Nesidioblastosis associated with hyperglycemia in two squirrel monkeys (Saimiri sciureus)

C. S. King, J. W. Streett, K. D. Moody, Stephen W Barthold

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Nesidioblastosis associated with progressive weight loss and hyperglycemia was diagnosed in two mid-adult, wild-caught, male squirrel monkeys (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hypothermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained predominantly glucagon-positive in the most severely affected monkey.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalJournal of Medical Primatology
Volume25
Issue number5
StatePublished - Oct 1996
Externally publishedYes

Keywords

  • Diabetes mellitus
  • Immunohistochemistry
  • Pancreas

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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