Nanosecond electroperturbation - Mammalian cell sensitivity and bacterial spore resistance

P. Thomas Vernier, Mya Mya S Thu, Laura Marcu, Cheryl M. Craft, Martin A. Gundersen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ultra-short, high-field electric pulses induce apoptosis in Jurkat T lymphoblasts but have little effect on rat glioma C6 cells even at much higher doses. Germination of Bacillus atrophaeus spores is unaffected even by exposure to millions of nanosecond, megavolt-per-meter pulses. Despite the many fundamental similarities among biological systems at the cellular level, and the well-defined physical and electrical parameters of nanoelectropulse delivery systems, a wide variety of responses to stimuli in this new bioelectromagnetic regime must be anticipated. Future studies can utilize these differences to uncover the underlying mechanisms and to exploit the relative resistances and sensitivities among cell and tissue types for the expansion of fundamental knowledge of cell biology and for practical applications in therapeutics and bioengineering.

Original languageEnglish (US)
Pages (from-to)1620-1625
Number of pages6
JournalIEEE Transactions on Plasma Science
Volume32
Issue number4 II
DOIs
StatePublished - Aug 2004

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spores
bioengineering
germination
electric pulses
Bacillus
sensitivity
apoptosis
cells
stimuli
rats
delivery
dosage
expansion
pulses

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Condensed Matter Physics

Cite this

Nanosecond electroperturbation - Mammalian cell sensitivity and bacterial spore resistance. / Vernier, P. Thomas; Thu, Mya Mya S; Marcu, Laura; Craft, Cheryl M.; Gundersen, Martin A.

In: IEEE Transactions on Plasma Science, Vol. 32, No. 4 II, 08.2004, p. 1620-1625.

Research output: Contribution to journalArticle

Vernier, P. Thomas ; Thu, Mya Mya S ; Marcu, Laura ; Craft, Cheryl M. ; Gundersen, Martin A. / Nanosecond electroperturbation - Mammalian cell sensitivity and bacterial spore resistance. In: IEEE Transactions on Plasma Science. 2004 ; Vol. 32, No. 4 II. pp. 1620-1625.
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