 - 1997/5/29

N2 - The neuregulins (NRGs) are a family of multipotent epidermalgrowth- factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.

AB - The neuregulins (NRGs) are a family of multipotent epidermalgrowth- factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.

UR - http://www.scopus.com/inward/record.url?scp=0030974096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030974096&partnerID=8YFLogxK

U2 - 10.1038/387512a0

DO - 10.1038/387512a0

M3 - Article

C2 - 9168115

AN - SCOPUS:0030974096

VL - 387

SP - 512

EP - 516

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6632

ER -