Native American gene continuity to the modern admixed population from the Colombian Andes: Implication for biomedical, population and forensic studies

on behalf of the CHIBCHA Consortium

Research output: Contribution to journalArticle

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Abstract

Andean populations have variable degrees of Native American and European ancestry, representing an opportunity to study admixture dynamics in the populations from Latin America (also known as Hispanics). We characterized the genetic structure of two indigenous (Nasa and Pijao) and three admixed (Ibagué, Ortega and Planadas) groups from Tolima, in the Colombian Andes. DNA samples from 348 individuals were genotyped for six mitochondrial DNA (mtDNA), seven non-recombining Y-chromosome (NRY) region and 100 autosomal ancestry informative markers. Nasa and Pijao had a predominant Native American ancestry at the autosomal (92%), maternal (97%) and paternal (70%) level. The admixed groups had a predominant Native American mtDNA ancestry (90%), a substantial frequency of European NRY haplotypes (72%) and similar autosomal contributions from Europeans (51%) and Amerindians (45%). Pijao and nearby Ortega were indistinguishable at the mtDNA and autosomal level, suggesting a genetic continuity between them. Comparisons with multiple Native American populations throughout the Americas revealed that Pijao, had close similarities with Carib-speakers from distant parts of the continent, suggesting an ancient correlation between language and genes. In summary, our study aimed to understand Hispanic patterns of migration, settlement and admixture, supporting an extensive contribution of local Amerindian women to the gene pool of admixed groups and consistent with previous reports of European-male driven admixture in Colombia.

Original languageEnglish (US)
JournalForensic Science International: Genetics
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

North American Indians
Mitochondrial DNA
Y Chromosome
Hispanic Americans
Population
Genes
Gene Pool
Colombia
Latin America
Genetic Structures
Population Dynamics
Haplotypes
Language
Mothers
DNA

Keywords

  • Admixture
  • Colombia
  • Genetic structure
  • Mitochondrial DNA
  • Y-Chromosome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics

Cite this

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title = "Native American gene continuity to the modern admixed population from the Colombian Andes: Implication for biomedical, population and forensic studies",
abstract = "Andean populations have variable degrees of Native American and European ancestry, representing an opportunity to study admixture dynamics in the populations from Latin America (also known as Hispanics). We characterized the genetic structure of two indigenous (Nasa and Pijao) and three admixed (Ibagu{\'e}, Ortega and Planadas) groups from Tolima, in the Colombian Andes. DNA samples from 348 individuals were genotyped for six mitochondrial DNA (mtDNA), seven non-recombining Y-chromosome (NRY) region and 100 autosomal ancestry informative markers. Nasa and Pijao had a predominant Native American ancestry at the autosomal (92{\%}), maternal (97{\%}) and paternal (70{\%}) level. The admixed groups had a predominant Native American mtDNA ancestry (90{\%}), a substantial frequency of European NRY haplotypes (72{\%}) and similar autosomal contributions from Europeans (51{\%}) and Amerindians (45{\%}). Pijao and nearby Ortega were indistinguishable at the mtDNA and autosomal level, suggesting a genetic continuity between them. Comparisons with multiple Native American populations throughout the Americas revealed that Pijao, had close similarities with Carib-speakers from distant parts of the continent, suggesting an ancient correlation between language and genes. In summary, our study aimed to understand Hispanic patterns of migration, settlement and admixture, supporting an extensive contribution of local Amerindian women to the gene pool of admixed groups and consistent with previous reports of European-male driven admixture in Colombia.",
keywords = "Admixture, Colombia, Genetic structure, Mitochondrial DNA, Y-Chromosome",
author = "{on behalf of the CHIBCHA Consortium} and Criollo-Rayo, {Angel A.} and Mabel Boh{\'o}rquez and Rodrigo Prieto and Kimberley Howarth and Cesar Culma and Angel Carracedo and Ian Tomlinson and {Echeverry de Polnaco}, {Maria M.} and Luis Carvajal-Carmona",
year = "2018",
month = "1",
day = "1",
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language = "English (US)",
journal = "Forensic Science International: Genetics",
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TY - JOUR

T1 - Native American gene continuity to the modern admixed population from the Colombian Andes

T2 - Implication for biomedical, population and forensic studies

AU - on behalf of the CHIBCHA Consortium

AU - Criollo-Rayo, Angel A.

AU - Bohórquez, Mabel

AU - Prieto, Rodrigo

AU - Howarth, Kimberley

AU - Culma, Cesar

AU - Carracedo, Angel

AU - Tomlinson, Ian

AU - Echeverry de Polnaco, Maria M.

AU - Carvajal-Carmona, Luis

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Andean populations have variable degrees of Native American and European ancestry, representing an opportunity to study admixture dynamics in the populations from Latin America (also known as Hispanics). We characterized the genetic structure of two indigenous (Nasa and Pijao) and three admixed (Ibagué, Ortega and Planadas) groups from Tolima, in the Colombian Andes. DNA samples from 348 individuals were genotyped for six mitochondrial DNA (mtDNA), seven non-recombining Y-chromosome (NRY) region and 100 autosomal ancestry informative markers. Nasa and Pijao had a predominant Native American ancestry at the autosomal (92%), maternal (97%) and paternal (70%) level. The admixed groups had a predominant Native American mtDNA ancestry (90%), a substantial frequency of European NRY haplotypes (72%) and similar autosomal contributions from Europeans (51%) and Amerindians (45%). Pijao and nearby Ortega were indistinguishable at the mtDNA and autosomal level, suggesting a genetic continuity between them. Comparisons with multiple Native American populations throughout the Americas revealed that Pijao, had close similarities with Carib-speakers from distant parts of the continent, suggesting an ancient correlation between language and genes. In summary, our study aimed to understand Hispanic patterns of migration, settlement and admixture, supporting an extensive contribution of local Amerindian women to the gene pool of admixed groups and consistent with previous reports of European-male driven admixture in Colombia.

AB - Andean populations have variable degrees of Native American and European ancestry, representing an opportunity to study admixture dynamics in the populations from Latin America (also known as Hispanics). We characterized the genetic structure of two indigenous (Nasa and Pijao) and three admixed (Ibagué, Ortega and Planadas) groups from Tolima, in the Colombian Andes. DNA samples from 348 individuals were genotyped for six mitochondrial DNA (mtDNA), seven non-recombining Y-chromosome (NRY) region and 100 autosomal ancestry informative markers. Nasa and Pijao had a predominant Native American ancestry at the autosomal (92%), maternal (97%) and paternal (70%) level. The admixed groups had a predominant Native American mtDNA ancestry (90%), a substantial frequency of European NRY haplotypes (72%) and similar autosomal contributions from Europeans (51%) and Amerindians (45%). Pijao and nearby Ortega were indistinguishable at the mtDNA and autosomal level, suggesting a genetic continuity between them. Comparisons with multiple Native American populations throughout the Americas revealed that Pijao, had close similarities with Carib-speakers from distant parts of the continent, suggesting an ancient correlation between language and genes. In summary, our study aimed to understand Hispanic patterns of migration, settlement and admixture, supporting an extensive contribution of local Amerindian women to the gene pool of admixed groups and consistent with previous reports of European-male driven admixture in Colombia.

KW - Admixture

KW - Colombia

KW - Genetic structure

KW - Mitochondrial DNA

KW - Y-Chromosome

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JF - Forensic Science International: Genetics

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