Natural history of mild cognitive impairment in older persons

D. A. Bennett, R. S. Wilson, J. A. Schneider, D. A. Evans, Laurel A Beckett, N. T. Aggarwal, L. L. Barnes, J. H. Fox, J. Bach

Research output: Contribution to journalArticle

678 Citations (Scopus)

Abstract

Background: Cognitive abilities of older persons range from normal, to mild cognitive impairment, to dementia. Few large longitudinal studies have compared the natural history of mild cognitive impairment with similar persons without cognitive impairment. Methods: Participants were older Catholic clergy without dementia, 211 with mild cognitive impairment and 587 without cognitive impairment, who underwent annual clinical evaluation for AD and an assessment of different cognitive abilities. Cognitive performance tests were summarized to yield a composite measure of global cognitive function and separate summary measures of episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability. The authors compared the risk of death, risk of incident AD, and rates of change in global cognition and different cognitive domains among persons with mild cognitive impairment to those without cognitive impairment. All models controlled for age, sex, and education. Results: On average, persons with mild cognitive impairment had significantly lower scores at baseline in all cognitive domains. Over an average of 4.5 years of follow-up, 30% of persons with mild cognitive impairment died, a rate 1.7 times higher than those without cognitive impairment (95% CI, 1.2 to 2.5). In addition, 64 (34%) persons with mild cognitive impairment developed AD, a rate 3.1 times higher than those without cognitive impairment (95% CI, 2.1 to 4.5). Finally, persons with mild cognitive impairment declined significantly faster on measures of episodic memory, semantic memory, and perceptual speed, but not on measures of working memory or visuospatial ability, as compared with persons without cognitive impairment. Conclusions: Mild cognitive impairment is associated with an increased risk of death and incident AD, and a greater rate of decline in selected cognitive abilities.

Original languageEnglish (US)
Pages (from-to)198-205
Number of pages8
JournalNeurology
Volume59
Issue number2
StatePublished - Jul 23 2002

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Aptitude
Episodic Memory
Cognitive Dysfunction
Short-Term Memory
Semantics
Cognition
Dementia
Clergy
Sex Education
Longitudinal Studies
Reference Values

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bennett, D. A., Wilson, R. S., Schneider, J. A., Evans, D. A., Beckett, L. A., Aggarwal, N. T., ... Bach, J. (2002). Natural history of mild cognitive impairment in older persons. Neurology, 59(2), 198-205.

Natural history of mild cognitive impairment in older persons. / Bennett, D. A.; Wilson, R. S.; Schneider, J. A.; Evans, D. A.; Beckett, Laurel A; Aggarwal, N. T.; Barnes, L. L.; Fox, J. H.; Bach, J.

In: Neurology, Vol. 59, No. 2, 23.07.2002, p. 198-205.

Research output: Contribution to journalArticle

Bennett, DA, Wilson, RS, Schneider, JA, Evans, DA, Beckett, LA, Aggarwal, NT, Barnes, LL, Fox, JH & Bach, J 2002, 'Natural history of mild cognitive impairment in older persons', Neurology, vol. 59, no. 2, pp. 198-205.
Bennett DA, Wilson RS, Schneider JA, Evans DA, Beckett LA, Aggarwal NT et al. Natural history of mild cognitive impairment in older persons. Neurology. 2002 Jul 23;59(2):198-205.
Bennett, D. A. ; Wilson, R. S. ; Schneider, J. A. ; Evans, D. A. ; Beckett, Laurel A ; Aggarwal, N. T. ; Barnes, L. L. ; Fox, J. H. ; Bach, J. / Natural history of mild cognitive impairment in older persons. In: Neurology. 2002 ; Vol. 59, No. 2. pp. 198-205.
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