Near infrared monitoring of perfusion and oxygen availability in abdominal organs and skeletal muscle during hypoxia

Jean Michel Maarek, Sandor Vari, Laura Marcu, Thanassis Papaioanou, Vani Pergadia, Wendy Snyder, Warren Grundfest

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

Near infrared spectroscopy was used to quantify blood content and oxygenation dynamics in abdominal organs and skeletal muscle of 18 anesthetized rabbits during hypoxic hypoxia. Liver, kidney and hindlimb muscle were exposed surgically. Laser diode pulses (775, 8 10, 862 and 904 nm) transmitted across the tissues were detected by means of a photomultiplier. The amount and redox level of tissue hemoglobin were estimated from the near infrared signals and monitored during 5 mm long hypoxic challenges (10% and 6% FiO2) and subsequent recovery periods. In the kidney, exposure to 10% FiO2 resulted in rapid and symmetrical changes in oxygenated and reduced hemoglobin with 50% of the variations occurring within 1 mm and a plateau after 3 min. Total hemoglobin did not change and hemoglobin oxygenation returned to baseline within 1 mm of hypoxia cessation. Exposure to 6% FiO2 doubled the decrease in oxygenated hemoglobin and induced a sustained vasoconstriction which decreased total hemoglobin content 2 min after initiation of hypoxia. Comparable patterns were observed in the liver and skeletal muscle with the following exceptions: Local vasoconstriction was generally not observed at 6% FiO2, return to baseline oxygen availability was much slower in skeletal muscle than in the other organs.

Original languageEnglish (US)
Pages (from-to)157-165
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2135
DOIs
StatePublished - May 19 1994
EventAdvances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases 1994 - Los Angeles, United States
Duration: Jan 23 1994Jan 29 1994

Fingerprint

Hypoxia
skeletal muscle
Hemoglobin
Skeletal muscle
hypoxia
hemoglobin
muscles
organs
availability
Muscle
Oxygen
Hemoglobins
Infrared
Availability
Monitoring
Infrared radiation
oxygen
vasoconstriction
Oxygenation
oxygenation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Near infrared monitoring of perfusion and oxygen availability in abdominal organs and skeletal muscle during hypoxia. / Maarek, Jean Michel; Vari, Sandor; Marcu, Laura; Papaioanou, Thanassis; Pergadia, Vani; Snyder, Wendy; Grundfest, Warren.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 2135, 19.05.1994, p. 157-165.

Research output: Contribution to journalConference article

Maarek, Jean Michel ; Vari, Sandor ; Marcu, Laura ; Papaioanou, Thanassis ; Pergadia, Vani ; Snyder, Wendy ; Grundfest, Warren. / Near infrared monitoring of perfusion and oxygen availability in abdominal organs and skeletal muscle during hypoxia. In: Proceedings of SPIE - The International Society for Optical Engineering. 1994 ; Vol. 2135. pp. 157-165.
@article{7a73540bb07c4580b870b858c7969be5,
title = "Near infrared monitoring of perfusion and oxygen availability in abdominal organs and skeletal muscle during hypoxia",
abstract = "Near infrared spectroscopy was used to quantify blood content and oxygenation dynamics in abdominal organs and skeletal muscle of 18 anesthetized rabbits during hypoxic hypoxia. Liver, kidney and hindlimb muscle were exposed surgically. Laser diode pulses (775, 8 10, 862 and 904 nm) transmitted across the tissues were detected by means of a photomultiplier. The amount and redox level of tissue hemoglobin were estimated from the near infrared signals and monitored during 5 mm long hypoxic challenges (10{\%} and 6{\%} FiO2) and subsequent recovery periods. In the kidney, exposure to 10{\%} FiO2 resulted in rapid and symmetrical changes in oxygenated and reduced hemoglobin with 50{\%} of the variations occurring within 1 mm and a plateau after 3 min. Total hemoglobin did not change and hemoglobin oxygenation returned to baseline within 1 mm of hypoxia cessation. Exposure to 6{\%} FiO2 doubled the decrease in oxygenated hemoglobin and induced a sustained vasoconstriction which decreased total hemoglobin content 2 min after initiation of hypoxia. Comparable patterns were observed in the liver and skeletal muscle with the following exceptions: Local vasoconstriction was generally not observed at 6{\%} FiO2, return to baseline oxygen availability was much slower in skeletal muscle than in the other organs.",
author = "Maarek, {Jean Michel} and Sandor Vari and Laura Marcu and Thanassis Papaioanou and Vani Pergadia and Wendy Snyder and Warren Grundfest",
year = "1994",
month = "5",
day = "19",
doi = "10.1117/12.175989",
language = "English (US)",
volume = "2135",
pages = "157--165",
journal = "Proceedings of SPIE - The International Society for Optical Engineering",
issn = "0277-786X",
publisher = "SPIE",

}

TY - JOUR

T1 - Near infrared monitoring of perfusion and oxygen availability in abdominal organs and skeletal muscle during hypoxia

AU - Maarek, Jean Michel

AU - Vari, Sandor

AU - Marcu, Laura

AU - Papaioanou, Thanassis

AU - Pergadia, Vani

AU - Snyder, Wendy

AU - Grundfest, Warren

PY - 1994/5/19

Y1 - 1994/5/19

N2 - Near infrared spectroscopy was used to quantify blood content and oxygenation dynamics in abdominal organs and skeletal muscle of 18 anesthetized rabbits during hypoxic hypoxia. Liver, kidney and hindlimb muscle were exposed surgically. Laser diode pulses (775, 8 10, 862 and 904 nm) transmitted across the tissues were detected by means of a photomultiplier. The amount and redox level of tissue hemoglobin were estimated from the near infrared signals and monitored during 5 mm long hypoxic challenges (10% and 6% FiO2) and subsequent recovery periods. In the kidney, exposure to 10% FiO2 resulted in rapid and symmetrical changes in oxygenated and reduced hemoglobin with 50% of the variations occurring within 1 mm and a plateau after 3 min. Total hemoglobin did not change and hemoglobin oxygenation returned to baseline within 1 mm of hypoxia cessation. Exposure to 6% FiO2 doubled the decrease in oxygenated hemoglobin and induced a sustained vasoconstriction which decreased total hemoglobin content 2 min after initiation of hypoxia. Comparable patterns were observed in the liver and skeletal muscle with the following exceptions: Local vasoconstriction was generally not observed at 6% FiO2, return to baseline oxygen availability was much slower in skeletal muscle than in the other organs.

AB - Near infrared spectroscopy was used to quantify blood content and oxygenation dynamics in abdominal organs and skeletal muscle of 18 anesthetized rabbits during hypoxic hypoxia. Liver, kidney and hindlimb muscle were exposed surgically. Laser diode pulses (775, 8 10, 862 and 904 nm) transmitted across the tissues were detected by means of a photomultiplier. The amount and redox level of tissue hemoglobin were estimated from the near infrared signals and monitored during 5 mm long hypoxic challenges (10% and 6% FiO2) and subsequent recovery periods. In the kidney, exposure to 10% FiO2 resulted in rapid and symmetrical changes in oxygenated and reduced hemoglobin with 50% of the variations occurring within 1 mm and a plateau after 3 min. Total hemoglobin did not change and hemoglobin oxygenation returned to baseline within 1 mm of hypoxia cessation. Exposure to 6% FiO2 doubled the decrease in oxygenated hemoglobin and induced a sustained vasoconstriction which decreased total hemoglobin content 2 min after initiation of hypoxia. Comparable patterns were observed in the liver and skeletal muscle with the following exceptions: Local vasoconstriction was generally not observed at 6% FiO2, return to baseline oxygen availability was much slower in skeletal muscle than in the other organs.

UR - http://www.scopus.com/inward/record.url?scp=85029390742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029390742&partnerID=8YFLogxK

U2 - 10.1117/12.175989

DO - 10.1117/12.175989

M3 - Conference article

AN - SCOPUS:85029390742

VL - 2135

SP - 157

EP - 165

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

SN - 0277-786X

ER -