Nanostructures of designed geometry and functionality enable regulation of cellular signaling processes

Jie Ren Li, Lifang Shi, Zhao Deng, Su Hao Lo, Gang-yu Liu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Extracellular matrices (ECM) triggered cellular signaling processes often begin with the clustering of the cellular receptors such as integrin and FcεRI. The sizes of these initial protein complexes or clusters are tens to 100 nm in dimension; therefore, engineered nanostructures could provide effective mimics of ECM for investigation and control of the initial and downstream specific signaling processes. This current topic discusses recent advances in nanotechnology in the context of design and production of matching chemical functionality and geometry for control of specific cellular signaling processes. Two investigations are reported to demonstrate this concept: (a) how the presentation of antigen at the nanometer scale would influence the aggregation of FcεRI, which would impact the formation of activation complexes, leading to the rearrangement of actin in cytoskeleton and degranulation or activation of mast cells; (b) how the engineered nanostructure could guide the initial integrin clustering, which would impact the formation of focal adhesion and downstream cell signaling cascades, leading to polarization, migration, and morphological changes. Complementary to engineered ECMs using synthetic ligands or peptides, or topographic control at the micrometer scale, nanostructures of designed geometry and chemical functionality provide new and effective biochemical cues for regulation of cellular signaling processes and downstream behaviors.

Original languageEnglish (US)
Pages (from-to)5876-5893
Number of pages18
JournalBiochemistry
Volume51
Issue number30
DOIs
StatePublished - Jul 31 2012

Fingerprint

Cell signaling
Nanostructures
Integrins
Extracellular Matrix
Cluster Analysis
Geometry
Nanotechnology
Focal Adhesions
Chemical activation
Antigen Presentation
Actin Cytoskeleton
Military electronic countermeasures
Mast Cells
Cues
Ligands
Actins
Peptides
Adhesion
Agglomeration
Polarization

ASJC Scopus subject areas

  • Biochemistry

Cite this

Nanostructures of designed geometry and functionality enable regulation of cellular signaling processes. / Li, Jie Ren; Shi, Lifang; Deng, Zhao; Lo, Su Hao; Liu, Gang-yu.

In: Biochemistry, Vol. 51, No. 30, 31.07.2012, p. 5876-5893.

Research output: Contribution to journalArticle

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