Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor α-subunit expression in the mammalian pinealocyte: A neuroendocrine/immune response link?

Surajit Ganguly, Ana Grodzki, David Sugden, Morten Møller, Sandra Odom, Pascaline Gaildrat, Igal Gery, Reuben P. Siraganian, Juan Rivera, David C. Klein

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The high affinity immunoglobulin E receptor (FcεRI) complex is dedicated to immunoglobulin E-mediated allergic responses. Expression of the FcεRI receptor is thought to be relatively stable and limited to mast cells, basophils, eosinophils, monocytes, Langerhans cells, platelets, and neutrophils. We now report that the FcεRIα and FcεRIγ polypeptides are expressed in the pinealocyte, the melatonin-secreting cell of the pineal gland. Moreover, Fcer1a mRNA levels increased ∼100-fold at night to levels that were higher than in other tissues examined. Pineal FcεRIα protein also increased markedly at night from nearly undetectable daytime levels. Our studies indicate that pineal Fcer1a mRNA levels are controlled by a well described neural pathway that controls pineal function. This pathway includes the master circadian oscillator in the suprachiasmatic nucleus and passes through central and peripheral structures. The circadian expression of FcεRIα in the pineal gland is driven by this neural circuit via an adrenergic/cyclic AMP mechanism. Pineal FcεRIα and FcεRIγ may represent a previously unrealized molecular link between the neuroendocrine and immune systems.

Original languageEnglish (US)
Pages (from-to)32758-32764
Number of pages7
JournalJournal of Biological Chemistry
Volume282
Issue number45
DOIs
StatePublished - Nov 9 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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