Na+ channel function, regulation, structure, trafficking and sequestration

Ye Chen-Izu, Robin M. Shaw, Geoffrey S. Pitt, Vladimir Yarov-Yarovoy, Jon T. Sack, Hugues Abriel, Richard W. Aldrich, Luiz Belardinelli, Mark B. Cannell, William A. Catterall, Walter J. Chazin, Nipavan Chiamvimonvat, Isabelle Deschenes, Eleonora Grandi, Thomas J. Hund, Leighton T. Izu, Lars S. Maier, Victor A. Maltsev, Celine Marionneau, Peter J. MohlerSridharan Rajamani, Randall L. Rasmusson, Eric A. Sobie, Colleen E. Clancy, Donald M. Bers

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na+ channel function and regulation, Na+ channel structure and function, and Na+ channel trafficking, sequestration and complexing.

Original languageEnglish (US)
Pages (from-to)1347-1360
Number of pages14
JournalJournal of Physiology
Issue number6
StatePublished - Mar 15 2015

ASJC Scopus subject areas

  • Physiology


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