Neovaginal malignant melanoma following surgery and radiation for vulvar squamous cell carcinoma

Primo N Lara, Edward Hearn, Bryan Leigh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The causal link between therapeutic irradiation and malignant melanoma has not been firmly established. The authors report a novel case of a malignant melanoma arising from a therapeutically irradiated neovagina reconstructed from skin flaps following radical vulvectomy with inguinal lymph node dissection 16 years earlier. The diagnosis was established by light microscopy and immunohistochemical staining. Reports of melanoma arising from sites of previous radiation therapy are reviewed. Our observations suggest that therapeutic radiation may be a factor in the development of malignant melanoma, particularly in non-sun-exposed areas, including the genital tract.

Original languageEnglish (US)
Pages (from-to)520-522
Number of pages3
JournalGynecologic Oncology
Volume65
Issue number3
DOIs
StatePublished - Jun 1997

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Squamous Cell Carcinoma
Melanoma
Radiation
Groin
Lymph Node Excision
Microscopy
Radiotherapy
Staining and Labeling
Light
Skin
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Neovaginal malignant melanoma following surgery and radiation for vulvar squamous cell carcinoma. / Lara, Primo N; Hearn, Edward; Leigh, Bryan.

In: Gynecologic Oncology, Vol. 65, No. 3, 06.1997, p. 520-522.

Research output: Contribution to journalArticle

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