Nanotechnology in bladder cancer: Current state of development and clinical practice

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Nanotechnology is being developed for the diagnosis and treatment of both nonmyoinvasive bladder cancer (NMIBC) and invasive bladder cancer. The diagnostic applications of nanotechnology in NMIBC mainly focus on tumor identification during endoscopy to increase complete resection of bladder cancer while nanotechnology to capture malignant cells or their components continues to be developed. The therapeutic applications of nanotechnology in NMIBC are to reformulate biological and cytotoxic agents for intravesical instillation, combine both diagnostic and therapeutic application in one nanoformulation. In invasive and advanced bladder cancer, magnetic resonance imaging with supraparamagnetic iron oxide nanoparticles can improve the sensitivity and specificity in detecting small metastasis to lymph nodes. Nanoformulation of cytotoxic agents can potentially decrease the toxicity while increasing efficacy.

Original languageEnglish (US)
Pages (from-to)1189-1201
Number of pages13
JournalNanomedicine
Volume10
Issue number7
DOIs
StatePublished - Apr 1 2015

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Keywords

  • bladder cancer
  • nanoparticle
  • photodynamic diagnosis
  • photodynamic therapy

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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