Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo

Bing Song, Min Zhao, John Forrester, Colin McCaig

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

Biological roles for naturally occurring, extracellular physiological electric fields have been proposed over the past century. However, in the molecular era, many biologists presume that electric fields have little physiological relevance because there has been no unequivocal demonstration of their importance at the single-cell level in vivo. We have used an in vivo rat corneal model, which generates its own endogenous electric field and show that nerve sprouting, the direction of nerve growth and the rate of epithelial wound healing are controlled coordinately by the wound-induced electric field.

Original languageEnglish (US)
Pages (from-to)4681-4690
Number of pages10
JournalJournal of Cell Science
Volume117
Issue number20
DOIs
StatePublished - Sep 15 2004
Externally publishedYes

Keywords

  • Cornea
  • Electric field
  • Nerve regeneration
  • Wound healing

ASJC Scopus subject areas

  • Cell Biology

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