Natural History of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: A Prospective Study

K. M. Meurs, Joshua A Stern, Y. Reina-Doreste, A. W. Spier, S. L. Koplitz, R. D. Baumwart

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background: Boxer arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease that may result in sudden death or heart failure. Hypothesis/objectives: To prospectively study the natural history of Boxer ARVC. Animals: 72 dogs (49 ARVC, 23 controls). Methods: Boxers >1 year of age were recruited for annual reevaluation. Controls were defined as being ≥6 years of age and having <50 ventricular premature complex (VPCs)/24 h. ARVC was defined as ≥300 VPCs/24 h in the absence of other disease. Dogs were genotyped for the striatin deletion when possible. Descriptive statistics were determined for age; VPC number; annual change in VPC number; and left ventricular (LV) echocardiographic dimensions. Survival time was calculated. Results: Controls: median age of 7 years (range, 6-10); number of VPCs 12 (range, 4-32). Median time in study of 6 years (range, 2-9). Seventeen of 23 were genotyped (5 positive, 12 negative). ARVC: median age of diagnosis of 6 (range, 1-11). Median time in study 5 years (range, 3-8). A total of 33% were syncopal and 43/49 were genotyped (36 positive, 7 negative). Yearly change in VPCs was 46 (range, -7,699 to 33,524). Annual percentage change in LV dimensions was 0, and change in fractional shortening (FS%) was 2%. Two dogs had FS% <20%. Although ARVC dogs died suddenly, there was no difference in survival time between groups. ARVC median age of survival was 11 years, and for controls was 10 years. Conclusions/Clinical Importance: Arrhythmogenic right ventricular cardiomyopathy is a disease of middle age and frequently is associated with the striatin deletion. Syncope occurs in approximately 1/3 of affected dogs; systolic dysfunction is uncommon. The prognosis in many affected dogs is good.

Original languageEnglish (US)
Pages (from-to)1214-1220
Number of pages7
JournalJournal of Veterinary Internal Medicine
Volume28
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Boxer
  • Holter
  • Striatin
  • Sudden death
  • Ventricular premature complex

ASJC Scopus subject areas

  • veterinary(all)

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