Abstract
Andean populations have variable degrees of Native American and European ancestry, representing an opportunity to study admixture dynamics in the populations from Latin America (also known as Hispanics). We characterized the genetic structure of two indigenous (Nasa and Pijao) and three admixed (Ibagué, Ortega and Planadas) groups from Tolima, in the Colombian Andes. DNA samples from 348 individuals were genotyped for six mitochondrial DNA (mtDNA), seven non-recombining Y-chromosome (NRY) region and 100 autosomal ancestry informative markers. Nasa and Pijao had a predominant Native American ancestry at the autosomal (92%), maternal (97%) and paternal (70%) level. The admixed groups had a predominant Native American mtDNA ancestry (90%), a substantial frequency of European NRY haplotypes (72%) and similar autosomal contributions from Europeans (51%) and Amerindians (45%). Pijao and nearby Ortega were indistinguishable at the mtDNA and autosomal level, suggesting a genetic continuity between them. Comparisons with multiple Native American populations throughout the Americas revealed that Pijao, had close similarities with Carib-speakers from distant parts of the continent, suggesting an ancient correlation between language and genes. In summary, our study aimed to understand Hispanic patterns of migration, settlement and admixture, supporting an extensive contribution of local Amerindian women to the gene pool of admixed groups and consistent with previous reports of European-male driven admixture in Colombia.
| Original language | English (US) |
|---|---|
| Journal | Forensic Science International: Genetics |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Admixture
- Colombia
- Genetic structure
- Mitochondrial DNA
- Y-Chromosome
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Genetics
Cite this
Native American gene continuity to the modern admixed population from the Colombian Andes : Implication for biomedical, population and forensic studies. / on behalf of the CHIBCHA Consortium.
In: Forensic Science International: Genetics, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Native American gene continuity to the modern admixed population from the Colombian Andes
T2 - Implication for biomedical, population and forensic studies
AU - on behalf of the CHIBCHA Consortium
AU - Criollo-Rayo, Angel A.
AU - Bohórquez, Mabel
AU - Prieto, Rodrigo
AU - Howarth, Kimberley
AU - Culma, Cesar
AU - Carracedo, Angel
AU - Tomlinson, Ian
AU - Echeverry de Polnaco, Maria M.
AU - Carvajal-Carmona, Luis
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Andean populations have variable degrees of Native American and European ancestry, representing an opportunity to study admixture dynamics in the populations from Latin America (also known as Hispanics). We characterized the genetic structure of two indigenous (Nasa and Pijao) and three admixed (Ibagué, Ortega and Planadas) groups from Tolima, in the Colombian Andes. DNA samples from 348 individuals were genotyped for six mitochondrial DNA (mtDNA), seven non-recombining Y-chromosome (NRY) region and 100 autosomal ancestry informative markers. Nasa and Pijao had a predominant Native American ancestry at the autosomal (92%), maternal (97%) and paternal (70%) level. The admixed groups had a predominant Native American mtDNA ancestry (90%), a substantial frequency of European NRY haplotypes (72%) and similar autosomal contributions from Europeans (51%) and Amerindians (45%). Pijao and nearby Ortega were indistinguishable at the mtDNA and autosomal level, suggesting a genetic continuity between them. Comparisons with multiple Native American populations throughout the Americas revealed that Pijao, had close similarities with Carib-speakers from distant parts of the continent, suggesting an ancient correlation between language and genes. In summary, our study aimed to understand Hispanic patterns of migration, settlement and admixture, supporting an extensive contribution of local Amerindian women to the gene pool of admixed groups and consistent with previous reports of European-male driven admixture in Colombia.
AB - Andean populations have variable degrees of Native American and European ancestry, representing an opportunity to study admixture dynamics in the populations from Latin America (also known as Hispanics). We characterized the genetic structure of two indigenous (Nasa and Pijao) and three admixed (Ibagué, Ortega and Planadas) groups from Tolima, in the Colombian Andes. DNA samples from 348 individuals were genotyped for six mitochondrial DNA (mtDNA), seven non-recombining Y-chromosome (NRY) region and 100 autosomal ancestry informative markers. Nasa and Pijao had a predominant Native American ancestry at the autosomal (92%), maternal (97%) and paternal (70%) level. The admixed groups had a predominant Native American mtDNA ancestry (90%), a substantial frequency of European NRY haplotypes (72%) and similar autosomal contributions from Europeans (51%) and Amerindians (45%). Pijao and nearby Ortega were indistinguishable at the mtDNA and autosomal level, suggesting a genetic continuity between them. Comparisons with multiple Native American populations throughout the Americas revealed that Pijao, had close similarities with Carib-speakers from distant parts of the continent, suggesting an ancient correlation between language and genes. In summary, our study aimed to understand Hispanic patterns of migration, settlement and admixture, supporting an extensive contribution of local Amerindian women to the gene pool of admixed groups and consistent with previous reports of European-male driven admixture in Colombia.
KW - Admixture
KW - Colombia
KW - Genetic structure
KW - Mitochondrial DNA
KW - Y-Chromosome
UR - http://www.scopus.com/inward/record.url?scp=85048405862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048405862&partnerID=8YFLogxK
U2 - 10.1016/j.fsigen.2018.06.006
DO - 10.1016/j.fsigen.2018.06.006
M3 - Article
C2 - 29909140
AN - SCOPUS:85048405862
JO - Forensic Science International: Genetics
JF - Forensic Science International: Genetics
SN - 1872-4973
ER -