Abstract
Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 75-84 |
| Number of pages | 10 |
| Journal | HIV Medicine |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2006 |
| Externally published | Yes |
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Keywords
- Africa
- AIDS
- Children
- Coreceptor polymorphisms
- Disease progression
- Host immunogenetics
- nef gene
ASJC Scopus subject areas
- Virology
- Medicine(all)
- Immunology
Cite this
nef gene sequence variation among HIV-1-infected African children. / Chakraborty, Rana; Reinis, M.; Rostron, T.; Philpott, S.; Dong, T.; D'Agostino, A.; Musoke, R.; de Silva, E.; Stumpf, M.; Weiser, Barbara; Burger, Harold; Rowland-Jones, S. L.
In: HIV Medicine, Vol. 7, No. 2, 03.2006, p. 75-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - nef gene sequence variation among HIV-1-infected African children
AU - Chakraborty, Rana
AU - Reinis, M.
AU - Rostron, T.
AU - Philpott, S.
AU - Dong, T.
AU - D'Agostino, A.
AU - Musoke, R.
AU - de Silva, E.
AU - Stumpf, M.
AU - Weiser, Barbara
AU - Burger, Harold
AU - Rowland-Jones, S. L.
PY - 2006/3
Y1 - 2006/3
N2 - Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.
AB - Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.
KW - Africa
KW - AIDS
KW - Children
KW - Coreceptor polymorphisms
KW - Disease progression
KW - Host immunogenetics
KW - nef gene
UR - http://www.scopus.com/inward/record.url?scp=33645994804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645994804&partnerID=8YFLogxK
U2 - 10.1111/j.1468-1293.2006.00341.x
DO - 10.1111/j.1468-1293.2006.00341.x
M3 - Article
C2 - 16420252
AN - SCOPUS:33645994804
VL - 7
SP - 75
EP - 84
JO - HIV Medicine
JF - HIV Medicine
SN - 1464-2662
IS - 2
ER -