Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress

Emily M. Drabant, Wiveka Ramel, Michael D. Edge, Luke W. Hyde, Janice R. Kuo, Philip R Goldin, Ahmad R. Hariri, James J. Gross

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objective: Many studies have shown that 5-HTTLPR genotype interacts with exposure to stress in conferring risk for psychopathology. However, the specific neural mechanisms through which this gene-by- environment interaction confers risk remain largely unknown, and no study to date has directly examined the modulatory effects of 5-HTTLPR on corticolimbic circuit responses during exposure to acute stress. Method: An acute laboratory stressor was administered to 51 healthy women during blood-oxygen-level-dependent functional magnetic resonance imaging. In this task, participants were threatened with electric shocks of uncertain intensity, which were unpredictably delivered to the wrist after a long anticipatory cue period of unpredictable duration. Results: Relative to women carrying the L allele, those with the SS genotype showed enhanced activation during threat anticipation in a network of regions, including the amygdala, hippocampus, anterior insula, thalamus, pulvinar, caudate, precuneus, anterior cingulate cortex, and medial prefrontal cortex. Individuals with the SS genotype also displayed enhanced positive coupling between medial prefrontal cortex activation and anxiety experience, whereas enhanced negative coupling between insula activation and perceived success at regulating anxiety was observed in individuals carrying the L allele. Conclusions: These findings suggest that during stress exposure, neural systems that enhance fear and arousal, modulate attention toward threat, and perseverate on emotional salience of the threat may be engaged preferentially in individuals with the SS genotype. This may be one mechanism underlying the risk for psychopathology conferred by the S allele upon exposure to life stressors.

Original languageEnglish (US)
Pages (from-to)397-405
Number of pages9
JournalAmerican Journal of Psychiatry
Volume169
Issue number4
DOIs
StatePublished - Apr 1 2012

Fingerprint

Genotype
Alleles
Prefrontal Cortex
Psychopathology
Anxiety
Pulvinar
Gene-Environment Interaction
Parietal Lobe
Gyrus Cinguli
Arousal
Amygdala
Wrist
Fear
Cues
Shock
Hippocampus
Magnetic Resonance Imaging
Oxygen

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Drabant, E. M., Ramel, W., Edge, M. D., Hyde, L. W., Kuo, J. R., Goldin, P. R., ... Gross, J. J. (2012). Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress. American Journal of Psychiatry, 169(4), 397-405. https://doi.org/10.1176/appi.ajp.2011.10111699

Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress. / Drabant, Emily M.; Ramel, Wiveka; Edge, Michael D.; Hyde, Luke W.; Kuo, Janice R.; Goldin, Philip R; Hariri, Ahmad R.; Gross, James J.

In: American Journal of Psychiatry, Vol. 169, No. 4, 01.04.2012, p. 397-405.

Research output: Contribution to journalArticle

Drabant, EM, Ramel, W, Edge, MD, Hyde, LW, Kuo, JR, Goldin, PR, Hariri, AR & Gross, JJ 2012, 'Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress', American Journal of Psychiatry, vol. 169, no. 4, pp. 397-405. https://doi.org/10.1176/appi.ajp.2011.10111699
Drabant, Emily M. ; Ramel, Wiveka ; Edge, Michael D. ; Hyde, Luke W. ; Kuo, Janice R. ; Goldin, Philip R ; Hariri, Ahmad R. ; Gross, James J. / Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress. In: American Journal of Psychiatry. 2012 ; Vol. 169, No. 4. pp. 397-405.
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