nef gene sequence variation among HIV-1-infected African children

Rana Chakraborty, M. Reinis, T. Rostron, S. Philpott, T. Dong, A. D'Agostino, R. Musoke, E. de Silva, M. Stumpf, Barbara Weiser, Harold Burger, S. L. Rowland-Jones

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1. Methods: In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors. Results: Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression. Conclusions: Nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalHIV Medicine
Volume7
Issue number2
DOIs
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

HIV-1
Genes
Disease Progression
Immunogenetics
Genetic Polymorphisms
Infection
Proteins

Keywords

  • Africa
  • AIDS
  • Children
  • Coreceptor polymorphisms
  • Disease progression
  • Host immunogenetics
  • nef gene

ASJC Scopus subject areas

  • Virology
  • Medicine(all)
  • Immunology

Cite this

Chakraborty, R., Reinis, M., Rostron, T., Philpott, S., Dong, T., D'Agostino, A., ... Rowland-Jones, S. L. (2006). nef gene sequence variation among HIV-1-infected African children. HIV Medicine, 7(2), 75-84. https://doi.org/10.1111/j.1468-1293.2006.00341.x

nef gene sequence variation among HIV-1-infected African children. / Chakraborty, Rana; Reinis, M.; Rostron, T.; Philpott, S.; Dong, T.; D'Agostino, A.; Musoke, R.; de Silva, E.; Stumpf, M.; Weiser, Barbara; Burger, Harold; Rowland-Jones, S. L.

In: HIV Medicine, Vol. 7, No. 2, 03.2006, p. 75-84.

Research output: Contribution to journalArticle

Chakraborty, R, Reinis, M, Rostron, T, Philpott, S, Dong, T, D'Agostino, A, Musoke, R, de Silva, E, Stumpf, M, Weiser, B, Burger, H & Rowland-Jones, SL 2006, 'nef gene sequence variation among HIV-1-infected African children', HIV Medicine, vol. 7, no. 2, pp. 75-84. https://doi.org/10.1111/j.1468-1293.2006.00341.x
Chakraborty R, Reinis M, Rostron T, Philpott S, Dong T, D'Agostino A et al. nef gene sequence variation among HIV-1-infected African children. HIV Medicine. 2006 Mar;7(2):75-84. https://doi.org/10.1111/j.1468-1293.2006.00341.x
Chakraborty, Rana ; Reinis, M. ; Rostron, T. ; Philpott, S. ; Dong, T. ; D'Agostino, A. ; Musoke, R. ; de Silva, E. ; Stumpf, M. ; Weiser, Barbara ; Burger, Harold ; Rowland-Jones, S. L. / nef gene sequence variation among HIV-1-infected African children. In: HIV Medicine. 2006 ; Vol. 7, No. 2. pp. 75-84.
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AU - Musoke, R.

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