Necrotizing gastritis associated with Clostridium septicum in a rabbit

Jorge P. Garcia, Janet Moore, Panayiotis Loukopoulos, Santiago S Diab, Francisco A Uzal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Clostridium septicum is the causative agent of histotoxic infections, including malignant edema and braxy (necrotizing abomasitis) in several animal species. The carcass of a 2-year–old, female New Zealand white rabbit with a history of acute depression and obtundation followed by death was received at the California Animal Health and Food Safety Laboratory System (San Bernardino, California) for necropsy and diagnostic workup. No gross lesions were detected at necropsy. Microscopically, there was moderate to severe, multifocal fibrinonecrotizing, transmural gastritis with numerous intralesional Gram-positive, sporulated rods, and disseminated thrombosis of the brain, lungs, heart, and liver, with occasional intravascular rods. The rods observed within the gastric wall and thrombi in the stomach and lung were positive for C. septicum by immunohistochemical staining. However, this microorganism was not isolated from stomach content. Clostridium septicum should be included in the list of possible etiologies of gastritis in rabbits.

Original languageEnglish (US)
Pages (from-to)669-673
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Issue number5
StatePublished - Sep 1 2014


  • Clostridium septicum
  • gastritis
  • rabbits

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Necrotizing gastritis associated with Clostridium septicum in a rabbit'. Together they form a unique fingerprint.

Cite this