Near infrared monitoring of hemoglobin content in the kidney during ischemia

Wendy J. Snyder, Jean Michel Maarek, Sandor O. Van, Laura Marcu, Thanassis Papaioannou, Vani R. Pergadia, Warren S. Grundfest

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Near infrared spectroscopy was used to monitor changes in hemoglobin concentration in the kidney of 9 anesthetized rabbits during ischemic conditions. Laser diodes (775,810, 862, and 904 nm) were placed on the surface of the kidney, the transmitted light was detected by a photomultiplier. Three stages of ischemia were induced in the kidney by occluding the abdominal aorta at approximately 1/3, 2/3 and total occlusion. Hemoglobin content was monitored during 10 minutes of occlusion followed by 10 minutes of recovery. The occlusions resulted in an average decrease in blood pressure of 36%, 53%,and 100% in the abdominal aorta. The partial occlusions resulted in an increasing trend in total hemoglobin content during the 10 minute occlusion followed by a return to baseline hemoglobin concentration. Within the first 30 seconds of the total occlusion maneuver, an immediate decrease in hemoglobin content was observed. During the occlusion the hemoglobin content increased slowly, corresponding to an increase in reduced hemoglobin content. Oxygenated hemoglobin content remained constant during the occlusion and increased immediately when the occlusion was released.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Apr 12 1995
Externally publishedYes
EventAdvances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II 1995 - San Jose, United States
Duration: Feb 1 1995Feb 28 1995


  • Kidney Ischemia
  • Laser Diodes
  • Near-Infrared Spectroscopy
  • Vasoconstriction
  • Vasodilation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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