Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration

Mark H. Tuszynski, Hoi Sang U, David G Amaral, Fred H. Gage

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

NGF is a protein that promotes survival, differentiation, and process extension of selected neuronal populations during development and, in some cases, in the mature organism. Previous lesion and aging studies in the rat have shown that intracerebroventricular NGF infusions can prevent degenerative changes in basal forebrain cholinergic neurons. We sought to determine whether salutory effects of NGF occur in the primate brain. Cholinergic fibers of the septohippocampal projection in the primate were surgically transected, followed by infusion of either a vehicle or an NGF solution into the ventricular system for a 4-week period. Quantification of cholinergic neurons in the medial septal nucleus at the end of the infusion period demonstrated that only 45 ± 5% of cholinergic neurons could be identified after fornix lesions in vehicle-infused animals, whereas 80 ± 6% of neurons were visible in NGF-treated animals. Thus, NGF substantially reduced lesion-induced cholinergic neuronal degeneration in the adult primate brain. This finding may be relevant to the hypothesis that NGF has potential use as a cholinergic "neurotrophic-factor therapy," given that loss of basal forebrain cholinergic neurons is common in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)3604-3614
Number of pages11
JournalJournal of Neuroscience
Volume10
Issue number11
StatePublished - 1990

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Nerve Growth Factor
Cholinergic Agents
Primates
Cholinergic Neurons
Brain
Cholinergic Fibers
Intraventricular Infusions
Septal Nuclei
Nerve Growth Factors
Alzheimer Disease
Neurons
Population
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

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Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. / Tuszynski, Mark H.; Sang U, Hoi; Amaral, David G; Gage, Fred H.

In: Journal of Neuroscience, Vol. 10, No. 11, 1990, p. 3604-3614.

Research output: Contribution to journalArticle

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