Neural transplantation using temperature-sensitive immortalized neural cells: A preliminary report

Dale E. Bredesen, Kinya Hisanaga, Frank R Sharp

Research output: Contribution to journalArticle

28 Scopus citations


Current approaches to neural transplantation - adrenal medullary and fetal brain - suffer from limitations in tissue availability, cellular uniformity, and general applicability. The system described here uses temperaturesensitive immortalized clonal neural cells to address these limitations. Cerebellar cells, immortalized with a temperature-sensitive tumor virus, are transformed at 34°C, but differentiate at 38°C. The cells were genetically engineered to express beta-galactosidase, provid-ing a tag to study their fate in the host. The cells were then successfully transplanted to the cerebellum of adult rats.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalAnnals of Neurology
Issue number2
StatePublished - Feb 1990
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

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