Neural correlates of pair-bonding in a monogamous primate

Karen L. Bales, William A. Mason, Ciprian Catana, Simon R Cherry, Sally P. Mendoza

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The neurobiology of social bonding, despite its relevance to human mental health, has been studied primarily in rodents. In this study we used position emission tomography (PET), registered with structural magnetic resonance imaging (MRI) to investigate central glucose uptake in 17 males of a monogamous primate species, the titi monkey (Callicebus cupreus). Twelve pair-bonded males (including six with a lesion of the prefrontal cortex) and five lone males were scanned. The five lone males were re-scanned 48 h after pairing with a female. Significant differences in glucose uptake were found between males in long-term pair-bonds and lone males in areas including the nucleus accumbens, ventral pallidum, medial preoptic area, medial amygdala, and the supraoptic nucleus of the hypothalamus. In paired before and after comparisons, males showed significant changes following pairing in the right nucleus accumbens and ventral pallidum but not in other areas. Lesioned males showed significantly higher uptake in the posterior cingulate cortex than all other males. These results indicate some basic similarities between rodents and primates in the formation and maintenance of selective social bonds, but emphasize the importance of studying long-term maintenance in addition to short-term formation of social bonds.

Original languageEnglish (US)
Pages (from-to)245-253
Number of pages9
JournalBrain Research
Volume1184
Issue number1
DOIs
StatePublished - Dec 12 2007

Fingerprint

Primates
Nucleus Accumbens
Pitheciidae
Rodentia
Pair Bond
Object Attachment
Glucose
Supraoptic Nucleus
Preoptic Area
Neurobiology
Gyrus Cinguli
Amygdala
Prefrontal Cortex
Haplorhini
Mental Health
Tomography
Magnetic Resonance Imaging

Keywords

  • Monogamy
  • Oxytocin
  • Social bonding
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Neural correlates of pair-bonding in a monogamous primate. / Bales, Karen L.; Mason, William A.; Catana, Ciprian; Cherry, Simon R; Mendoza, Sally P.

In: Brain Research, Vol. 1184, No. 1, 12.12.2007, p. 245-253.

Research output: Contribution to journalArticle

Bales, KL, Mason, WA, Catana, C, Cherry, SR & Mendoza, SP 2007, 'Neural correlates of pair-bonding in a monogamous primate', Brain Research, vol. 1184, no. 1, pp. 245-253. https://doi.org/10.1016/j.brainres.2007.09.087
Bales, Karen L. ; Mason, William A. ; Catana, Ciprian ; Cherry, Simon R ; Mendoza, Sally P. / Neural correlates of pair-bonding in a monogamous primate. In: Brain Research. 2007 ; Vol. 1184, No. 1. pp. 245-253.
@article{71656c9779704fec978e5e6eb1ccb55e,
title = "Neural correlates of pair-bonding in a monogamous primate",
abstract = "The neurobiology of social bonding, despite its relevance to human mental health, has been studied primarily in rodents. In this study we used position emission tomography (PET), registered with structural magnetic resonance imaging (MRI) to investigate central glucose uptake in 17 males of a monogamous primate species, the titi monkey (Callicebus cupreus). Twelve pair-bonded males (including six with a lesion of the prefrontal cortex) and five lone males were scanned. The five lone males were re-scanned 48 h after pairing with a female. Significant differences in glucose uptake were found between males in long-term pair-bonds and lone males in areas including the nucleus accumbens, ventral pallidum, medial preoptic area, medial amygdala, and the supraoptic nucleus of the hypothalamus. In paired before and after comparisons, males showed significant changes following pairing in the right nucleus accumbens and ventral pallidum but not in other areas. Lesioned males showed significantly higher uptake in the posterior cingulate cortex than all other males. These results indicate some basic similarities between rodents and primates in the formation and maintenance of selective social bonds, but emphasize the importance of studying long-term maintenance in addition to short-term formation of social bonds.",
keywords = "Monogamy, Oxytocin, Social bonding, Vasopressin",
author = "Bales, {Karen L.} and Mason, {William A.} and Ciprian Catana and Cherry, {Simon R} and Mendoza, {Sally P.}",
year = "2007",
month = "12",
day = "12",
doi = "10.1016/j.brainres.2007.09.087",
language = "English (US)",
volume = "1184",
pages = "245--253",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Neural correlates of pair-bonding in a monogamous primate

AU - Bales, Karen L.

AU - Mason, William A.

AU - Catana, Ciprian

AU - Cherry, Simon R

AU - Mendoza, Sally P.

PY - 2007/12/12

Y1 - 2007/12/12

N2 - The neurobiology of social bonding, despite its relevance to human mental health, has been studied primarily in rodents. In this study we used position emission tomography (PET), registered with structural magnetic resonance imaging (MRI) to investigate central glucose uptake in 17 males of a monogamous primate species, the titi monkey (Callicebus cupreus). Twelve pair-bonded males (including six with a lesion of the prefrontal cortex) and five lone males were scanned. The five lone males were re-scanned 48 h after pairing with a female. Significant differences in glucose uptake were found between males in long-term pair-bonds and lone males in areas including the nucleus accumbens, ventral pallidum, medial preoptic area, medial amygdala, and the supraoptic nucleus of the hypothalamus. In paired before and after comparisons, males showed significant changes following pairing in the right nucleus accumbens and ventral pallidum but not in other areas. Lesioned males showed significantly higher uptake in the posterior cingulate cortex than all other males. These results indicate some basic similarities between rodents and primates in the formation and maintenance of selective social bonds, but emphasize the importance of studying long-term maintenance in addition to short-term formation of social bonds.

AB - The neurobiology of social bonding, despite its relevance to human mental health, has been studied primarily in rodents. In this study we used position emission tomography (PET), registered with structural magnetic resonance imaging (MRI) to investigate central glucose uptake in 17 males of a monogamous primate species, the titi monkey (Callicebus cupreus). Twelve pair-bonded males (including six with a lesion of the prefrontal cortex) and five lone males were scanned. The five lone males were re-scanned 48 h after pairing with a female. Significant differences in glucose uptake were found between males in long-term pair-bonds and lone males in areas including the nucleus accumbens, ventral pallidum, medial preoptic area, medial amygdala, and the supraoptic nucleus of the hypothalamus. In paired before and after comparisons, males showed significant changes following pairing in the right nucleus accumbens and ventral pallidum but not in other areas. Lesioned males showed significantly higher uptake in the posterior cingulate cortex than all other males. These results indicate some basic similarities between rodents and primates in the formation and maintenance of selective social bonds, but emphasize the importance of studying long-term maintenance in addition to short-term formation of social bonds.

KW - Monogamy

KW - Oxytocin

KW - Social bonding

KW - Vasopressin

UR - http://www.scopus.com/inward/record.url?scp=36348976463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36348976463&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2007.09.087

DO - 10.1016/j.brainres.2007.09.087

M3 - Article

VL - 1184

SP - 245

EP - 253

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -