Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

Kermit L Carraway, Janet L. Weber, Michelle J. Unger, Jessica Ledesma, Naichen Yu, Martin Gassmann, Cary Lai

Research output: Contribution to journalArticle

324 Scopus citations

Abstract

The neuregulins (NRGs) are a family of multipotent epidermalgrowth- factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.

Original languageEnglish (US)
Pages (from-to)512-516
Number of pages5
JournalNature
Volume387
Issue number6632
DOIs
StatePublished - May 29 1997
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases'. Together they form a unique fingerprint.

  • Cite this

    Carraway, K. L., Weber, J. L., Unger, M. J., Ledesma, J., Yu, N., Gassmann, M., & Lai, C. (1997). Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature, 387(6632), 512-516. https://doi.org/10.1038/387512a0