Nesidioblastosis associated with progressive weight loss and hyperglycemia was diagnosed in two mid-adult, wild-caught, male squirrel monkeys (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hypothermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained predominantly glucagon-positive in the most severely affected monkey.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Medical Primatology|
|State||Published - Oct 1996|
- Diabetes mellitus
ASJC Scopus subject areas
- Animal Science and Zoology