Abstract
The neuregulins (NRGs) are a family of multipotent epidermalgrowth- factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 512-516 |
| Number of pages | 5 |
| Journal | Nature |
| Volume | 387 |
| Issue number | 6632 |
| DOIs | |
| State | Published - May 29 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
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Cite this
Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. / Carraway, Kermit L; Weber, Janet L.; Unger, Michelle J.; Ledesma, Jessica; Yu, Naichen; Gassmann, Martin; Lai, Cary.
In: Nature, Vol. 387, No. 6632, 29.05.1997, p. 512-516.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases
AU - Carraway, Kermit L
AU - Weber, Janet L.
AU - Unger, Michelle J.
AU - Ledesma, Jessica
AU - Yu, Naichen
AU - Gassmann, Martin
AU - Lai, Cary
PY - 1997/5/29
Y1 - 1997/5/29
N2 - The neuregulins (NRGs) are a family of multipotent epidermalgrowth- factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.
AB - The neuregulins (NRGs) are a family of multipotent epidermalgrowth- factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.
UR - http://www.scopus.com/inward/record.url?scp=0030974096&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030974096&partnerID=8YFLogxK
U2 - 10.1038/387512a0
DO - 10.1038/387512a0
M3 - Article
C2 - 9168115
AN - SCOPUS:0030974096
VL - 387
SP - 512
EP - 516
JO - Nature
JF - Nature
SN - 0028-0836
IS - 6632
ER -