nef gene sequence variation among HIV-1-infected African children

Rana Chakraborty; M. Reinis; T. Rostron; S. Philpott; T. Dong; A. D'Agostino; R. Musoke; E. de Silva; M. Stumpf; Barbara Weiser; Harold Burger; S. L. Rowland-Jones

doi:10.1111/j.1468-1293.2006.00341.x

nef gene sequence variation among HIV-1-infected African children

Rana Chakraborty, M. Reinis, T. Rostron, S. Philpott, T. Dong, A. D'Agostino, R. Musoke, E. de Silva, M. Stumpf, Barbara Weiser, Harold Burger, S. L. Rowland-Jones

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.

Original language	English (US)
Pages (from-to)	75-84
Number of pages	10
Journal	HIV Medicine
Volume	7
Issue number	2
DOIs	https://doi.org/10.1111/j.1468-1293.2006.00341.x
State	Published - Mar 2006
Externally published	Yes

Keywords

Africa
AIDS
Children
Coreceptor polymorphisms
Disease progression
Host immunogenetics
nef gene

ASJC Scopus subject areas

Virology
Medicine(all)
Immunology

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title = "nef gene sequence variation among HIV-1-infected African children",

abstract = "Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.",

keywords = "Africa, AIDS, Children, Coreceptor polymorphisms, Disease progression, Host immunogenetics, nef gene",

author = "Rana Chakraborty and M. Reinis and T. Rostron and S. Philpott and T. Dong and A. D'Agostino and R. Musoke and {de Silva}, E. and M. Stumpf and Barbara Weiser and Harold Burger and Rowland-Jones, {S. L.}",

year = "2006",

month = mar,

doi = "10.1111/j.1468-1293.2006.00341.x",

language = "English (US)",

volume = "7",

pages = "75--84",

journal = "HIV Medicine",

issn = "1464-2662",

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TY - JOUR

T1 - nef gene sequence variation among HIV-1-infected African children

AU - Chakraborty, Rana

AU - Reinis, M.

AU - Rostron, T.

AU - Philpott, S.

AU - Dong, T.

AU - D'Agostino, A.

AU - Musoke, R.

AU - de Silva, E.

AU - Stumpf, M.

AU - Weiser, Barbara

AU - Burger, Harold

AU - Rowland-Jones, S. L.

PY - 2006/3

Y1 - 2006/3

N2 - Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.

AB - Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.

KW - Africa

KW - AIDS

KW - Children

KW - Coreceptor polymorphisms

KW - Disease progression

KW - Host immunogenetics

KW - nef gene

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DO - 10.1111/j.1468-1293.2006.00341.x

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C2 - 16420252

AN - SCOPUS:33645994804

VL - 7

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JO - HIV Medicine

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SN - 1464-2662

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ER -

nef gene sequence variation among HIV-1-infected African children

Abstract

Keywords

ASJC Scopus subject areas

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