Neonatal pulmonary hypertension

Robin H Steinhorn

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

When the normal cardiopulmonary transition fails to occur, the result is persistent pulmonary hypertension of the newborn. Severe persistent pulmonary hypertension of the newborn is estimated to occur in 2 per 1000 live-born term infants, and some degree of pulmonary hypertension complicates the course of >10% of all neonates with respiratory failure. This review article discusses the vascular abnormalities that are associated with neonatal pulmonary hypertension, including recognition of its role in severe bronchopulmonary dysplasia in preterm infants. A systematic review of the evidence for common therapies including inhaled nitric oxide, high-frequency ventilation, surfactant, and extracorporeal life support is included. Finally, this field is rapidly evolving, and the rationale for promising new treatment approaches is reviewed, including inhibition of phosphodiesterases and scavengers of reactive oxygen species. (Pediatr Crit Care Med 2010; 11[Suppl.]:S79 -S84).

Original languageEnglish (US)
JournalPediatric Critical Care Medicine
Volume11
Issue numberSUPPL. 2
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • High-frequency ventilation
  • Nitric oxide
  • Oxygen
  • Phosphodiesterase reactive oxygen species

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

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