Abstract
Male transgenic mice expressing the polyomavirus middle T (PyV-MT) gene exhibited growth and developmental abnormalities in prostatic and other urogenital epithelium. Expression of PyV-MT was directed to these tissues by a novel, androgen-inducible expression vector based on the rat C3(1) gene. Epithelial growth disturbances (hyperplasia, dysplasia, and invasive carcinoma) were observed in the ventral and dorsal prostate, coagulating gland, epididymis, and vas deferens. The abnormalities were characterized by histological disorganization, nuclear pleomorphism, increased mitoses, and ab normal DNA content. Transgene transcription was detected in affected tissues, indicating that the C3(1)-based vector targeted androgen-sensitive urogenital tissues, especially the prostate. These results demonstrated that expression of a gene, the protein of which is known to interact with cellular proteins involved in signal transduction, dramatically disrupted urogenital growth and development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1177-1191 |
| Number of pages | 15 |
| Journal | American Journal of Pathology |
| Volume | 149 |
| Issue number | 4 |
| State | Published - Oct 1996 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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Neoplastic transformation of prostatic and urogenital epithelium by the polyoma virus middle T gene. / Tehranian, Arash; Morris, David W.; Min, Byung Hee; Bird, Dana J.; Cardiff, Robert; Barry, Peter A.
In: American Journal of Pathology, Vol. 149, No. 4, 10.1996, p. 1177-1191.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neoplastic transformation of prostatic and urogenital epithelium by the polyoma virus middle T gene
AU - Tehranian, Arash
AU - Morris, David W.
AU - Min, Byung Hee
AU - Bird, Dana J.
AU - Cardiff, Robert
AU - Barry, Peter A
PY - 1996/10
Y1 - 1996/10
N2 - Male transgenic mice expressing the polyomavirus middle T (PyV-MT) gene exhibited growth and developmental abnormalities in prostatic and other urogenital epithelium. Expression of PyV-MT was directed to these tissues by a novel, androgen-inducible expression vector based on the rat C3(1) gene. Epithelial growth disturbances (hyperplasia, dysplasia, and invasive carcinoma) were observed in the ventral and dorsal prostate, coagulating gland, epididymis, and vas deferens. The abnormalities were characterized by histological disorganization, nuclear pleomorphism, increased mitoses, and ab normal DNA content. Transgene transcription was detected in affected tissues, indicating that the C3(1)-based vector targeted androgen-sensitive urogenital tissues, especially the prostate. These results demonstrated that expression of a gene, the protein of which is known to interact with cellular proteins involved in signal transduction, dramatically disrupted urogenital growth and development.
AB - Male transgenic mice expressing the polyomavirus middle T (PyV-MT) gene exhibited growth and developmental abnormalities in prostatic and other urogenital epithelium. Expression of PyV-MT was directed to these tissues by a novel, androgen-inducible expression vector based on the rat C3(1) gene. Epithelial growth disturbances (hyperplasia, dysplasia, and invasive carcinoma) were observed in the ventral and dorsal prostate, coagulating gland, epididymis, and vas deferens. The abnormalities were characterized by histological disorganization, nuclear pleomorphism, increased mitoses, and ab normal DNA content. Transgene transcription was detected in affected tissues, indicating that the C3(1)-based vector targeted androgen-sensitive urogenital tissues, especially the prostate. These results demonstrated that expression of a gene, the protein of which is known to interact with cellular proteins involved in signal transduction, dramatically disrupted urogenital growth and development.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029794270&partnerID=8YFLogxK
M3 - Article
C2 - 8863667
AN - SCOPUS:0029794270
VL - 149
SP - 1177
EP - 1191
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 4
ER -