Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia

Stephen M. Wilson, Nina Dronkers, Jennifer M. Ogar, Jung Jang, Matthew E. Growdon, Federica Agosta, Maya L. Henry, Bruce L. Miller, Maria Luisa Gorno-Tempini

Research output: Contribution to journalArticle

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Abstract

The left posterior inferior frontal cortex (IFC) is important for syntactic processing, and has been shown in many functional imaging studies to be differentially recruited for the processing of syntactically complex sentences relative to simpler ones. In the nonfluent variant of primary progressive aphasia (PPA), degeneration of the posterior IFC is associated with expressive and receptive agrammatism; however, the functional status of this region in nonfluent PPA is not well understood. Our objective was to determine whether the atrophic posterior IFC is differentially recruited for the processing of syntactically complex sentences in nonfluent PPA. Using structural and functional magnetic resonance imaging, we quantified tissue volumes and functional responses to a syntactic comprehension task in eight patients with nonfluent PPA, compared to healthy age-matched controls. In controls, the posterior IFC showed more activity for syntactically complex sentences than simpler ones, as expected. In nonfluent PPA patients, the posterior IFC was atrophic and, unlike controls, showed an equivalent level of functional activity for syntactically complex and simpler sentences. This abnormal pattern of functional activity was specific to the posterior IFC: the mid-superior temporal sulcus, another region modulated by syntactic complexity in controls, showed normal modulation by complexity in patients. A more anterior inferior frontal region was recruited by patients, but did not support successful syntactic processing. We conclude that in nonfluent PPA, the posterior IFC is not only structurally damaged, but also functionally abnormal, suggesting a critical role for this region in the breakdown of syntactic processing in this syndrome.

Original languageEnglish (US)
Pages (from-to)16845-16854
Number of pages10
JournalJournal of Neuroscience
Volume30
Issue number50
DOIs
StatePublished - Dec 15 2010

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Primary Progressive Nonfluent Aphasia
Frontal Lobe
Broca Aphasia
Temporal Lobe
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wilson, S. M., Dronkers, N., Ogar, J. M., Jang, J., Growdon, M. E., Agosta, F., ... Gorno-Tempini, M. L. (2010). Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia. Journal of Neuroscience, 30(50), 16845-16854. https://doi.org/10.1523/JNEUROSCI.2547-10.2010

Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia. / Wilson, Stephen M.; Dronkers, Nina; Ogar, Jennifer M.; Jang, Jung; Growdon, Matthew E.; Agosta, Federica; Henry, Maya L.; Miller, Bruce L.; Gorno-Tempini, Maria Luisa.

In: Journal of Neuroscience, Vol. 30, No. 50, 15.12.2010, p. 16845-16854.

Research output: Contribution to journalArticle

Wilson, SM, Dronkers, N, Ogar, JM, Jang, J, Growdon, ME, Agosta, F, Henry, ML, Miller, BL & Gorno-Tempini, ML 2010, 'Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia', Journal of Neuroscience, vol. 30, no. 50, pp. 16845-16854. https://doi.org/10.1523/JNEUROSCI.2547-10.2010
Wilson, Stephen M. ; Dronkers, Nina ; Ogar, Jennifer M. ; Jang, Jung ; Growdon, Matthew E. ; Agosta, Federica ; Henry, Maya L. ; Miller, Bruce L. ; Gorno-Tempini, Maria Luisa. / Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 50. pp. 16845-16854.
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