Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

Michael J. Shattock, Michela Ottolia, Donald M Bers, Mordecai P. Blaustein, Andrii Boguslavskyi, Julie B C Bossuyt, John H B Bridge, Ye Chen-Izu, Colleen E Clancy, Andrew Edwards, Joshua Goldhaber, Jack Kaplan, Jerry B. Lingrel, Davor Pavlovic, Kenneth Philipson, Karin R. Sipido, Zi Jian Xie

Research output: Contribution to journalArticle

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Abstract

This paper is the third in a series of reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on cardiac Na+/Ca2+ exchange (NCX) and Na+/K+-ATPase (NKA). While the relevance of Ca2+ homeostasis in cardiac function has been extensively investigated, the role of Na+ regulation in shaping heart function is often overlooked. Small changes in the cytoplasmic Na+ content have multiple effects on the heart by influencing intracellular Ca2+ and pH levels thereby modulating heart contractility. Therefore it is essential for heart cells to maintain Na+ homeostasis. Among the proteins that accomplish this task are the Na+/Ca2+ exchanger (NCX) and the Na+/K+ pump (NKA). By transporting three Na+ ions into the cytoplasm in exchange for one Ca2+ moved out, NCX is one of the main Na+ influx mechanisms in cardiomyocytes. Acting in the opposite direction, NKA moves Na+ ions from the cytoplasm to the extracellular space against their gradient by utilizing the energy released from ATP hydrolysis. A fine balance between these two processes controls the net amount of intracellular Na+ and aberrations in either of these two systems can have a large impact on cardiac contractility. Due to the relevant role of these two proteins in Na+ homeostasis, the emphasis of this review is on recent developments regarding the cardiac Na+/Ca2+ exchanger (NCX1) and Na+/K+ pump and the controversies that still persist in the field.

Original languageEnglish (US)
Pages (from-to)1361-1382
Number of pages22
JournalJournal of Physiology
Volume593
Issue number6
DOIs
StatePublished - Mar 15 2015

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Homeostasis
Cytoplasm
Ions
Myocardial Contraction
Excitation Contraction Coupling
Extracellular Space
Systems Analysis
Cardiac Myocytes
Cardiac Arrhythmias
Proteins
Hydrolysis
Adenosine Triphosphate
Sodium
sodium-translocating ATPase
Direction compound

ASJC Scopus subject areas

  • Physiology

Cite this

Shattock, M. J., Ottolia, M., Bers, D. M., Blaustein, M. P., Boguslavskyi, A., Bossuyt, J. B. C., ... Xie, Z. J. (2015). Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. Journal of Physiology, 593(6), 1361-1382. https://doi.org/10.1113/jphysiol.2014.282319

Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. / Shattock, Michael J.; Ottolia, Michela; Bers, Donald M; Blaustein, Mordecai P.; Boguslavskyi, Andrii; Bossuyt, Julie B C; Bridge, John H B; Chen-Izu, Ye; Clancy, Colleen E; Edwards, Andrew; Goldhaber, Joshua; Kaplan, Jack; Lingrel, Jerry B.; Pavlovic, Davor; Philipson, Kenneth; Sipido, Karin R.; Xie, Zi Jian.

In: Journal of Physiology, Vol. 593, No. 6, 15.03.2015, p. 1361-1382.

Research output: Contribution to journalArticle

Shattock, MJ, Ottolia, M, Bers, DM, Blaustein, MP, Boguslavskyi, A, Bossuyt, JBC, Bridge, JHB, Chen-Izu, Y, Clancy, CE, Edwards, A, Goldhaber, J, Kaplan, J, Lingrel, JB, Pavlovic, D, Philipson, K, Sipido, KR & Xie, ZJ 2015, 'Na+/Ca2+ exchange and Na+/K+-ATPase in the heart', Journal of Physiology, vol. 593, no. 6, pp. 1361-1382. https://doi.org/10.1113/jphysiol.2014.282319
Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt JBC et al. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. Journal of Physiology. 2015 Mar 15;593(6):1361-1382. https://doi.org/10.1113/jphysiol.2014.282319
Shattock, Michael J. ; Ottolia, Michela ; Bers, Donald M ; Blaustein, Mordecai P. ; Boguslavskyi, Andrii ; Bossuyt, Julie B C ; Bridge, John H B ; Chen-Izu, Ye ; Clancy, Colleen E ; Edwards, Andrew ; Goldhaber, Joshua ; Kaplan, Jack ; Lingrel, Jerry B. ; Pavlovic, Davor ; Philipson, Kenneth ; Sipido, Karin R. ; Xie, Zi Jian. / Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. In: Journal of Physiology. 2015 ; Vol. 593, No. 6. pp. 1361-1382.
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