Current approaches to neural transplantation - adrenal medullary and fetal brain - suffer from limitations in tissue availability, cellular uniformity, and general applicability. The system described here uses temperaturesensitive immortalized clonal neural cells to address these limitations. Cerebellar cells, immortalized with a temperature-sensitive tumor virus, are transformed at 34°C, but differentiate at 38°C. The cells were genetically engineered to express beta-galactosidase, provid-ing a tag to study their fate in the host. The cells were then successfully transplanted to the cerebellum of adult rats.
|Original language||English (US)|
|Number of pages||3|
|Journal||Annals of Neurology|
|State||Published - Feb 1990|
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