Na+/H+ exchange inhibition (NHEi) attenuates myocardial dysfunction of short-term hibernation in swine

J. D. Symons, L. Martin, Saul Schaefer

Research output: Contribution to journalArticle

Abstract

Regional dysfunction in hibernating myocardium may result from repetitive ischemic episodes causing intracellular Na+ and Ca2+ overload. We hypothesized that NHEi attenuates dysfunction of short-term hibernation in response to repeated cycles of ischemia (I) and reperfusion (R). Six pigs completed 25 cycles of I (2-min) and R (8-min) of the LCx in the absence (CON) and presence of NHEi (HOE 642, 3 mg/kg bolus; 0.08 mg/kg/min infusion, i.a.). A time/vehicle (VEH) protocol did not include I/R. Mean arterial pressure (MAP) and myocardial function (i.e. LCx and LAD regions, sonomicrometry) were measured before I/R, and prior to occlusions 5, 10, 15, 20. and 25. No differences were observed in MAP or LAD function. LCx blood flow (microspheres) was similar among animals following each protocol. LCx function is expressed as a percent of pre-occlusion function <100%±SE). *p<0.05 vs 100%; † vs HOE and VEH. Pre-occlusion# 5 10 15 20 25 CON 80±9* 66±7*† 65±6*† 55±6*† 54±5*† HOE 642 89±4 10±5 80±6* 81±8 72±5* VEH 97±3 96±3 98±5 97±4 99±5 These data indicate that NHEi attenuates regional dysfunction of short-term hibernation in swine.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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