Abstract
This study examined the neural correlates of cue-induced anger in cocaine-dependent men in an initial investigation of possible neurobiological explanations for the putative association between cocaine addiction and violence. We used positron emission tomography (PET) to localize alterations in regional cerebral blood flow (rCBF) during mental imagery of a personal anger-associated scene and of an emotionally neutral scene in ten cocaine-dependent men. Compared to the emotionally neutral imagery control condition, anger was associated with marked decreases in rCBF in multiple areas of the frontal cortex (particularly the right inferior frontal gyrus), left posterior insula, left fusiform gyrus, and midbrain. Conversely, this same inferior frontal area was activated by anger imagery in nicotine-dependent men. Anger was also associated with increases in rCBF in the right fusiform gyrus, right and left middle occipital gyri, left postcentral gyrus, left medial frontal gyrus, left cuneus, and in the left anterior cingulate gyrus. The study showed that cue-induced anger in cocaine-dependent men was associated with decreased activity in frontal cortical areas involved in response monitoring and inhibition. The lack of this association in nicotine-dependent men suggests a possible deficit in anger regulation associated with cocaine dependence and a possible link between cocaine dependence, violence, and relapse.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 331-339 |
| Number of pages | 9 |
| Journal | American Journal on Addictions |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
Cite this
Neural activity related to anger in cocaine-dependent men : A possible link to violence and relapse. / Drexler, K.; Schweitzer, Julie B; Quinn, C. K.; Gross, R.; Ely, T. D.; Muhammad, F.; Kilts, C. D.
In: American Journal on Addictions, Vol. 9, No. 4, 2000, p. 331-339.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neural activity related to anger in cocaine-dependent men
T2 - A possible link to violence and relapse
AU - Drexler, K.
AU - Schweitzer, Julie B
AU - Quinn, C. K.
AU - Gross, R.
AU - Ely, T. D.
AU - Muhammad, F.
AU - Kilts, C. D.
PY - 2000
Y1 - 2000
N2 - This study examined the neural correlates of cue-induced anger in cocaine-dependent men in an initial investigation of possible neurobiological explanations for the putative association between cocaine addiction and violence. We used positron emission tomography (PET) to localize alterations in regional cerebral blood flow (rCBF) during mental imagery of a personal anger-associated scene and of an emotionally neutral scene in ten cocaine-dependent men. Compared to the emotionally neutral imagery control condition, anger was associated with marked decreases in rCBF in multiple areas of the frontal cortex (particularly the right inferior frontal gyrus), left posterior insula, left fusiform gyrus, and midbrain. Conversely, this same inferior frontal area was activated by anger imagery in nicotine-dependent men. Anger was also associated with increases in rCBF in the right fusiform gyrus, right and left middle occipital gyri, left postcentral gyrus, left medial frontal gyrus, left cuneus, and in the left anterior cingulate gyrus. The study showed that cue-induced anger in cocaine-dependent men was associated with decreased activity in frontal cortical areas involved in response monitoring and inhibition. The lack of this association in nicotine-dependent men suggests a possible deficit in anger regulation associated with cocaine dependence and a possible link between cocaine dependence, violence, and relapse.
AB - This study examined the neural correlates of cue-induced anger in cocaine-dependent men in an initial investigation of possible neurobiological explanations for the putative association between cocaine addiction and violence. We used positron emission tomography (PET) to localize alterations in regional cerebral blood flow (rCBF) during mental imagery of a personal anger-associated scene and of an emotionally neutral scene in ten cocaine-dependent men. Compared to the emotionally neutral imagery control condition, anger was associated with marked decreases in rCBF in multiple areas of the frontal cortex (particularly the right inferior frontal gyrus), left posterior insula, left fusiform gyrus, and midbrain. Conversely, this same inferior frontal area was activated by anger imagery in nicotine-dependent men. Anger was also associated with increases in rCBF in the right fusiform gyrus, right and left middle occipital gyri, left postcentral gyrus, left medial frontal gyrus, left cuneus, and in the left anterior cingulate gyrus. The study showed that cue-induced anger in cocaine-dependent men was associated with decreased activity in frontal cortical areas involved in response monitoring and inhibition. The lack of this association in nicotine-dependent men suggests a possible deficit in anger regulation associated with cocaine dependence and a possible link between cocaine dependence, violence, and relapse.
UR - http://www.scopus.com/inward/record.url?scp=0034528929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034528929&partnerID=8YFLogxK
U2 - 10.1080/105504900750047382
DO - 10.1080/105504900750047382
M3 - Article
C2 - 11155786
AN - SCOPUS:0034528929
VL - 9
SP - 331
EP - 339
JO - American Journal on Addictions
JF - American Journal on Addictions
SN - 1055-0496
IS - 4
ER -