Naturally occurring vitreous chamber-based myopia in the labrador retriever

Donald O. Mutti, Karla Zadnik, Christopher J Murphy

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

PURPOSE. To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS. Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature were measured in the right eyes of 57 of these dogs using a video-based keratophakometer, with axial ocular dimensions measured using A-scan ultrasonography. RESULTS. Of the 75 dogs tested, 11 (14.7%) were myopic by at least -0.50 D in one eye, and 6 (8.0%) were myopic in both eyes (full range of refractive errors, + 3.50 D to -5.00 D). Of the 57 dogs with ocular component measurements, seven (12.3%) were myopic by at least 0.50 D in the right eye. There was a significant negative correlation between refractive error and vitreous chamber depth (Spearman r = -0.42; P < 0.001). Myopic eyes had an elongated vitreous chamber depth (10.87, ± 0.34 mm for myopic dogs, 10.02 ± 0.40 mm for nonmyopic dogs; P < 0.0001, Kruskal-Wallis test). There was also a significant quadratic association between lens thickness and vitreous chamber depth (P < 0.005; R2 = 0.11), indicating that thinner lenses occurred at both shorter and longer vitreous chamber depths. CONCLUSIONS. Myopia in the Labrador retriever is analogous to human myopia in that it is caused by an elongated vitreous chamber. Thinner crystalline lenses found at longer vitreous chamber depths may be analogous to lens thinning documented in human ocular development. The Labrador retriever warrants investigation as a potential model of myopia that is naturally occurring rather than experimentally induced.

Original languageEnglish (US)
Pages (from-to)1577-1584
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume40
Issue number7
StatePublished - 1999
Externally publishedYes

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Newfoundland and Labrador
Myopia
Refractive Errors
Dogs
Lenses
Crystalline Lens
Retinoscopy
Mydriatics
Human Development
Ultrasonography

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Naturally occurring vitreous chamber-based myopia in the labrador retriever. / Mutti, Donald O.; Zadnik, Karla; Murphy, Christopher J.

In: Investigative Ophthalmology and Visual Science, Vol. 40, No. 7, 1999, p. 1577-1584.

Research output: Contribution to journalArticle

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title = "Naturally occurring vitreous chamber-based myopia in the labrador retriever",
abstract = "PURPOSE. To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS. Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature were measured in the right eyes of 57 of these dogs using a video-based keratophakometer, with axial ocular dimensions measured using A-scan ultrasonography. RESULTS. Of the 75 dogs tested, 11 (14.7{\%}) were myopic by at least -0.50 D in one eye, and 6 (8.0{\%}) were myopic in both eyes (full range of refractive errors, + 3.50 D to -5.00 D). Of the 57 dogs with ocular component measurements, seven (12.3{\%}) were myopic by at least 0.50 D in the right eye. There was a significant negative correlation between refractive error and vitreous chamber depth (Spearman r = -0.42; P < 0.001). Myopic eyes had an elongated vitreous chamber depth (10.87, ± 0.34 mm for myopic dogs, 10.02 ± 0.40 mm for nonmyopic dogs; P < 0.0001, Kruskal-Wallis test). There was also a significant quadratic association between lens thickness and vitreous chamber depth (P < 0.005; R2 = 0.11), indicating that thinner lenses occurred at both shorter and longer vitreous chamber depths. CONCLUSIONS. Myopia in the Labrador retriever is analogous to human myopia in that it is caused by an elongated vitreous chamber. Thinner crystalline lenses found at longer vitreous chamber depths may be analogous to lens thinning documented in human ocular development. The Labrador retriever warrants investigation as a potential model of myopia that is naturally occurring rather than experimentally induced.",
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AU - Mutti, Donald O.

AU - Zadnik, Karla

AU - Murphy, Christopher J

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N2 - PURPOSE. To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS. Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature were measured in the right eyes of 57 of these dogs using a video-based keratophakometer, with axial ocular dimensions measured using A-scan ultrasonography. RESULTS. Of the 75 dogs tested, 11 (14.7%) were myopic by at least -0.50 D in one eye, and 6 (8.0%) were myopic in both eyes (full range of refractive errors, + 3.50 D to -5.00 D). Of the 57 dogs with ocular component measurements, seven (12.3%) were myopic by at least 0.50 D in the right eye. There was a significant negative correlation between refractive error and vitreous chamber depth (Spearman r = -0.42; P < 0.001). Myopic eyes had an elongated vitreous chamber depth (10.87, ± 0.34 mm for myopic dogs, 10.02 ± 0.40 mm for nonmyopic dogs; P < 0.0001, Kruskal-Wallis test). There was also a significant quadratic association between lens thickness and vitreous chamber depth (P < 0.005; R2 = 0.11), indicating that thinner lenses occurred at both shorter and longer vitreous chamber depths. CONCLUSIONS. Myopia in the Labrador retriever is analogous to human myopia in that it is caused by an elongated vitreous chamber. Thinner crystalline lenses found at longer vitreous chamber depths may be analogous to lens thinning documented in human ocular development. The Labrador retriever warrants investigation as a potential model of myopia that is naturally occurring rather than experimentally induced.

AB - PURPOSE. To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS. Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature were measured in the right eyes of 57 of these dogs using a video-based keratophakometer, with axial ocular dimensions measured using A-scan ultrasonography. RESULTS. Of the 75 dogs tested, 11 (14.7%) were myopic by at least -0.50 D in one eye, and 6 (8.0%) were myopic in both eyes (full range of refractive errors, + 3.50 D to -5.00 D). Of the 57 dogs with ocular component measurements, seven (12.3%) were myopic by at least 0.50 D in the right eye. There was a significant negative correlation between refractive error and vitreous chamber depth (Spearman r = -0.42; P < 0.001). Myopic eyes had an elongated vitreous chamber depth (10.87, ± 0.34 mm for myopic dogs, 10.02 ± 0.40 mm for nonmyopic dogs; P < 0.0001, Kruskal-Wallis test). There was also a significant quadratic association between lens thickness and vitreous chamber depth (P < 0.005; R2 = 0.11), indicating that thinner lenses occurred at both shorter and longer vitreous chamber depths. CONCLUSIONS. Myopia in the Labrador retriever is analogous to human myopia in that it is caused by an elongated vitreous chamber. Thinner crystalline lenses found at longer vitreous chamber depths may be analogous to lens thinning documented in human ocular development. The Labrador retriever warrants investigation as a potential model of myopia that is naturally occurring rather than experimentally induced.

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