@article{c1cb9f8cf75a4f7da461f0a0a52c8a97,
title = "Neighborhood disadvantage and dementia incidence in a cohort of Asian American and non-Latino White older adults in Northern California",
abstract = "Introduction: Some evidence suggests that neighborhood socioeconomic disadvantage is associated with dementia-related outcomes. However, prior research is predominantly among non-Latino Whites. Methods: We evaluated the association between neighborhood disadvantage (Area Deprivation Index [ADI]) and dementia incidence in Asian American (n = 18,103) and non-Latino White (n = 149,385) members of a Northern California integrated health care delivery system aged 60 to 89 at baseline. Race/ethnicity-specific Cox proportional hazards models adjusted for individual-level age, sex, socioeconomic measures, and block group population density estimated hazard ratios (HRs) for dementia. Results: Among non-Latino Whites, ADI was associated with dementia incidence (most vs. least disadvantaged ADI quintile HR = 1.09, 95% confidence interval [CI] = 1.02–1.15). Among Asian Americans, associations were close to null (e.g., most vs. least disadvantaged ADI quintile HR = 1.01, 95% CI = 0.85–1.21). Discussion: ADI was associated with dementia incidence among non-Latino Whites but not Asian Americans. Understanding the potentially different mechanisms driving dementia incidence in these groups could inform dementia prevention efforts.",
keywords = "dementia, incidence, neighborhood disadvantage, racial/ethnic disparities, social determinants",
author = "Mobley, {Taylor M.} and Crystal Shaw and Eleanor Hayes-Larson and Joseph Fong and Paola Gilsanz and Gee, {Gilbert C.} and Ron Brookmeyer and Whitmer, {Rachel A.} and Casey, {Joan A.} and Mayeda, {Elizabeth Rose}",
note = "Funding Information: Taylor M. Mobley, Crystal Shaw, Eleanor Hayes‐Larson, and Joseph Fong have nothing to disclose. Paola Gilsanz: NIA grant R01AG067199 (payment to institution); Alzheimer's Association/Judy Fund grant 2019‐AARGD‐644788 (payment to institution). Gilbert C. Gee: funding from other NIH grants, Lupus Foundation of America, and CDC (payment to institution); speaking honoraria from academic institutions and research societies (payment to Gilbert C. Gee); member of a Data Safety and Monitoring Board (DSMB) at Harvard Medical School. Ron Brookmeyer: other NIH grants (payments to institution); honorarium for service on Mayo Clinic Study of Aging External Advisory Committee (payment to Ron Brookmeyer). Rachel A. Whitmer: other NIH grants (payments to institution). Joan A. Casey: other NIH grants (payments to institution). Elizabeth Rose Mayeda: other NIH grants (payments to institution), Hellman Fellows Fund (payment to institution); Society for Epidemiologic Research Early Career Award honorarium (payment to Elizabeth Rose Mayeda); service on leadership committees for the Methods in Longitudinal Research on Dementia (MELODEM) and the Advanced Psychometrics Methods in Cognitive Aging Research conference (no payments made). Funding Information: We are grateful to the Kaiser Permanente Northern California members who have generously agreed to participate in the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH). Support for participant enrollment, survey completion, and biospecimen collection for the RPGEH was provided by the Robert Wood Johnson Foundation, the Wayne and Gladys Valley Foundation, the Ellison Medical Foundation, and Kaiser Permanente Community Benefit programs. We are also grateful to the Neighborhood Atlas study team for sharing ADI data with us for this analysis. This work was supported by the National Institutes of Health (grant numbers NIA R00AG053410, NIA R01AG052132, NIA R01AG066132, NIA P30AG010129, and NIA R01AG063969). Publisher Copyright: {\textcopyright} 2022 the Alzheimer's Association.",
year = "2022",
doi = "10.1002/alz.12660",
language = "English (US)",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
}