Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat

Mark D Kittleson, P. R. Fox, C. Basso, G. Thiene

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A definitively diagnosed case of left ventricular noncompaction (LVNC) has not been previously reported in a non-human species. We describe a Maine Coon cross cat with echocardiographically and pathologically documented LVNC. The cat was from a research colony and was heterozygous for the cardiac myosin binding protein C mutation associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats (A31P). The cat had had echocardiographic examinations performed every 6 months until 6 years of age at which time the cat died of an unrelated cause. Echocardiographic findings consistent with LVNC (moth-eaten appearance to the inner wall of the mid- to apical region of the left ventricle (LV) in cross section and trabeculations of the inner LV wall that communicated with the LV chamber) first were identified at 2 years of age. At necropsy, pathologic findings of LVNC were verified and included the presence of noncompacted myocardium that consisted of endothelial-lined trabeculations and sinusoids that constituted more than half of the inner part of the LV wall. The right ventricular (RV) wall also was affected. Histopathology identified myofiber disarray, which is characteristic of HCM, although heart weight was normal and LV wall thickness was not increased.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalJournal of Veterinary Internal Medicine
Volume31
Issue number2
DOIs
StatePublished - Mar 1 2017

Fingerprint

Heart Ventricles
Cats
cats
Hypertrophic Cardiomyopathy
cardiomyopathy
Cardiac Myosins
Moths
myosin
myocardium
histopathology
moths
binding proteins
necropsy
Myocardium
heart
mutation
Weights and Measures
Mutation
Research
Maine coon

Keywords

  • Cardiomyopathy
  • Echocardiography
  • Feline
  • Hypertrabeculation
  • Left Ventricle
  • Noncompaction

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat. / Kittleson, Mark D; Fox, P. R.; Basso, C.; Thiene, G.

In: Journal of Veterinary Internal Medicine, Vol. 31, No. 2, 01.03.2017, p. 527-531.

Research output: Contribution to journalArticle

@article{52ced7b846ca4728a74861fe4591d55e,
title = "Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat",
abstract = "A definitively diagnosed case of left ventricular noncompaction (LVNC) has not been previously reported in a non-human species. We describe a Maine Coon cross cat with echocardiographically and pathologically documented LVNC. The cat was from a research colony and was heterozygous for the cardiac myosin binding protein C mutation associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats (A31P). The cat had had echocardiographic examinations performed every 6 months until 6 years of age at which time the cat died of an unrelated cause. Echocardiographic findings consistent with LVNC (moth-eaten appearance to the inner wall of the mid- to apical region of the left ventricle (LV) in cross section and trabeculations of the inner LV wall that communicated with the LV chamber) first were identified at 2 years of age. At necropsy, pathologic findings of LVNC were verified and included the presence of noncompacted myocardium that consisted of endothelial-lined trabeculations and sinusoids that constituted more than half of the inner part of the LV wall. The right ventricular (RV) wall also was affected. Histopathology identified myofiber disarray, which is characteristic of HCM, although heart weight was normal and LV wall thickness was not increased.",
keywords = "Cardiomyopathy, Echocardiography, Feline, Hypertrabeculation, Left Ventricle, Noncompaction",
author = "Kittleson, {Mark D} and Fox, {P. R.} and C. Basso and G. Thiene",
year = "2017",
month = "3",
day = "1",
doi = "10.1111/jvim.14663",
language = "English (US)",
volume = "31",
pages = "527--531",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat

AU - Kittleson, Mark D

AU - Fox, P. R.

AU - Basso, C.

AU - Thiene, G.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - A definitively diagnosed case of left ventricular noncompaction (LVNC) has not been previously reported in a non-human species. We describe a Maine Coon cross cat with echocardiographically and pathologically documented LVNC. The cat was from a research colony and was heterozygous for the cardiac myosin binding protein C mutation associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats (A31P). The cat had had echocardiographic examinations performed every 6 months until 6 years of age at which time the cat died of an unrelated cause. Echocardiographic findings consistent with LVNC (moth-eaten appearance to the inner wall of the mid- to apical region of the left ventricle (LV) in cross section and trabeculations of the inner LV wall that communicated with the LV chamber) first were identified at 2 years of age. At necropsy, pathologic findings of LVNC were verified and included the presence of noncompacted myocardium that consisted of endothelial-lined trabeculations and sinusoids that constituted more than half of the inner part of the LV wall. The right ventricular (RV) wall also was affected. Histopathology identified myofiber disarray, which is characteristic of HCM, although heart weight was normal and LV wall thickness was not increased.

AB - A definitively diagnosed case of left ventricular noncompaction (LVNC) has not been previously reported in a non-human species. We describe a Maine Coon cross cat with echocardiographically and pathologically documented LVNC. The cat was from a research colony and was heterozygous for the cardiac myosin binding protein C mutation associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats (A31P). The cat had had echocardiographic examinations performed every 6 months until 6 years of age at which time the cat died of an unrelated cause. Echocardiographic findings consistent with LVNC (moth-eaten appearance to the inner wall of the mid- to apical region of the left ventricle (LV) in cross section and trabeculations of the inner LV wall that communicated with the LV chamber) first were identified at 2 years of age. At necropsy, pathologic findings of LVNC were verified and included the presence of noncompacted myocardium that consisted of endothelial-lined trabeculations and sinusoids that constituted more than half of the inner part of the LV wall. The right ventricular (RV) wall also was affected. Histopathology identified myofiber disarray, which is characteristic of HCM, although heart weight was normal and LV wall thickness was not increased.

KW - Cardiomyopathy

KW - Echocardiography

KW - Feline

KW - Hypertrabeculation

KW - Left Ventricle

KW - Noncompaction

UR - http://www.scopus.com/inward/record.url?scp=85013213175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013213175&partnerID=8YFLogxK

U2 - 10.1111/jvim.14663

DO - 10.1111/jvim.14663

M3 - Article

C2 - 28158907

AN - SCOPUS:85013213175

VL - 31

SP - 527

EP - 531

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 2

ER -