Abstract
Neural cell adhesion molecules (N-CAMs) are expressed in neuromuscular tissues, neuroblostoma, and small cell lung carcinoma. Adenoid cystic carcinoma may invade the skull by either direct extension or neural involvement, particularly along the second and third divisions of the trigeminal nerve (V2 and V3). Eighteen patients with adenoid cystic carcinoma that invaded the skull base were studied. The tumors were graded into predominantly solid (3), Cribriform (11), or tubular-trabecular (4) patterns, and neural involvement was evaluated histologically. Paraffin sections were examined by use of monoclonal antibodies for N-CAM and Ki-67, a proliferation marker, with the avidin-biotin-peroxidase method. Fifteen (83%) tumors showed perineural involvement; in the remaining three cases no nerves were present for histologic examination. Fourteen (93%) of 15 tumors with perieural involvement were reactive with N-CAM. Proliferation, measured by the presence of nuclear Ki-67, was markedly increased in tumors with predominantly solid patterns. We demonstrated that N-CAM is expressed in adenoid cystic carcinoma. The role of N-CAM as a neurodeterminant that facilitates the spread of adenoid cystic carcinoma along nerves, however, remains unanswered and warrants further study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 453-458 |
| Number of pages | 6 |
| Journal | Otolaryngology - Head and Neck Surgery |
| Volume | 117 |
| Issue number | 5 |
| State | Published - 1997 |
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ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Neural cell adhesion molecule in adenoid cystic carcinoma invading the skull base. / Gandour-Edwards, Regina F; Kapadia, S. B.; Barnes, L.; Donald, P. J.; Janecka, I. P.
In: Otolaryngology - Head and Neck Surgery, Vol. 117, No. 5, 1997, p. 453-458.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neural cell adhesion molecule in adenoid cystic carcinoma invading the skull base
AU - Gandour-Edwards, Regina F
AU - Kapadia, S. B.
AU - Barnes, L.
AU - Donald, P. J.
AU - Janecka, I. P.
PY - 1997
Y1 - 1997
N2 - Neural cell adhesion molecules (N-CAMs) are expressed in neuromuscular tissues, neuroblostoma, and small cell lung carcinoma. Adenoid cystic carcinoma may invade the skull by either direct extension or neural involvement, particularly along the second and third divisions of the trigeminal nerve (V2 and V3). Eighteen patients with adenoid cystic carcinoma that invaded the skull base were studied. The tumors were graded into predominantly solid (3), Cribriform (11), or tubular-trabecular (4) patterns, and neural involvement was evaluated histologically. Paraffin sections were examined by use of monoclonal antibodies for N-CAM and Ki-67, a proliferation marker, with the avidin-biotin-peroxidase method. Fifteen (83%) tumors showed perineural involvement; in the remaining three cases no nerves were present for histologic examination. Fourteen (93%) of 15 tumors with perieural involvement were reactive with N-CAM. Proliferation, measured by the presence of nuclear Ki-67, was markedly increased in tumors with predominantly solid patterns. We demonstrated that N-CAM is expressed in adenoid cystic carcinoma. The role of N-CAM as a neurodeterminant that facilitates the spread of adenoid cystic carcinoma along nerves, however, remains unanswered and warrants further study.
AB - Neural cell adhesion molecules (N-CAMs) are expressed in neuromuscular tissues, neuroblostoma, and small cell lung carcinoma. Adenoid cystic carcinoma may invade the skull by either direct extension or neural involvement, particularly along the second and third divisions of the trigeminal nerve (V2 and V3). Eighteen patients with adenoid cystic carcinoma that invaded the skull base were studied. The tumors were graded into predominantly solid (3), Cribriform (11), or tubular-trabecular (4) patterns, and neural involvement was evaluated histologically. Paraffin sections were examined by use of monoclonal antibodies for N-CAM and Ki-67, a proliferation marker, with the avidin-biotin-peroxidase method. Fifteen (83%) tumors showed perineural involvement; in the remaining three cases no nerves were present for histologic examination. Fourteen (93%) of 15 tumors with perieural involvement were reactive with N-CAM. Proliferation, measured by the presence of nuclear Ki-67, was markedly increased in tumors with predominantly solid patterns. We demonstrated that N-CAM is expressed in adenoid cystic carcinoma. The role of N-CAM as a neurodeterminant that facilitates the spread of adenoid cystic carcinoma along nerves, however, remains unanswered and warrants further study.
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M3 - Article
C2 - 9374166
AN - SCOPUS:0030682122
VL - 117
SP - 453
EP - 458
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
SN - 0194-5998
IS - 5
ER -