Abstract
Nesidioblastosis associated with progressive weight loss and hyperglycemia was diagnosed in two mid-adult, wild-caught, male squirrel monkeys (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hypothermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained predominantly glucagon-positive in the most severely affected monkey.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 361-366 |
| Number of pages | 6 |
| Journal | Journal of Medical Primatology |
| Volume | 25 |
| Issue number | 5 |
| State | Published - Oct 1996 |
| Externally published | Yes |
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Keywords
- Diabetes mellitus
- Immunohistochemistry
- Pancreas
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Nesidioblastosis associated with hyperglycemia in two squirrel monkeys (Saimiri sciureus). / King, C. S.; Streett, J. W.; Moody, K. D.; Barthold, Stephen W.
In: Journal of Medical Primatology, Vol. 25, No. 5, 10.1996, p. 361-366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nesidioblastosis associated with hyperglycemia in two squirrel monkeys (Saimiri sciureus)
AU - King, C. S.
AU - Streett, J. W.
AU - Moody, K. D.
AU - Barthold, Stephen W
PY - 1996/10
Y1 - 1996/10
N2 - Nesidioblastosis associated with progressive weight loss and hyperglycemia was diagnosed in two mid-adult, wild-caught, male squirrel monkeys (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hypothermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained predominantly glucagon-positive in the most severely affected monkey.
AB - Nesidioblastosis associated with progressive weight loss and hyperglycemia was diagnosed in two mid-adult, wild-caught, male squirrel monkeys (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hypothermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained predominantly glucagon-positive in the most severely affected monkey.
KW - Diabetes mellitus
KW - Immunohistochemistry
KW - Pancreas
UR - http://www.scopus.com/inward/record.url?scp=0030256188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030256188&partnerID=8YFLogxK
M3 - Article
VL - 25
SP - 361
EP - 366
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 5
ER -