Natural killer cell development and maturation in aged mice

Eleni Beli, David M. Duriancik, Jonathan F. Clinthorne, Taehyung Lee, Sung Jin Kim, Elizabeth M. Gardner

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effect of aging on natural killer cell homeostasis is not well studied in humans or in animal models. We compared natural killer (NK) cells from young and aged mice to investigate age-related defects in NK cell distribution and development. Our findings indicate aged mice have reduced NK cells in most peripheral tissues, but not in bone marrow. Reduction of NK cells in periphery was attributed to a reduction of the most mature CD11b+ CD27- NK cells. Apoptosis was not found to explain this specific reduction of mature NK cells. Analysis of NK cell development in bone marrow revealed that aged NK cells progress normally through early stages of development, but a smaller percentage of aged NK cells achieved terminal maturation. Less mature NK cells in aged bone marrow correlated with reduced proliferation of immature NK cells. We propose that advanced age impairs bone marrow maturation of NK cells, possibly affecting homeostasis of NK cells in peripheral tissues. These alterations in NK cell maturational status have critical consequences for NK cell function in advanced age: reduction of the mature circulating NK cells in peripheral tissues of aged mice affects their overall capacity to patrol and eliminate cancerous and viral infected cells.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalMechanisms of Ageing and Development
Volume135
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

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Natural Killer Cells
Bone Marrow
Homeostasis

Keywords

  • Aging
  • Development
  • Maturation
  • Mouse
  • Natural killer cells

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Cite this

Beli, E., Duriancik, D. M., Clinthorne, J. F., Lee, T., Kim, S. J., & Gardner, E. M. (2014). Natural killer cell development and maturation in aged mice. Mechanisms of Ageing and Development, 135(1), 33-40. https://doi.org/10.1016/j.mad.2013.11.007

Natural killer cell development and maturation in aged mice. / Beli, Eleni; Duriancik, David M.; Clinthorne, Jonathan F.; Lee, Taehyung; Kim, Sung Jin; Gardner, Elizabeth M.

In: Mechanisms of Ageing and Development, Vol. 135, No. 1, 01.2014, p. 33-40.

Research output: Contribution to journalArticle

Beli, E, Duriancik, DM, Clinthorne, JF, Lee, T, Kim, SJ & Gardner, EM 2014, 'Natural killer cell development and maturation in aged mice', Mechanisms of Ageing and Development, vol. 135, no. 1, pp. 33-40. https://doi.org/10.1016/j.mad.2013.11.007
Beli, Eleni ; Duriancik, David M. ; Clinthorne, Jonathan F. ; Lee, Taehyung ; Kim, Sung Jin ; Gardner, Elizabeth M. / Natural killer cell development and maturation in aged mice. In: Mechanisms of Ageing and Development. 2014 ; Vol. 135, No. 1. pp. 33-40.
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