National cancer clinical trials: Children have equal access; adolescents do not

W. Archie Bleyer, Heriberto Tejeda, Sharon B. Murphy, Leslie L. Robison, Julie A. Ross, Bradley H Pollock, Richard K. Severson, Otis W. Brawley, Malcolm A. Smith, Richard S. Ungerleider

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Purpose. To determine whether adolescents with cancer, who in comparison to younger patients have a higher cancer incidence and lower mortality reduction, have equal access to national cancer clinical trials. Methods. The ethnic/racial distribution of 29,859 subjects < 20 years of age entered onto National Cancer Institute-sponsored clinical trials between January 1, 1991, and June 30, 1994, was compared with the expected distribution of patients of the same age in the United States. Results. The Children's Cancer Group and Pediatric Oncology Group had 29,134 (97.6%) of the total study entries among < 20-year-old subjects during the 3.5 years of surveillance. The adult cooperative groups accounted for < 3% of the clinical trials entries in the 15-19-year age range. When analyzed nationally by region, the underrepresentation of the older adolescent subjects was universal. From other analyses, the two pediatric cooperative groups were estimated to have registered > 94% of the children < 15 years of age who were expected to have been diagnosed to have cancer, but only 21% of the cancer patients in the 1519-year age group. Conclusions. The national pediatric cancer cooperative groups allow the majority of American children < 15 years of age and their families equal opportunity to access clinical cancer trials, regardless of race or ethnic- ity. Among patients 15-19 years of age, however, > 75% are not being enrolled by any cooperative group sponsored by the National Cancer Institute. Thus, older adolescents are disadvantaged with respect to access to the national clinical trials, regardless of their race or ethnicity.

Original languageEnglish (US)
Pages (from-to)366-373
Number of pages8
JournalJournal of Adolescent Health
Volume21
Issue number6
DOIs
StatePublished - Dec 1997
Externally publishedYes

Fingerprint

Clinical Trials
Neoplasms
National Cancer Institute (U.S.)
Vulnerable Populations
Mortality
Incidence

Keywords

  • Adolescents
  • Cancer
  • Children's Cancer Group
  • National cancer trials
  • Pediatric Oncology Group

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Bleyer, W. A., Tejeda, H., Murphy, S. B., Robison, L. L., Ross, J. A., Pollock, B. H., ... Ungerleider, R. S. (1997). National cancer clinical trials: Children have equal access; adolescents do not. Journal of Adolescent Health, 21(6), 366-373. https://doi.org/10.1016/S1054-139X(97)00110-9

National cancer clinical trials : Children have equal access; adolescents do not. / Bleyer, W. Archie; Tejeda, Heriberto; Murphy, Sharon B.; Robison, Leslie L.; Ross, Julie A.; Pollock, Bradley H; Severson, Richard K.; Brawley, Otis W.; Smith, Malcolm A.; Ungerleider, Richard S.

In: Journal of Adolescent Health, Vol. 21, No. 6, 12.1997, p. 366-373.

Research output: Contribution to journalArticle

Bleyer, WA, Tejeda, H, Murphy, SB, Robison, LL, Ross, JA, Pollock, BH, Severson, RK, Brawley, OW, Smith, MA & Ungerleider, RS 1997, 'National cancer clinical trials: Children have equal access; adolescents do not', Journal of Adolescent Health, vol. 21, no. 6, pp. 366-373. https://doi.org/10.1016/S1054-139X(97)00110-9
Bleyer, W. Archie ; Tejeda, Heriberto ; Murphy, Sharon B. ; Robison, Leslie L. ; Ross, Julie A. ; Pollock, Bradley H ; Severson, Richard K. ; Brawley, Otis W. ; Smith, Malcolm A. ; Ungerleider, Richard S. / National cancer clinical trials : Children have equal access; adolescents do not. In: Journal of Adolescent Health. 1997 ; Vol. 21, No. 6. pp. 366-373.
@article{5aab51b6e94f4c4485775c02307d60cf,
title = "National cancer clinical trials: Children have equal access; adolescents do not",
abstract = "Purpose. To determine whether adolescents with cancer, who in comparison to younger patients have a higher cancer incidence and lower mortality reduction, have equal access to national cancer clinical trials. Methods. The ethnic/racial distribution of 29,859 subjects < 20 years of age entered onto National Cancer Institute-sponsored clinical trials between January 1, 1991, and June 30, 1994, was compared with the expected distribution of patients of the same age in the United States. Results. The Children's Cancer Group and Pediatric Oncology Group had 29,134 (97.6{\%}) of the total study entries among < 20-year-old subjects during the 3.5 years of surveillance. The adult cooperative groups accounted for < 3{\%} of the clinical trials entries in the 15-19-year age range. When analyzed nationally by region, the underrepresentation of the older adolescent subjects was universal. From other analyses, the two pediatric cooperative groups were estimated to have registered > 94{\%} of the children < 15 years of age who were expected to have been diagnosed to have cancer, but only 21{\%} of the cancer patients in the 1519-year age group. Conclusions. The national pediatric cancer cooperative groups allow the majority of American children < 15 years of age and their families equal opportunity to access clinical cancer trials, regardless of race or ethnic- ity. Among patients 15-19 years of age, however, > 75{\%} are not being enrolled by any cooperative group sponsored by the National Cancer Institute. Thus, older adolescents are disadvantaged with respect to access to the national clinical trials, regardless of their race or ethnicity.",
keywords = "Adolescents, Cancer, Children's Cancer Group, National cancer trials, Pediatric Oncology Group",
author = "Bleyer, {W. Archie} and Heriberto Tejeda and Murphy, {Sharon B.} and Robison, {Leslie L.} and Ross, {Julie A.} and Pollock, {Bradley H} and Severson, {Richard K.} and Brawley, {Otis W.} and Smith, {Malcolm A.} and Ungerleider, {Richard S.}",
year = "1997",
month = "12",
doi = "10.1016/S1054-139X(97)00110-9",
language = "English (US)",
volume = "21",
pages = "366--373",
journal = "Journal of Adolescent Health",
issn = "1054-139X",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - National cancer clinical trials

T2 - Children have equal access; adolescents do not

AU - Bleyer, W. Archie

AU - Tejeda, Heriberto

AU - Murphy, Sharon B.

AU - Robison, Leslie L.

AU - Ross, Julie A.

AU - Pollock, Bradley H

AU - Severson, Richard K.

AU - Brawley, Otis W.

AU - Smith, Malcolm A.

AU - Ungerleider, Richard S.

PY - 1997/12

Y1 - 1997/12

N2 - Purpose. To determine whether adolescents with cancer, who in comparison to younger patients have a higher cancer incidence and lower mortality reduction, have equal access to national cancer clinical trials. Methods. The ethnic/racial distribution of 29,859 subjects < 20 years of age entered onto National Cancer Institute-sponsored clinical trials between January 1, 1991, and June 30, 1994, was compared with the expected distribution of patients of the same age in the United States. Results. The Children's Cancer Group and Pediatric Oncology Group had 29,134 (97.6%) of the total study entries among < 20-year-old subjects during the 3.5 years of surveillance. The adult cooperative groups accounted for < 3% of the clinical trials entries in the 15-19-year age range. When analyzed nationally by region, the underrepresentation of the older adolescent subjects was universal. From other analyses, the two pediatric cooperative groups were estimated to have registered > 94% of the children < 15 years of age who were expected to have been diagnosed to have cancer, but only 21% of the cancer patients in the 1519-year age group. Conclusions. The national pediatric cancer cooperative groups allow the majority of American children < 15 years of age and their families equal opportunity to access clinical cancer trials, regardless of race or ethnic- ity. Among patients 15-19 years of age, however, > 75% are not being enrolled by any cooperative group sponsored by the National Cancer Institute. Thus, older adolescents are disadvantaged with respect to access to the national clinical trials, regardless of their race or ethnicity.

AB - Purpose. To determine whether adolescents with cancer, who in comparison to younger patients have a higher cancer incidence and lower mortality reduction, have equal access to national cancer clinical trials. Methods. The ethnic/racial distribution of 29,859 subjects < 20 years of age entered onto National Cancer Institute-sponsored clinical trials between January 1, 1991, and June 30, 1994, was compared with the expected distribution of patients of the same age in the United States. Results. The Children's Cancer Group and Pediatric Oncology Group had 29,134 (97.6%) of the total study entries among < 20-year-old subjects during the 3.5 years of surveillance. The adult cooperative groups accounted for < 3% of the clinical trials entries in the 15-19-year age range. When analyzed nationally by region, the underrepresentation of the older adolescent subjects was universal. From other analyses, the two pediatric cooperative groups were estimated to have registered > 94% of the children < 15 years of age who were expected to have been diagnosed to have cancer, but only 21% of the cancer patients in the 1519-year age group. Conclusions. The national pediatric cancer cooperative groups allow the majority of American children < 15 years of age and their families equal opportunity to access clinical cancer trials, regardless of race or ethnic- ity. Among patients 15-19 years of age, however, > 75% are not being enrolled by any cooperative group sponsored by the National Cancer Institute. Thus, older adolescents are disadvantaged with respect to access to the national clinical trials, regardless of their race or ethnicity.

KW - Adolescents

KW - Cancer

KW - Children's Cancer Group

KW - National cancer trials

KW - Pediatric Oncology Group

UR - http://www.scopus.com/inward/record.url?scp=0030734508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030734508&partnerID=8YFLogxK

U2 - 10.1016/S1054-139X(97)00110-9

DO - 10.1016/S1054-139X(97)00110-9

M3 - Article

C2 - 9401854

AN - SCOPUS:0030734508

VL - 21

SP - 366

EP - 373

JO - Journal of Adolescent Health

JF - Journal of Adolescent Health

SN - 1054-139X

IS - 6

ER -