Abstract
We examined the preventive effects of nerve growth factor (NGF) against neurotoxicity induced in aged rats by anti-cancer drugs such as cisplatin, vincristine and taxol using a superior cervical ganglion explant culture system. The inhibition of neurite outgrowth by cisplatin, vincristine and taxol was markedly prevented by co-treatment with NGF. The neurite and nerve cell populations were well preserved in vincristine and taxol, whereas cisplatin reduced these populations as compared with control even when treated with NGF. These results indicate that, just as in young adult rats, NGF prevents toxic sympathetic nerve injury induced by vincristine and taxol even in aged rats, but dose not protect against cisplatin-induced nerve cell injury. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-106 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 274 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 22 1999 |
| Externally published | Yes |
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Keywords
- Aged rats
- Cisplatin
- Nerve growth factor
- Superior cervical ganglia
- Taxol
- Vincristine
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Nerve growth factor prevention of aged-rat sympathetic neuron injury by cisplatin, vincristine and taxol - in vitro explant study. / Hayakawa, Kazuhiro; Ito, Takayuki; Niwa, Hisayoshi; Yamamoto, Masahiko; Liang, Yideng; Doyu, Manabu; Sobue, Gen.
In: Neuroscience Letters, Vol. 274, No. 2, 22.10.1999, p. 103-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nerve growth factor prevention of aged-rat sympathetic neuron injury by cisplatin, vincristine and taxol - in vitro explant study
AU - Hayakawa, Kazuhiro
AU - Ito, Takayuki
AU - Niwa, Hisayoshi
AU - Yamamoto, Masahiko
AU - Liang, Yideng
AU - Doyu, Manabu
AU - Sobue, Gen
PY - 1999/10/22
Y1 - 1999/10/22
N2 - We examined the preventive effects of nerve growth factor (NGF) against neurotoxicity induced in aged rats by anti-cancer drugs such as cisplatin, vincristine and taxol using a superior cervical ganglion explant culture system. The inhibition of neurite outgrowth by cisplatin, vincristine and taxol was markedly prevented by co-treatment with NGF. The neurite and nerve cell populations were well preserved in vincristine and taxol, whereas cisplatin reduced these populations as compared with control even when treated with NGF. These results indicate that, just as in young adult rats, NGF prevents toxic sympathetic nerve injury induced by vincristine and taxol even in aged rats, but dose not protect against cisplatin-induced nerve cell injury. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - We examined the preventive effects of nerve growth factor (NGF) against neurotoxicity induced in aged rats by anti-cancer drugs such as cisplatin, vincristine and taxol using a superior cervical ganglion explant culture system. The inhibition of neurite outgrowth by cisplatin, vincristine and taxol was markedly prevented by co-treatment with NGF. The neurite and nerve cell populations were well preserved in vincristine and taxol, whereas cisplatin reduced these populations as compared with control even when treated with NGF. These results indicate that, just as in young adult rats, NGF prevents toxic sympathetic nerve injury induced by vincristine and taxol even in aged rats, but dose not protect against cisplatin-induced nerve cell injury. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - Aged rats
KW - Cisplatin
KW - Nerve growth factor
KW - Superior cervical ganglia
KW - Taxol
KW - Vincristine
UR - http://www.scopus.com/inward/record.url?scp=0032853221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032853221&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(99)00689-8
DO - 10.1016/S0304-3940(99)00689-8
M3 - Article
C2 - 10553948
AN - SCOPUS:0032853221
VL - 274
SP - 103
EP - 106
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -