nef gene sequence variation among HIV-1-infected African children

Rana Chakraborty, M. Reinis, T. Rostron, S. Philpott, T. Dong, A. D'Agostino, R. Musoke, E. de Silva, M. Stumpf, Barbara Weiser, Harold Burger, S. L. Rowland-Jones

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalHIV Medicine
Volume7
Issue number2
DOIs
StatePublished - Mar 2006
Externally publishedYes

Keywords

  • Africa
  • AIDS
  • Children
  • Coreceptor polymorphisms
  • Disease progression
  • Host immunogenetics
  • nef gene

ASJC Scopus subject areas

  • Virology
  • Medicine(all)
  • Immunology

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  • Cite this

    Chakraborty, R., Reinis, M., Rostron, T., Philpott, S., Dong, T., D'Agostino, A., Musoke, R., de Silva, E., Stumpf, M., Weiser, B., Burger, H., & Rowland-Jones, S. L. (2006). nef gene sequence variation among HIV-1-infected African children. HIV Medicine, 7(2), 75-84. https://doi.org/10.1111/j.1468-1293.2006.00341.x